A Study on Adverse Drug Reactions in Patients on Antiretroviral Therapy in a Tertiary Care Hospital at Jaipur, Rajasthan

Abstract

Background: The present study was conducted to know the status of ADRs caused due to the first line ART in the ART center of SMS Hospital Jaipur, Rajasthan. This study would be beneficial to the HIV infected patients, with the ultimate goal of improving the tolerability and effectiveness of HIV treatment by promoting the early recognition of potentially serious adverse effects.
 Methods: Hospital based Prospective, Observational study conducted after approval by research review board and ethics committee SMS Medical College Jaipur (Rajasthan). WHO definition of ADR was used (any response to a medicine which is noxious and unintended and which occurs at doses normally used in man). The detail of ADRs collected including suspected drug involved, treatment given for ADRs and outcome.
 Results: Majority of ADRs were related to central and peripheral nervous system related 55 (47%) followed by gastro intestinal 28 (23.9%), dermatological 15 (12.8%), musculoskeletal 9 (7.7%) and metabolic 5 (4.3%).
 Conclusion: Majority of ADRs were related to central and peripheral nervous system related followed by gastro intestinal.
 Keywords: ADRs, HIV, WHO.

Impact of antiretroviral therapy on cutaneous adverse drug reactions in adult HIV patients: A study from a tertiary care hospital

“…The study found CADRs in 16.08% of cases, highlighting their common occurrence in HIV treatment. This prevalence rate aligns with the broader range observed in other studies: 31.57% in Akshaya Srikanth's study, 12 12.8% in Gupta and Agarwal study, 13 study. The variation in these rates could be attributed to differences in patient populations, the specific ART regimens used, and the duration of the studies.…”

“…The study's findings on genetic predispositions to these reactions suggest the potential for personalized medicine approaches in HIV treatment. 13…”