A Study of the Biocompatibility of Carbon Nanotube-Based Nanocomposite Structures Implanted into Muscle Tissue

Gerasimenko, Alexander Yu.; Semak, Anna Eduardovna; Cherepanova, N. G.; Komarchev, A. S.; Sokolova, D. K.; Boyarkin, V. S.; Pyanov, Ivan V.; Ичкитидзе, Л. П.

doi:10.1007/s10527-019-09917-w

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…In another study, carried out on mature Moscow breed roosters by implanting 0.5 mL of protein-carbon nanotube dispersion intramuscularly to the lateral shin. After 90 days of implantation, the reduction in composite volume and a greater number of connective tissue interlayers at the implantation site were observed, implying excellent tissue regeneration with mild inflammatory action of the avian immune system [ 148 ]. Compatibility studies prioritize diminishing after-effects of nanotubes on the host in which they are being injected.…”

Section: Computational Study Of Biocompatibility Of Cntsmentioning

confidence: 99%

Carbon nanotubes in biomedical applications: current status, promises, and challenges

et al. 2022

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In the past decade, there has been phenomenal progress in the field of nanomaterials, especially in the area of carbon nanotubes (CNTs). In this review, we have elucidated a contemporary synopsis of properties, synthesis, functionalization, toxicity, and several potential biomedical applications of CNTs. Researchers have reported remarkable mechanical, electronic, and physical properties of CNTs which makes their applications so versatile. Functionalization of CNTs has been valuable in modifying their properties, expanding their applications, and reducing their toxicity. In recent years, the use of CNTs in biomedical applications has grown exponentially as they are utilized in the field of drug delivery, tissue engineering, biosensors, bioimaging, and cancer treatment. CNTs can increase the lifespan of drugs in humans and facilitate their delivery directly to the targeted cells; they are also highly efficient biocompatible biosensors and bioimaging agents. CNTs have also shown great results in detecting the SARS COVID-19 virus and in the field of cancer treatment and tissue engineering which is substantially required looking at the present conditions. The concerns about CNTs include cytotoxicity faced in in vivo biomedical applications and its high manufacturing cost are discussed in the review. Supplementary Information The online version contains supplementary material available at 10.1007/s42823-022-00364-4.

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Section: Computational Study Of Biocompatibility Of Cntsmentioning

confidence: 99%

Carbon nanotubes in biomedical applications: current status, promises, and challenges

et al. 2022

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“…They have sparked a multitude of uses in materials engineering since they were discovered in 1991 (Iijima, 2002). There are many different applications of CNT, including in electrochemical biosensors (Wang, 2005), drug delivery (Ilbasmiş-Tamer et al, 2010;Ménard-Moyon et al, 2010) pharmaceutical production (Rode et al, 2018), cancer research (Sonmez et al, 2016), tissue engineering (Alshehri et al, 2016;Gerasimenko et al, 2019), and treatments for the brain and nervous system (Parpura, 2008). CNT are particularly valuable for their electrical, chemical, and mechanical properties (Guignier & Bueno, 2019).…”

Section: Introductionmentioning

confidence: 99%

Developing a Novel Growth Method for Carbon-Infiltrated Carbon Nanotubes on Ti6Al4V

Arias¹

2023

Curiosity: Interdisciplinary Journal of Research and Innovation

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Carbon-infiltrated carbon nanotubes (CICNT) are cylindrical rolls of pure carbon atoms with a honeycomb molecular structure. They have specific applications in medical implants due to their biofilm resistance properties. CICNT can be grown on a variety of material substrates such as silicon, stainless steel, and pure titanium. Different substrates require different CICNT growth processes. This study developed a growth method for CICNT on Ti6Al4V, a titanium alloy commonly used as a medical implant material due to its strong mechanical properties and excellent biocompatibility. However, due to the presence of vanadium in the alloy, it is difficult to use it as a substrate for CICNT growth. To solve this problem, this study used an indirect growth method, which placed a barrier layer of alumina (Al2O3) between the Ti6Al4V and an iron growth catalyst layer. A control group was also created without an alumina barrier layer. This study additionally investigated the differences between two deposition methods: electron-beam physical vapor deposition (PVD) and atomic layer deposition (ALD). After CICNT growth, the samples showed that the deposition of the barrier layer allowed the growth of CICNT on Ti6Al4V. Using a scanning electron microscope (SEM), the results also showed that at the levels of alumina studied, the deposition method did not make a difference to CICNT coverage of the Ti6Al4V. These results illustrate the fact that Ti6Al4V can be used as a substrate for CICNT if a barrier layer is used.

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A Study of the Biocompatibility of Carbon Nanotube-Based Nanocomposite Structures Implanted into Muscle Tissue

Cited by 2 publications

References 3 publications

Carbon nanotubes in biomedical applications: current status, promises, and challenges

Carbon nanotubes in biomedical applications: current status, promises, and challenges

Developing a Novel Growth Method for Carbon-Infiltrated Carbon Nanotubes on Ti6Al4V

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