A study on clinico-pathological assessment of response to neoadjuvant chemotherapy in breast carcinoma

Mohapatra, Manisha; Sarma, Yerraguntla Subramanya

doi:10.4103/jcrt.jcrt_295_19

J Can Res Ther

2020

DOI: 10.4103/jcrt.jcrt_295_19

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A study on clinico-pathological assessment of response to neoadjuvant chemotherapy in breast carcinoma

Manisha Mohapatra¹,

Yerraguntla Subramanya Sarma²

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Cited by 3 publications

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“…NAC has the ability to downsize the tumor, lower the clinical stage, improve the probability of breast preservation, and reduce the extent of axillary surgery. 3 However, some studies have reported that approximately 30-50% of patients have no response to NAC. 4,5 The early identification of patients who can truly benefit from preoperative NAC for individualized treatment is vital to the prognosis and survival of patients.…”

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“…The main treatment principle for BC is surgery‐centered comprehensive therapy, including in combination with systemic adjuvant therapy and/or neoadjuvant chemotherapy (NAC). NAC has the ability to downsize the tumor, lower the clinical stage, improve the probability of breast preservation, and reduce the extent of axillary surgery 3 . However, some studies have reported that approximately 30–50% of patients have no response to NAC 4,5 .…”

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Evaluating Tumor‐Infiltrating Lymphocytes in Breast Cancer

Jia

Zhu

et al. 2022

J of Ultrasound Medicine

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Objectives Tumor‐infiltrating lymphocytes (TILs) have emerged as an efficient biomarker predicting treatment response and prognosis of breast cancer (BC). This study aimed to evaluate the association between conventional ultrasound and contrast‐enhanced ultrasound (CEUS) imaging features with TIL levels in invasive BC patients. Methods We retrospectively included 267 women with invasive BC who had undergone conventional ultrasound and CEUS. Patients were divided into low (≤10%) and high (>10%) TIL groups. Conventional ultrasound and CEUS features were analyzed by two sonographers. The associations between the TIL levels and imaging features were evaluated. Results Of the 267 patients, 122 with high TILs and 145 with low TIL levels. High TIL tumors were more likely to have a circumscribed margin, oval or round shape, and enhanced posterior echoes on ultrasonography (p < 0.05). In contrast, low TIL tumors were more likely to have an irregular shape, un‐circumscribed, indistinct and spiculated margin (p < 0.05). In CEUS, high TIL tumors showed a more regular shape, clearer margin, more homogeneous enhancement and higher peak intensity (PI) value (p < 0.05). Logistic analysis indicated that shape, posterior features, PI, and enhanced homogeneity were independent predictors for high TIL tumors. The model combined the four independent predictors have a moderate performance in predicting high TIL tumors with AUC 0.79, sensitivity 0.72, and specificity 0.78. Conclusions Conventional ultrasound and CEUS features were associated with TIL levels in invasive BC. Consequently, the results suggested that preoperative conventional ultrasound and CEUS may be a useful noninvasive imaging biomarker for individualized treatment decisions.

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confidence: 99%

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confidence: 99%

Evaluating Tumor‐Infiltrating Lymphocytes in Breast Cancer

Jia

Zhu

et al. 2022

J of Ultrasound Medicine

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Assessment of the cardiorespiratory fitness and the quality of life of patients with breast cancer undergoing chemotherapy: a prospective study

et al. 2023

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Clinicopathological and prognostic characteristic features of triple negative and nontriple negative breast cancer at a tertiary care hospital

Mohapatra

2023

Journal of Cancer Research and Therapeutics

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Context: Carcinoma breast is a complex disease having diverse clinical, histopathological, and immunohistochemical features. Basing on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2) status, these tumors are divided into triple-negative breast cancers (TNBC) where tumor cells are negative for all three receptors and nontriple negative breast cancer (non-TNBC) where tumor cells are positive for one or two or all. The clinicopathological and characteristic prognostic features are highlighted here. Aim: The aim of this study is to evaluate the clinicopathological and prognostic features of TNBC and non-TNBC cases diagnosed in our hospital setting. Settings and Design: Single institution, retrospective study conducted over 7 and half years. Subjects and Methods: Histopathologically confirmed breast cancer cases with ER, PR, and HER2 receptor assessment were categorized into TNBC and non-TNBC. Detailed study on clinicopathological and prognostic features including pathological prognostic stage as per 8th AJCC was done in cases who underwent modified radical mastectomy. Statistical Analysis Used: Data were analyzed in percentage and presented in tables and charts. Results: The present study included 794 cases consisting of 253, 31.9% TNBC and 541, 68.1% non-TNBC cases. The mean age of TNBC and non-TNBC cases was 50.4 years and 51.7 years, respectively. Coagulative necrosis, lymphovascular invasion, lymph nodal metastasis, higher histopathological tumor grade, and NPI were observed in higher percentage of TNBC cases, i.e., 19 (10.9%), 21 (11.6%), 105 (57.7%), 127 (69.8%), and 149 (81.9%) cases, respectively, than non-TNBC seen in 18 (6.6%), 24 (8.8%), 135 (49.6%), 165 (60.7%), and 194 (71.3%) cases, respectively. Further, 25 (13.7%) TNBC and 1 (0.4%) non-TNBC case were upstaged, whereas 130 (47.8%) non-TNBC and 2 (1.1%) TNBC cases were downstaged by the pathological prognostic stage. Conclusions: TNBC is more aggressive having a poor prognosis than non-TNBC.

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A study on clinico-pathological assessment of response to neoadjuvant chemotherapy in breast carcinoma

Cited by 3 publications

References 0 publications

Evaluating Tumor‐Infiltrating Lymphocytes in Breast Cancer

Evaluating Tumor‐Infiltrating Lymphocytes in Breast Cancer

Assessment of the cardiorespiratory fitness and the quality of life of patients with breast cancer undergoing chemotherapy: a prospective study

Clinicopathological and prognostic characteristic features of triple negative and nontriple negative breast cancer at a tertiary care hospital

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