A Study of the Interaction of Polycyclic Derivatives of Azaquinolizinium Salts with DNA

Ibuprofen causes photocleavage through ROS generation and intercalates with DNA: a combined biophysical and molecular docking approach

“…However, if these drugs are merely bound to the phosphate backbone or the grooves, the deactivation by fluorescence emission is favoured leading to a significant increase in the fluorescence emission. 38 In the case of ibuprofen-DNA interaction we have observed the significant quenching with increasing concentration of DNA, suggesting that the binding mode should be intercalative.…”

Intercalation of Organic Dye Molecules into Double‐stranded DNA. Part 2: The Annelated Quinolizinium Ion as a Structural Motif in DNA Intercalators†

“…The replacement of a methylene group next to the quaternary nitrogen atom of quinolizinium derivatives with another nitrogen atom gives azaquinolizinium derivatives, which were also shown to bind to DNA (58–61). Thus, in detailed studies, the indolo‐annelated azaquinolizinium cations 13a–f were shown to intercalate into DNA with binding constants of K ∼ 10 5 M −1 .…”

“…In another recent study, the interaction of acenaphtho‐ and phenanthreno‐annelated azaquinoliziniumderivatives 18 and 19 with DNA was investigated by spectrometric titrations, viscosimetry and equilibrium dialysis studies (60). In representative experiments, the association with DNA was detected by a hypsochromic effect and a redshift of the UV band (Δλ∼ 10 nm) upon addition of the nucleic acid.…”