A Study on Haematological Parameters in Febrile Seizures

Abstract

Febrile seizures are the most common neurologic disorder in the pediatric age group, affecting 2–5% of children between 6 months and 5 years of age in the United States and Western Europe with a peak incidence between 12 and 18 months. Although febrile seizure is seen in all ethnic groups, it is more frequently seen in the Asian population (5–10% of Indian children and 6–9% of Japanese children). Systemic inflammatory response has been implicated as a contributor to the onset of febrile seizure [1]. It is studied that IL-B, IL-6, TNF-ALPHA can play an important role in generation of febrileseizure. Although they are the useful biomarkers, its availability in day to day practice is very limited. So there is a need for low cost and widely used inflammatory response markers like NLR, MPV, PLT, and RDW as independent predictors of febrile seizure and to compare different Hematological parameters in febrile seizure in patients with an unclear seizure history. The 5 novel indices of inflammatory response: i. Neutrophil Lymphocyte Ratio ii. Mean Platelet Volume iii. Platelet Count Ratio iv. Red cell Distribution Width v. Serum Ferritin The study is carried out for the assessment of other hematological parameters in febrile seizures like HB, RBC, PCV, RDW, Platelets, MPV and PCR. Also to compare the variation of hematological parameters in simple and complex febrile seizures based on the laboratory parameters which are otherwise classified clinically.