A study on the association of serum 1,5‐anhydroglucitol levels and the hyperglycaemic excursions as measured by continuous glucose monitoring system among people with type 2 diabetes in China

Wang, Y; Zhang, Y L; Wang, Y P; Lei, Cheng-Hao; Sun, Zilin

doi:10.1002/dmrr.2278

Cited by 19 publications

(17 citation statements)

References 23 publications

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“…Previous studies have shown that glycemic distributions vary among different races. For example, in the European population, diabetes patients mainly present with increased FPG 7 , 8 , whereas in the Asian population, diabetes patients exhibit postprandial hyperglycemia 18 , which was also observed in the current study. It was reported that 1,5-AG is clearly superior to HbA 1c in the accessment of postprandial glucose levels, especially for patients with HbA 1c < 8% 17 , 18 .…”

Section: Discussionsupporting

confidence: 83%

Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the efficiency of diabetes screening in a Chinese population

Ying

et al. 2017

Sci Rep

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Serum 1,5-anhydroglucitol (1,5-AG) levels can not only accurately reflect the mean blood glucose over the previous 1–2 weeks in diabetic patients but also offers the advantage of representing postprandial glucose. To evaluate the clinical significance of 1,5-AG in diabetes detection, especially when used in combination with fasting plasma glucose (FPG), a total of 3098 participants at high risk for diabetes (1467 men, 1631 women) were enrolled. A total of 1471 (47.5%) participants were diagnosed with diabetes, and the mean 1,5-AG level in the diabetic group was significantly lower than that in non-diabetic group [12.5 (7.8–17.5) μg/mL vs. 20.5 (15.3–26.4) μg/mL, P < 0.001]. The optimal cut-off point was 15.9 μg/mL, for which the sensitivity, specificity, and area under the curve (AUC) were 69.2%, 72.3%, and 0.781, respectively. For the combination of FPG and 1,5-AG, the sensitivity, specificity, and AUC improved to 82.5%, 83.5%, and 0.912, respectively. This method helped 75.8% of the participants avoid an oral glucose tolerance test (OGTT), reducing the need to carry out the OGTT by 43.9% compared to the use of the FPG criterion only. In conclusion, the addition of FPG to serum 1,5-AG improves the efficiency of diabetes screening in the Chinese population.

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Section: Discussionsupporting

confidence: 83%

Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the efficiency of diabetes screening in a Chinese population

Ying

et al. 2017

Sci Rep

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“…1,5-AG in males was much higher than in females in our study, which was consistent with some other previous studies. 23,24,28,29 The positive correlation between UA and 1,5-AG found in this study may partly explain this situation as males had much higher UA than females. Previous studies 30 suggested that this may be attributed to the physical differences in the renal excretion rate between genders.…”

Section: Discussionmentioning

confidence: 53%

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Chen

Wang

Tan

et al. 2020

Journal of Diabetes

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Background: Serum 1,5-anhydroglucitol (1,5-AG) is a new glycemic marker which can reflect glucose fluctuation over 3 to 7 days and is now increasingly used to monitor glucose control and to screen for diabetes. However, 1,5-AG has not been widely used in China due to lack of epidemiological support. Our study aims to establish the reference intervals for a population with normal glucose tolerance in Jiangsu Province and to explore the determinants of these intervals. Method:The study enrolled 646 healthy adults aged 20 to 70 years in Jiangsu Province in 2018 after oral glucose tolerance test. 1,5-AG, fasting and 2-hour glucose, UA, liver enzyme, serum lipid, creatinine, and glycosylated hemoglobin were measured. We calculated reference intervals using the parametric method and examined the relationship between 1,5-AG and influence factors.Results: The average age of the participants was 50.5 ± 9.0 years, and 69.5% of them were females. The reference intervals were 15.8 to 52.6 μg/mL for males and 14.3 to 48.0 μg/mL for females. Among females, the reference intervals were 13.9 to 45.3 and 14.6 to 49.6 μg/mL for menopausal and postmenopausal females, respectively. Males showed higher 1,5-AG concentrations than females, and postmenopausal females had higher 1,5-AG than menopausal females. There was a positive correlation between uric acid and 1,5-AG in both genders. Positive correlation between 1,5-AG and age was only observed in females. Conclusion:We established reference intervals for 1,5-AG in Jiangsu Province, and the level of 1,5-AG is affected by sex, uric acid, and age. Highlights• Males, menopausal females, and postmenopausal females had corresponding reference intervals for 1,5-anhydroglucitol (1,5-AG). • Levels of serum uric acid and age should be taken into consideration when interpreting 1,5-AG.

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“…Mealtime faster aspart and IAsp were effective in controlling PPG (assessed by both the meal test and SMPG) and improved levels of 1,5-AG, a marker for postprandial hyperglycemia (22,23). In studies of basal-bolus therapy in type 2 diabetes, changes in HbA 1c are often small and nonsignificant (;0.09%) (21).…”

Section: Discussionmentioning

confidence: 99%

Faster Aspart Versus Insulin Aspart as Part of a Basal-Bolus Regimen in Inadequately Controlled Type 2 Diabetes: The onset 2 Trial

et al. 2017

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OBJECTIVEThis multicenter, double-blind, treat-to-target, phase 3 trial evaluated the efficacy and safety of fast-acting insulin aspart (faster aspart) versus insulin aspart (IAsp) in adults with type 2 diabetes receiving basal insulin and oral antidiabetic agents. RESEARCH DESIGN AND METHODSThe primary end point was HbA 1c change from baseline after 26 weeks' treatment. After an 8-week run-in to optimize basal insulin, subjects were randomized (1:1) to mealtime faster aspart (n = 345) or IAsp (n = 344), titrated using a simple daily patientdriven algorithm, plus insulin glargine U100 and metformin. RESULTS HbA CONCLUSIONSFaster aspart and IAsp were confirmed noninferior in a basal-bolus regimen regarding change from baseline in HbA 1c . Faster aspart improved 1-h PPG with no differences in 224-h PPG versus IAsp. Overall hypoglycemia rates were similar except for an increase in 022-h postmeal hypoglycemia with faster aspart.Basal insulins are one of the recommended steps in type 2 diabetes treatment intensification when oral antidiabetic drugs (OADs) no longer provide sufficient glycemic control (1). As b-cell function decreases further, maintaining target HbA 1c levels becomes challenging, even when target fasting plasma glucose (FPG) levels have been achieved (2), and further therapeutic intensification may be required (3). The aim of

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A study on the association of serum 1,5‐anhydroglucitol levels and the hyperglycaemic excursions as measured by continuous glucose monitoring system among people with type 2 diabetes in China

Cited by 19 publications

References 23 publications

Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the efficiency of diabetes screening in a Chinese population

Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the efficiency of diabetes screening in a Chinese population

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Faster Aspart Versus Insulin Aspart as Part of a Basal-Bolus Regimen in Inadequately Controlled Type 2 Diabetes: The onset 2 Trial

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