2024
DOI: 10.3389/fntpr.2024.1372623
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A study of the protease inhibitory activity component of SARS-CoV-2 3CL in Bletilla striata

Yuyu Yang,
Fei Zhang,
Shihan Liu
et al.

Abstract: The protease Mpro (referred to as 3CLpro or 3CL protease) is a cysteine protease that is highly conserved in coronavirus and is indispensable for viral replication. Because there is no homologous protein for MPro in the human body, SARS-CoV-2 3CL protease is an ideal target against coronavirus. Bletilla striata (Reich. Bf.) is a well-known form of Traditional Chinese Medicine and can exert many pharmacological effects, including hemostasis, anti-microbial and anti-virus activities. Our preliminary screening sh… Show more

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