A study of the properties and efficacy of microparticles based on P(3HB) and P(3HB/3HV) loaded with herbicides

Abstract

The wide use of pesticides in agriculture has caused uncontrolled distribution of these chemicals in the environment, calling for the development and investigation of new environmentally friendly formulations, which would reduce human impact on nature. In the present study, the metribuzin (MET), tribenuron-methyl (TBM), and fenoxaprop-P-ethyl (FPE) herbicides were encapsulated in microparticles of degradable microbial polymerspolyhydroxyalkanoates (PHAs)of two typespoly-3-hydroxybutyrate [P(3HB)] and poly(3-hydroxybutyrate-co-3-hydroxyvalerate [P(3HB/3HV)]. The use of P (3HB) resulted in higher yields of microparticles (63% to 79%) and larger sizes of the particles, whose average diameter was 0.60 ± 0.06-0.75 ± 0.11 μm,

A new series of acylhydrazones derived from metribuzin with modulated herbicidal activity

“…This result could be attributed to the lack of aqueous solubility shown by this aromatic acylhydrazone, which could hinder its translocation inside the weed. A related study dealing with the bioactivity of different herbicide microcapsules, including metribuzin, indicated that herbicidal activity increases with the herbicide solubility [ 56 ]. However, the application of A24 formulations (aliphatic acylhydrazone 24 ) at both doses produced significant decreases in rapeseed biomass compared to the control treatment ( Fig.…”

Recent Biotechnological Applications of Polyhydroxyalkanoates (PHA) in the Biomedical Sector—A Review

“…An application similar to drug delivery was reported by R. Vijayamma et al [84], where a herbicide delivery system composed of P(3HB) and P(3HB/3HV) was tested. Metribuzin, a herbicide derived from 1,2,4-triazine, demonstrated the best release results with an index of 44-48%, and in the tests carried out during the growth of the plant, Elsholtzia ciliata microparticles loaded with metribuzin and tribenuron-methyl demonstrated the best result.…”

Functionalization of Polyhydroxyalkanoates (PHA)-Based Bioplastic with Phloretin for Active Food Packaging: Characterization of Its Mechanical, Antioxidant, and Antimicrobial Activities

“…The formulation of a plethora of PHA-based materials, i.e., copolymers, physical and/or meltreactive blending with tailored polymers, and the addition of organic and inorganic fillers and plasticizers, has led to the improvement of mechanical features, wide processability windows, and enhanced stability and permeability performances [2]. So far, owing to its special polymer features, PHA with diverse structures and properties has been exploited in several application fields, i.e., as bioplastics for food packaging [3], in tissue engineering for biomedical implants and drug delivery carriers [5], and in the agriculture sector for the controlled delivery of herbicides [6].…”