A study on biological rhythms of Himalayan Pashmina goats

Yatoo, Mohd Iqbal; Bhat, Riyaz Ahmad; Muheet,; Parray, Oveas Raffiq; Shabir, Mir; Kubrevi, Syed Shafat; Dar, Rukhsar Ahmad; Angmo, Kunzes; Kanwar, Maheshwar Singh

doi:10.1080/09291016.2019.1571703

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…The most prevalent disease in the newborn stage is diarrhea, which is typically attributed to infectious sources such as bacteria, viruses, and protozoa [36]. Increased newborn diarrhea was linked to wet spring and summer weather as well as underdeveloped immunological function [37]. Neonatal diarrhea mortality rates varied according to management and conditions for preventing epidemics.…”

Section: Discussionmentioning

confidence: 99%

New Insights on Coding Mutations and mRNA Levels of Candidate Genes Associated with Diarrhea Susceptibility in Baladi Goat

Al‐Sharif

Ateya

2023

Agriculture

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The purpose of this investigation was to examine mutations and mRNA levels of potential genes linked to diarrhea susceptibility in order to assess the health status of diarrheic kids of Baladi goats. One hundred female Baladi kids (35 diarrheic and 65 apparently healthy) were used. PCR-DNA sequencing was conducted for TMED1, CALR, FBXW9, HS6ST3, SMURF1, KPNA7, FBXL2, PIN1, S1PR5, ICAM1, EDN1, MAPK11, CSF1R, LRRK1, and CFH markers revealed nucleotide sequence variants in the frequency of distribution of all detected SNPs (p ˂ 0.05) between healthy and affected kids. Chi-square analysis showed a significant difference between resistant and affected animals. Gene expression profile revealed that TMED1, CALR, FBXW9, HS6ST3, SMURF1, KPNA7, FBXL2, PIN1, S1PR5, ICAM1, EDN1, MAPK11, CSF1R and LRRK1 were significantly up-regulated in diarrheic kids than resistant ones. Meanwhile, CFH gene elicited an opposite trend. On the mRNA levels of the examined indicators, there was a substantial interaction between the type of gene and diarrhea resistance/susceptibility. The findings could support the importance of nucleotide variations and the expression pattern of the examined genes as biomarkers for diarrhea resistance/susceptibility and offer a useful management strategy for Baladi goats.

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Section: Discussionmentioning

confidence: 99%

New Insights on Coding Mutations and mRNA Levels of Candidate Genes Associated with Diarrhea Susceptibility in Baladi Goat

Al‐Sharif

Ateya

2023

Agriculture

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Comparative evaluation of different therapeutic protocols for contagious caprine pleuropneumonia in Himalayan Pashmina goats

Yatoo

Parray

Bhat

et al. 2019

Trop Anim Health Prod

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Changes of Intestinal Oxidative Stress, Inflammation, and Gene Expression in Neonatal Diarrhoea Kids

et al. 2021

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Diarrhea and disorders in young goats are serious threats to the animals' health, influencing the profitability of the goat industry. There is a need to better understand the potential biomarkers that can reflect the mortality and morbidity in neonatal diarrhea goats. Ten pairs of twin kid goats from the same does (one healthy and the other diagnosed as diarrhea) with the same age under 14 days after birth were used in this study. Since gastrointestinal infection is probably the first ailment in neonatal goats, we aimed to investigate the changes in oxidative stress, inflammation, and gene expression in the gastrointestinal tract of neonatal diarrhea goats based on an epidemiological perspective. The results showed the activity of glutathione peroxidase (GSH-Px) was less (P < 0.05) in the jejunum in neonatal diarrhea goats compared with control goats. However, the malondialdehyde (MDA) activities in the jejunum and ileum were higher (P < 0.05) in neonatal diarrhea goats. There was no significant difference in the super-oxide dismutase (SOD) and catalase (CAT) activity observed between the two groups (P > 0.05). For the concentrations of intestinal interleukin-2 (IL2) and interleukin-6 (IL6), only the IL-2 in ileum of neonatal diarrhea goats was higher than that from healthy control goats. The transcriptomic analysis of the jejunum showed a total of 364 differential expression genes (DEGs) identified in neonatal diarrhea goats compared with control goats. The Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis of up-regulated DEGs was mainly related to the ECM–receptor interaction and axon guidance, and the down-regulated DEGs mainly related to the Arachidonic acid metabolism, complement and coagulation cascades, and alpha-Linolenic acid metabolism. Real-time PCR results showed that the expression of most toll-like receptor-4-(TLR4) pathway-related genes and intestinal barrier function-related genes were similar in the two groups. These results suggest that neonatal diarrhea goats experienced a higher intestinal oxidative stress compared with control goats. Thus, it is possible that the antioxidant capacity of young ruminants acts as an indicator of health status and the measurements of oxidation stress may be useful as diagnostic biomarkers, reflecting the mortality and morbidity in neonatal diarrhea goats.

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A study on biological rhythms of Himalayan Pashmina goats

Cited by 3 publications

References 28 publications

New Insights on Coding Mutations and mRNA Levels of Candidate Genes Associated with Diarrhea Susceptibility in Baladi Goat

New Insights on Coding Mutations and mRNA Levels of Candidate Genes Associated with Diarrhea Susceptibility in Baladi Goat

Comparative evaluation of different therapeutic protocols for contagious caprine pleuropneumonia in Himalayan Pashmina goats

Changes of Intestinal Oxidative Stress, Inflammation, and Gene Expression in Neonatal Diarrhoea Kids

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