A Study on Antioxidants status in Type 2 Diabetes Mellitus Patients

Abstract

Background: Diabetes mellitus is an endocrinal disorder. Over production of reactive oxygen and nitrogen species thought to be involved in the initiation and development of vascular complications in diabetes. Increased levels of MDA, Vitamin E and Ceruloplasmin are the markers for oxidative stress in type 2 diabetes mellitus. The aim of the present study is to study the Antioxidant status in Type 2 Diabetes patients. Materials & Methods:This, case control study was conducted on 40 subjects. Among them 20 were controls, 20 were known Type 2 Diabetes patients. Patients with T2DM with other endocrinal disorders, patients on antioxidants, minerals and multivitamins as supplement form are excluded from the study. A laboratory investigations consisting of glucose, total cholesterol, triglycerides, HDLC, LDLC Vitamin E, MDA and Ceruloplasmin were carried out on fasting blood sample of subjects selected for this study. Results: In the present study, FBS, PPBS, MDA, Ceruloplasmin, total cholesterol and LDLC were significantly increased in T2DM cases and HDLC, Vitamin E was significantly decreased in cases when compared to controls. (p value <0.05). Conclusion:The findings of this study is in accordance to earlier studies, that there is an increased oxidative stress in diabetics compared to controls; and the oxidative stress further increases as diabetes to cardiovascular diseases. This study emphasizes the importance of assessing the antioxidant status in diabetes in addition to the markers of oxidative stress and lipid profile to formulate the specific therapies for early therapeutic intervention and better treatment of diabetes mellitus.