A study on feto-maternal outcome of intra hepatic cholestasis of pregnancy

Mitra, Barnali; Maji, Debkalyan; Borse, Dhananjay

doi:10.18203/2320-1770.ijrcog20196041

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…16 A study conducted in India by Binay et al reported that first symptoms of cholestasis appeared in 34-36 weeks of pregnancy in 66% cases and in 32-34 weeks in 15%, before 32 weeks I n 14% while at 37 weeks in 5% cases. 17 Another similar study by Eshadi et al reported vaginal delivery in 56.7% and cesarean section in 43.3% cases. 18 Aftab et al found perinatal outcomes in their study as 29% cases had meconium stained liquor, abnormal CTG detected in 17%, 18% had intrauterine retarded growth, 26% were premature births while 3% had intrauterine fetal death.…”

Section: Discussionmentioning

confidence: 80%

Frequency of Fetomaternal Complications Due to Intrahepatic Cholestasis of Pregnancy

Rehman,

Gulbaz,

Zafar

et al. 2023

PJMHS

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Objective: To study frequency of complications in fetus and mothers developed due to intrahepatic cholestasis during pregnancy. Materials and methods: This is a cross sectional study conducted in the department of gynecology and obstetrics Rai medical College Sargodha. Study was commenced in July 2022 and completed in December 2022. Study sample was calculated using WHO sample size calculator. Pregnant ladies presenting with intrahepatic cholestasis of pregnancy having age 16-40 years were included in this study. Patients with multiple pregnancies, or having carcinoma of liver, presence of chronic liver disease or history of alcohol addiction were excluded from the study. Proper follow ups were done in all pregnant women till the delivery having gestational age ≤ 41 weeks. All necessary data regarding feto-maternal outcomes was documented on a proforma like mode of delivery, APGAR Score, postpartum hemorrhage, low birth weight, meconium stained liquor, premature birth or intrauterine fetal death. Results: This study was conducted on 130 cases with intrahepatic cholestasis, cesarean section was done in 55(42.3%) cases, post-partum hemorrhage reported in 09(6.9%), APGAR score was <7 at five minutes in 11(8.5%), preterm birth happened in 29(22.3%), low birth weight reported in 12(9.2%), intrauterine death of the fetus reported in 08(6.1%) and meconium stained liquor was noted in 41(31.5%) cases. Mean age of the mothers was 24±3.7 years. Practical Implication: In our community we have to consider this health issue seriously if we want to reduce mortality due to ICP and its associated complications in our community. Conclusion: This study concluded that intrahepatic cholestasis of pregnancy is related to poor fetomaternal outcomes that can be prevented by some serious recommendations for such high risk pregnancies. It will reduce fetomaternal morbidity and mortality rate in our setups. Keywords: Intrahepatic cholestasis, Intrauterine death, Pregnancy, Fetomaternal complications, Postpartum hemorrhage,

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Section: Discussionmentioning

confidence: 80%

Frequency of Fetomaternal Complications Due to Intrahepatic Cholestasis of Pregnancy

Rehman,

Gulbaz,

Zafar

et al. 2023

PJMHS

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“…Mitra B et al 2020 10 Gupta S et al 2022 19 Arthuis C et al 2022 22 Alsulyman et al 1996 25 Jhirwal M et al 2022 13 Our study MSL 29.93% Hablani K et al 2022 16 Gupta S et al 2022 19 Alsulyman et al 1996 25 Mitra…”

Section: Fetomaternal Outcomementioning

confidence: 80%

The prevalence of pruritus gravidarum and its relation with intrahepatic cholestasis of pregnancy

Choudhary

Kaur

et al. 2023

Int J Res Med Sci

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Background: Pruritus is a common complaint amongst pregnant woman, affecting 20% of them. This can be physiological or due to some specific dermatological conditions. Among them Intrahepatic cholestasis of pregnancy is most common cause and is characterized by pruritus with derranged liver enzymes and raised serum bile acid levels in the absence of any other liver pathology. It is associated with increased fetomaternal morbidity. Methods: This was a prospective study, conducted at Bebe Nanki Mother and Child Care Centre, Government Medical College, Amritsar in the Department of Obstetrics and Gynaecology with collaboration of Dermatology Department, from March 2021 to Aug 2022. After taking ethical approval, informed consent, detailed history, clinical and biochemical assessment was done and fetomaternal outcome was recorded. Results: Prevalance of pruritus was 20.8% amongst pregnant women, of which 24% patients were diagnosed having intrahepatic cholestasis of pregnancy (ICP) and 76% were labelled as NON ICP patients. Among NON ICP patients prevalence of pruritic urticarial papules and plaques of pregnancy was 32.10%. Majority intrahepatic cholestasis of pregnancy patients had moderately affected quality of life. Majority of pruritic patients had normal bilirubin levels and all intrahepatic cholestasis of pregnancy patients had raised serum Alanine transaminase, Aspartate transaminase, bile acids values. Meconium stained liquor, preterm delivery, Low birth weight, cesarean rates, NICU admissions rates were higher in intrahepatic cholestasis of pregnancy patients. Conclusions: Pruritus in pregnancy is a common condition. Dermatological opinion along with liver function tests should be done to know about the cause and severity of pruritus. Intrahepatic cholestasis of pregnancy (ICP) affects perinatal outcomes. So patients should be closely monitored to improve the fetomaternal outcome.

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“…7 Fetal complications of IHCP likely to raised fetal serum bile acids taurocholic and taurodeoxycholic acid. 8 Alkaline phosphate (ALP) is raised normally in pregnancy and is considered abnormally high if there is at least 3 fold increase over the normotensive pregnant normal value (upper limit of normal range). All participants were closely monitored on a weekly basis by a clinical staff in an outpatient setting.…”

Section: Exclusion Criteriamentioning

confidence: 99%

Evaluation of bile acid and deranged liver function test in obstetrics cholestasis in pregnancy in fetal and perinatal outcome

Mani¹,

Sachdeva²,

Chaudhary³

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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Background: Pregnancy-related intrahepatic cholestasis is most prevalent hepatic disorder intense pruritus that affects the entire body including palm and sole. It is typically detected during second or third trimester. Pruritus frequently exacerbates at night, marked on the palms and soles of the feet and hands. Aim of this study was to evaluate bile acid and deranged liver function test in obstetrics cholestasis in pregnancy and to determine maternal fetal and outcomes. Methods: This prospective case series study was conducted in the Department of Obstetrics and Gynaecology, Muzaffarnagar Medical College. The present study was conducted in 50 women, who were selected from outpatient department of antenatal care from tertiary care, taken written permission before study. The medical records of all women with obstetrics cholestasis who delivered between December 2021and August 2022. Results: Subjects with IHCP has mean age of 30.11±5.03 year, found SGOT 40% in 100-200 and SGPT 44 % I (0-100) range and total bilirubin levels is 33 % in IHCP patients. In study found that LSCS due to 24% in fetal distress, 36% in MSL, 16% in IUGR, 14% preterm. Participants have 22% birth weight <2.5kg and 39 (78%) are under >2.5kg babies in IHCP patients and 24 % were underwent fetal distress and 24 % preterm delivery and 6 % got IUD . and no stillborn and 12% meconium. Conclusions: It causes maternal pruritus with impaired LFT and raised serum bile acids. Maternal morbidity is increased in terms of increased LSCS rates and discomfort due to pruritus.

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A study on feto-maternal outcome of intra hepatic cholestasis of pregnancy

Cited by 6 publications

References 9 publications

Frequency of Fetomaternal Complications Due to Intrahepatic Cholestasis of Pregnancy

Frequency of Fetomaternal Complications Due to Intrahepatic Cholestasis of Pregnancy

The prevalence of pruritus gravidarum and its relation with intrahepatic cholestasis of pregnancy

Evaluation of bile acid and deranged liver function test in obstetrics cholestasis in pregnancy in fetal and perinatal outcome

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