A Study on Effect of Vitamin E as an Adjuvant to Metronidazole in Experimental Model of peritonitis

Shrivastava, Deepak; Gharde, Pankaj; Sharma, Dhananjaya; Jain, R.K.; Sharma, Deepti Bala; Saxena, Arjun

doi:10.7439/ijbar.v4i12.577

Cited by 1 publication

(1 citation statement)

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“…Intraperitoneal cephazolin sodium in a dose of 50 mg/kg was given to groups 3 and 4 one hour after the injection of E. coli suspension. There are many clinical studies made by antibiotics or antibiotics and other drugs combinations to limit peritonitis such as antibiotic + vitamin E [ 12 ], antibiotics + normobaric oxygen therapy [ 13 ], and antibiotics + oxygen-free radicals scavengers [ 14 ]. It can be seen that etanercept has been used for suppression of inflammation in autoimmune diseases such as rheumatoid arthritis [ 15 ], ankylosing spondylitis [ 16 ], psoriatic arthritis [ 17 ], and psoriasis vulgaris [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Intraperitoneal Etanercept on Oxidative Stress in Rats with Peritonitis

Yildirim

Cellad

Kara

et al. 2016

Oxidative Medicine and Cellular Longevity

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Our aim was to evaluate effect of etanercept on oxidative stress parameters in rats with experimental peritonitis and investigate the availability of etanercept usage in the treatment of peritonitis in the future. Twenty-eight rats were divided into four groups as control (group 1), peritonitis (group 2), peritonitis + cefazolin sodium (group 3), and peritonitis + cefazolin sodium + etanercept (group 4). Peritoneal tissue and blood samples were taken from all of the rats for histopathological and biochemical examination. The oxidative stress parameters were examined in blood and tissue samples. It was observed that rats with peritonitis benefit from cefazolin sodium treatment. Evaluating the effectiveness of etanercept was our main objective for this study. In this perspective, we compared group 3 and group 4 and found statistically significant decreases in oxidative parameters and statistically significant increases in antioxidants in serum and tissue samples in group 4. It is observed that there was a significant contribution of etanercept on biochemical and also histopathological results. As a result, the TNF-α inhibitor, etanercept, in addition to antibiotics given in the early treatment of peritonitis results in more significant improvement of histopathological and oxidative parameters as compared to antibiotics alone.

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Section: Discussionmentioning

confidence: 99%