A Study on the Fabrication of an Effective Natural Substance Based on Schisandra chinensis Extracted Fermentation

Nguyên, Chi Thành; Han, Jongman; Tran, Van-Huong; Jeong, Hun; Kim, Eun Sook

doi:10.2147/ccid.s336280

Cited by 1 publication

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References 30 publications

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“…Abnormal and uncontrolled production and distribution of melanin can cause many dermatological disorders. Among melanin-related problems, we can distinguish lentigines, melasma and post-inflammatory hyperpigmentation [39,40]. To obtain new, efficient telomerase inhibitors, different types of compounds from natural sources have been intensively investigated.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of Schisandra chinensis Extracts and Their Applicability in Skin Care Product

et al. 2022

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Plant extracts have been widely used for skin care for many centuries, and nowadays, they are commonly applied for the development and enrichment of new cosmetic preparations. The present study aimed the assessment of the biological activity of aqueous Schisandra chinensis extracts as a potential ingredient of skin care products. The aspects studied involved the ability to neutralize free radicals, impact on viability and metabolism of keratinocytes, as well as tyrosinase inhibitory potential. Our study showed that aqueous S. chinensis extracts have a positive effect on keratinocyte growth and have high antioxidant potential and strong tyrosinase inhibitory activity. UPLC-MS analysis revealed that three groups of phenolic compounds were predominant in the analyzed extract, including lignans, phenolic acids and flavonoids and protocatechiuc and p-coumaryl quinic acids were predominant. Moreover, microwave-assisted extraction, followed by heat reflux extraction, was the most effective for extracting polyphenols. Furthermore, a prototypical natural body washes gel formulation containing the previously prepared extracts was developed. The irritation potential and viscosity were assessed for each of the formulations. The study demonstrated that the addition of these extracts to body wash gel formulations has a positive effect on their quality and may contribute to a decrease in skin irritation. In summary, S. chinensis aqueous extracts can be seen as an innovative ingredient useful in the cosmetic and pharmaceutical industry.

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Section: Discussionmentioning

confidence: 99%