A study on phthalate metabolites, bisphenol A and nonylphenol in the urine of Chinese women with unexplained recurrent spontaneous abortion

Fanli, Peng; Ji, Wenliang; Zhu, Feng; Peng, Danhong; Yang, Miao; Liu, Ran; Pu, Yuepu; Yin, Lu

doi:10.1016/j.envres.2016.04.003

Cited by 72 publications

(32 citation statements)

References 31 publications

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“…According to the results of previous related studies 33–38 , the magnitude of associations and types of phthalate metabolites with pregnancy loss remain inconsistent. We hypothesized that the discrepancy between the present study and the previous studies was attributed partially to the differences in maternal characteristics, study design, sample size and miscarriage type and partially to co-linearity among phthalate metabolites.…”

Section: Discussionmentioning

confidence: 98%

“…We hypothesized that the discrepancy between the present study and the previous studies was attributed partially to the differences in maternal characteristics, study design, sample size and miscarriage type and partially to co-linearity among phthalate metabolites. For instance, previous studies were from three different countries (Denmark, America and China) and both cohort 33–35 and case control study designs 36–38 were employed. All studies had small sample sizes which would create large variations among studies.…”

Section: Discussionmentioning

confidence: 99%

“…37 included 150 women with missed miscarriages and 150 healthy controls; Peng et al . 38 enrolled only a total of 30 cases with unexplained recurrent spontaneous abortion and 30 controls. In addition, these three case-control studies recruited individuals with different miscarriage types.…”

Section: Discussionmentioning

confidence: 99%

“…Peng et al . 38 found that mono- iso -butyl phthalate (MiBP) and MBP concentrations in women with unexplained recurrent spontaneous abortion were remarkably higher than those in control group. Differences in study design, population characteristics, sample size, and miscarriage type are likely to contribute to the conflicting results.…”

Section: Introductionmentioning

confidence: 93%

“…However, another cohort study of 221 American women had opposite findings that mono (2-ethyl-5-hydroxyhexyl) phthalate (MEOHP) and DEHP were related to decreased risk of subclinical embryonic loss, and insignificant relationship between any analyzed compounds and clinical pregnancy loss 35 . In China, all current conclusions on associations between phthalates and miscarriage are solely based on case-control studies 36–38 . A case-control study (132 clinical pregnancy loss cases and 172 healthy controls) revealed that an increased risk of clinical pregnancy loss was associated with monoethyl phthalate (MEP) and mono- n -butyl phthalate (MBP) 36 .…”

Section: Introductionmentioning

confidence: 99%

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Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women

Gao

Zhang

Huang

et al. 2017

Sci Rep

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Limited evidence revealed conflicting results on relationship between phthalate exposure and clinical pregnancy loss (gestational weeks >6). A prospective cohort study in Chinese pregnant women (n = 3220) was conducted to investigate the association between urinary phthalate metabolites and clinical pregnancy loss (gestational weeks 6 to 27; n = 109). Morning urine samples during gestational weeks 5 to 14 (mean 10.42) were collected to measure monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP). The concentrations of low- and high-molecular weight phthalate metabolites (ΣLMWP <250 Da and ΣHMWP >250 Da) were calculated. Adjusted logistic regression models showed increased risks of clinical pregnancy loss in women with higher creatinine- normalized concentrations of MEP, MBP, MEOHP, MEHHP, ΣLMWP and ΣHMWP. Stratified analysis by gestational weeks (10 weeks) of miscarriage indicated positive associations of MEP, MEOHP, MEHHP and ΣHMWP with embryonic loss (during gestational weeks 6 to 10). The only association of foetal loss (during gestational weeks 11 to 27) was observed with MEHHP. Our findings suggested that Chinese women who were exposed to phthalates during early pregnancy had an increased risk of clinical pregnancy loss, especially embryonic loss.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women

Gao

Zhang

Huang

et al. 2017

Sci Rep

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An Ultrasensitive Electrochemical Immunosensor for Nonylphenol Leachate from Instant Noodle Containers in Southeast Asia

Hao

et al. 2019

Chemistry A European J

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Nonylphenols (NPNs) are persistent endocrine disruptors and their release into the environment is causing increasing concern about their impact on human health. Herein, an ultrasensitive electrochemical immunosensor was developed for the detection of NPNs in the leachates from 61 instant noodle containers (INCs) from 8 countries across Southeast Asia. Gold nanoclusters (AuNCs) were self‐assembled with reduced graphene oxide (rGO; polyethylenimine–rGO) and used to modify a glassy carbon electrode (GCE), which showed excellent electrical conductivity. An anti‐NPN antibody was then immobilized on the AuNCs and, if it specifically bound NPN, the reduction in conductivity of the GCE was remarkable. The designed immunosensor has a low detection limit (5.25 ng L−1) and high sensitivity for NPNs in the leachates of INCs. Remarkably, the leaching of estrogen‐like compounds from different plastics of INCs and the correlation between NPN content and total estrogenic activity were thoroughly investigated. High temperatures caused polyethylene and polystyrene INCs to release more estrogen‐like compounds than that of polypropylene INCs; this increased release of NPNs was associated with higher estrogen activity in living cells. These data fill the gap in human and environmental exposure to estrogen‐like compounds through INCs.

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Phthalates

Wen¹,

Huang²,

Tsai³

et al. 2019

Health Impacts of Developmental Exposure to Environmental Chemicals

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A study on phthalate metabolites, bisphenol A and nonylphenol in the urine of Chinese women with unexplained recurrent spontaneous abortion

Cited by 72 publications

References 31 publications

Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women

Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women

An Ultrasensitive Electrochemical Immunosensor for Nonylphenol Leachate from Instant Noodle Containers in Southeast Asia

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