A study on the clinicopathological correlation of psoriasis with extent of expression of Osteopontin in OPD patients

Abstract

Objective: To evaluate the clinico-pathological Correlation of Osteopontin in patients of Psoriasis. Methods: A cross-sectional clinical correlation study was done on 53 clinically diagnosed cases of psoriasis. All clinically diagnosed cases of Psoriasis were included after taking proper consent in a signed proforma. Patients were clinically evaluated and a proper history was taken including patient's age, sex, site, duration, family history, community, Itching, nail involvement, H/O associated endocrine disorder, H/O associated skin disorders. The Psoriasis Area and Severity Index (PASI) score was evaluated on the basis of area coverage and plaque appearance.A detailed study of histopathological features and IHC osteopontin expression was analyzed. Results: About one fourth of patients were 20-30 &>40 years of age (26.4%). More than half of patients were males (69.8%). Lower limb was the most common affected site (75.5%). The duration of disease was 12-24 months in 50.9% patients. Psoriasis vulgaris was the most common clinical diagnosis (26.4%). Induration was among majority of patients (94.3%). PASI score ≥10 was among more than half of patients (60.4%). Parakeratosis and Dermal inflammation were the most common histopathological changes (96.2%). Moderate positivity of Osteopontinin the epidermis which was present among more than half of patients (60.4%) followed by weak (30.2%) and strong positivity (9.4%).In Dermis osteopontin positivity was moderate in (50.9%),followed by weak(39.6%) and strong positivity(9.4%)respectively. Conclusion: Because of varied clinical, histopathological and IHC feature of psoriasis. A definitive diagnosis in doubtful cases can be made by a combination of all the above parameters.