A Study on Insulin Resistance and Its Association With Obesity in Polycystic Ovary Syndrome

Abstract

Objective: - The aim of this study was to compare the level of Insulin Resistance in PCOS women with healthy women and analyze its association with obesity. Methodology:-The study was conducted on 150 PCOS women and 150 age-matched healthy controls. BMI was calculated from height (m) and weight (kg) in all the subjects. Serum fasting glucose and insulin were estimated by photometric and immunoassay methods. Insulin Resistance was calculated using HOMAindex. Difference in all the parameters between PCOS women and healthy women were analyzed by t-test and correlation between two parameters were accessed with Pearson's correlation test. Results:- PCOS women had signicantly high (p < 0.0001) 2 levels of BMI (27.12 ± 3.51 v/s 23.34 ± 2.12 kg/m ), fasting glucose (91.28 ± 11.88 v/s 84.81 ± 10.68 mg/dl), fasting insulin (23.11 ± 6.25 v/s 10.98 ± 5.11 µIU/ml) and HOMA-IR (5.32 ± 1.93 v/s 2.39 ± 1.40) compared to healthy controls. Asignicant positive correlation (r = 0.784; p< 0.0001) was observed between HOMA-IR values and BMI in PCOS. Conclusion: - Increased level of Insulin Resistance indicates its role in disease progression. Further, the positive correlation of HOMA-IR with BMI explains the development of the disease to be related with obesity