A Study on effectiveness of Preoperative versus Postoperative Misoprostol Administration in cesarean section to evaluate Primary Postpartum Hemorrhage

Abstract

Background: Caesarean section (CS) is a frequently performed as a surgical operation, accounting for approximately one-third of all such procedures. Cesarean section rates continue to grow year after year around the world. A Caesarean section can cause a number of maternal and foetal lethal complications, the most serious of which is postpartum haemorrhage (PPH) Aim of the work: To examine the safety and efficacy of preoperative vs postoperative misoprostol for reducing postpartum bleeding after cesarean surgery. Patients and methods: This prospective single-blinded study included 150 women administrated for cesarean section. They had been randomly assigned to either the preoperative misoprostol or postoperative misoprostol, . The study had been conducted at Obstetrics and Gynecology department, Al Hussein University Hospital.Results: Postoperative Hematocrit level (24 hours post-cesarean section) in the Preoperative Misoprostol Group was ranged between 32.20 and 35.00 with a mean ± S.D. 33.55±0.701 while in the Postoperative Misoprostol Group ranged between 28.0 and 31.0 with a mean ± S.D. 29.29±0.782. There were statistically significant variations in the results between the two groups where P<0.001. Conclusion:Preoperative misoprostol can be used to avoid excessive intraoperative and immediate postoperative blood loss.. Pregnancy procedures with a high potential for harm should have access to it. It is safer and more effective to provide misoprostol in CS before to incision than after administration to prevent loss of blood during cesarean section and to function as a prophylactic uterotonic to prevent postpartum hemorrhage after cesarean sections.