A Study on Oxidative stress and antioxidant status in Diabetic nephropathy

Abstract

Diabetes mellitus is the most common metabolic disorder in the world. The metabolic dysregulation of diabetes mellitus affects multiple organs like Kidneys, nerves, eyes and heart. Worldwide Among all diabetics, 20-40% of the people are suffering from Diabetic Nephropathy. Oxidative stress is increased by hyperglycemia in which Reactive Oxygen Species has been implicated in the pathology of these complications. The aim of our present study is one such attempt to find the role of oxidative stress by estimating the levels of oxidants and anti oxidant levels in diabetic nephropathy in ethnic south Indian population. 30 diagnosed cases of diabetic Nephropathy were taken as cases and 30 age and sex matched Type 2 Diabetes mellitus patients were included as controls in the study. For oxidant levels Malondialdehyde (MDA) was estimated and for anti oxidant levels Super oxide Dismutase (SOD), Glutathione Peroxidase (GPx), Glutathione Reductase (GR) were measured. Statistically significant increase is observed in the levels of Malondialdehyde in cases when compared to controls. There is no statistical significant difference in the levels of Superoxide dismutase and Glutathione peroxidase between cases and controls. Whereas statistical significant difference is observed in the levels of Glutathione reductase in Diabetic Nephropathy cases when compared with controls.