A study on the association of genes for pro-inflammatory cytokines and depression

Лежейко, Т. В.; Andryushchenko, A. V.; Коровайцева, Г. И.; Kondratiev, N. V.; Gabaeva, M. V.; Krikova, E. V.; Голимбет, В. Е.

doi:10.17116/jnevro20181183189-93

Cited by 5 publications

(9 citation statements)

References 28 publications

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“…Serum CRP levels were related to decreased motivation and psychomotor retardation [82], as well as to symptoms of anxiety in psychiatric patients [83,84]. Even some polymorphisms of pro-inflammatory cytokine genes, including IL-1β, TNF, and CRP, appeared to be linked with depression and treatment response [85][86][87][88].…”

Section: Peripheral Inflammation and Depressionmentioning

confidence: 99%

State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders

Mucci

Marazziti

Vecchia

et al. 2020

Life

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Mounting evidence highlights the involvement of inflammatory/immune systems and their relationships with neurotransmitters and different metabolic processes in mood disorders. Nevertheless, there is a general agreement that available findings are still inconclusive. Therefore, further investigations are required, aimed at deepening the role of possible alterations of biomarkers in the pathophysiology of mood disorders that might lead to more focused and tailored treatments. The present study is a comprehensive review on these topics that seem to represent intriguing avenues for the development of real innovative therapeutic strategies of mood disorders.

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Section: Peripheral Inflammation and Depressionmentioning

confidence: 99%

State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders

Mucci

Marazziti

Vecchia

et al. 2020

Life

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“…The −511C allele in IL1B was associated with higher ILB expression [30] and higher IL-1β levels. The −511C/T polymorphism was associated with a depression [31,34]. The risk variant for depression was the CC genotype (p = 0.001, OR = 1.9 CI 1.3-2.7) [31].…”

Section: Santos Et Al (2016) [50]mentioning

confidence: 94%

“…The −511C/T polymorphism was associated with a depression [31,34]. The risk variant for depression was the CC genotype (p = 0.001, OR = 1.9 CI 1.3-2.7) [31]. There is much research dedicated to studying the contribution of IL1B-511C/T in the pathogenesis of depression disorders.…”

Section: Santos Et Al (2016) [50]mentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder

Mikhalitskaya

Vyalova

Ermakov

et al. 2023

Genes

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Immune gene variants are known to be associated with the risk of psychiatric disorders, their clinical manifestations, and their response to therapy. This narrative review summarizes the current literature over the past decade on the association of polymorphic variants of cytokine genes with risk, severity, and response to treatment for severe mental disorders such as bipolar disorder, depression, and schizophrenia. A search of literature in databases was carried out using keywords related to depressive disorder, bipolar disorder, schizophrenia, inflammation, and cytokines. Gene lists were extracted from publications to identify common genes and pathways for these mental disorders. Associations between polymorphic variants of the IL1B, IL6, and TNFA genes were the most replicated and relevant in depression. Polymorphic variants of the IL1B, IL6, IL6R, IL10, IL17A, and TNFA genes have been associated with schizophrenia. Bipolar disorder has mainly been associated with polymorphic variants of the IL1B gene. Interestingly, the IL6R gene polymorphism (rs2228145) was associated with all three diseases. Some cytokine genes have also been associated with clinical presentation and response to pharmacotherapy. There is also evidence that some specific polymorphic variants may affect the expression of cytokine genes. Thus, the data from this review indicate a link between neuroinflammation and severe mental disorders.

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“…Several genes are associated with anxiety [ 38 ], including the interleukin (IL)-1β gene [ 39 ]. An Italian study reported the role of the IL-1β gene in developing anxiety and the effects of psychobiotics in reducing anxiety symptoms, with 43.24% of anxious subjects being A allele carriers of the IL-1β gene and the rest 11.43% of subjects being anxious non-carriers.…”

Section: Reviewmentioning

confidence: 99%

Gut Biome and Mental Health: Do Probiotics Work?

Madabushi¹,

Khurana²,

Gupta³

et al. 2023

Cureus

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Mental health conditions have been linked closely to an imbalance of microbiota in the gut, leading to disruption of the microbiome (dysbiosis). Several neurotransmitters, such as GABA (gamma-aminobutyric acid), serotonin, and glutamate, are produced in the gut, which are associated with anxiety and depressive symptoms. Mental health and the gut have been linked closely, and many mental illnesses have been associated with gut dysbiosis. Probiotics are marketed to improve gut health, act as mood enhancers, and be effective in reducing stress as unregulated over-the-counter supplements. Given healthcare disparities and patient-doctor gaps across the globe, this review aims to appraise the literature on probiotics for the prevention and treatment of mental disorders. PubMed and Google Scholar databases were searched till March 2023 using the MeSH words “prebiotics,” “probiotics,” “synbiotics,” and “psychobiotics.” Out of 207 studies, 26 studies met the inclusion criteria and were included in the review. Studies suggest probiotics could be an effective and economical adjunct therapy; however, due to weak study design and low power, the results are inconclusive. Their use is not without risks, and healthcare providers need close supervision until more robust longitudinal studies are conducted to appraise their efficacy and safety profiles.

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A study on the association of genes for pro-inflammatory cytokines and depression

Cited by 5 publications

References 28 publications

State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders

State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders

Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder

Gut Biome and Mental Health: Do Probiotics Work?

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