A study on the prevalence of risk factors and presence of diabetic foot ulcers in T2DM patients in K. R. Hospital, Mysuru

Chandrashekar, S; Muralidhar, Suraj

doi:10.18203/2349-2902.isj20173611

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Two studies of the Indonesian population in other regions such as Manado and Denpasar reported that the majority of diabetic patients were ≥50 years (76.3%) and 50-59 years (46.9%), respectively [19], [20]. Other reports from India and a meta-analysis also provide data that diabetic foot was predominantly shown in older patients (aged >50 years) [21], [22], [23], [24]. This difference might due to the high proportion of patients (33.3%) in our study being diagnosed with T2DM when they were <40 years old.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphism FokI and 25-Hydroxy Vitamin D Levels among Indonesian Diabetic Foot Patients

Raflis

Yuwono

Yanwirasti

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Vitamin D and VDRs FokI has been reported to be strongly associated with type 2 diabetes mellitus (T2DM) through controlling inflammation of endothelial cells in diabetic foot cases. AIM: This study aimed to detect Vitamin D receptor FokI polymorphisms and to determine the Vitamin D levels among diabetic foot patients in sunlight-rich areas. MATERIALS AND METHODS: A cross sectional study was conducted among diabetic foot patients who were treated as T2DM, from November 2016 to June 2018 in Padang city, Indonesia. There are an inclusion and exclusion criteria listed below. A questionnaire for symptoms-based screening, ankle brachial index (ABI) examination, fasting glucose, and HbA1c were measured. Electroimmunoassay (ECLIA) was used to determine Vitamin D levels as sufficiency, insufficiency, and deficiency. Polymerase chain reaction assay was addressed for VDR FokI genetic polymorphisms. Data were analyzed to evaluate the differences of explanatory variables (age, gender, duration of T2DM, fasting blood sugar, body mass index [BMI], HbA1c, and Vitamin D levels) across different genotypes of VDR FokI for three groups based on the absent T allele (ff: wild type homozygous, Ff: mutant heterozygous, and FF: mutant homozygous). RESULTS: Among 36 eligible subjects, 52.8% were females, 61.1% were <50 years old, 63.9% had normal BMI, and 86.1% had normal ABI. Vitamin D deficiency, insufficiency, and sufficiency were shown in 19.4%, 33.3%, and 47.2% of the subjects, respectively. The majority of VDR FokI gene polymorphisms were mutant heterozygous Ff (44.4%), wild type homozygous ff (13.9%), and mutant homozygous FF (41.7%). Results of one-way ANOVA showed that there were no differences of BMI, ABI, fasting blood glucose, Vitamin D levels, and Hb1AC status with the VDR FokI gene polymorphisms. Based on Vitamin D levels, most of the Vitamin D deficiency subjects had 31.2% VDR FokI Ff allele, 13.3% had FF allele, and none of them had ff allele. CONCLUSION: This study concluded that most of the individuals with diabetic foot in a sunlight-rich area tended to have mutant VDR FokI polymorphisms and Vitamin D insufficiency.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphism FokI and 25-Hydroxy Vitamin D Levels among Indonesian Diabetic Foot Patients

Raflis

Yuwono

Yanwirasti

et al. 2020

Open Access Maced J Med Sci

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“…In India, 16% to 53% of patients with diabetes mellitus have microvascular complications. 76,77 Comorbidities. Patients with diabetes are particularly susceptible to foot infection primarily because of neuropathy, vascular insufficiency, and diminished neutrophil function.…”

Section: Safety Of Antibiotics: Limitations Of Current Anti-mrsa Agentsmentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus in Diabetic Foot Infection in India: A Growing Menace

Viswanathan

Pendsey²,

Radhakrishnan

et al. 2019

The International Journal of Lower Extremity Wounds

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Diabetic foot infection (DFI) is a serious and common complication of diabetes mellitus. These infections are potentially disastrous and rapidly progress to deeper spaces and tissues. If not treated promptly and appropriately, DFI can be incurable or even lead to septic gangrene, which may require foot amputation. Mostly, these infections are polymicrobial, where Gram-positive pathogens mainly Staphylococcus aureus play a dominant causative role. Methicillin-resistant Staphylococcus aureus (MRSA) is present in 10% to 32% of diabetic infections and is associated with a higher rate of treatment failure, morbidity, and hospitalization cost in patients with DFIs. The increasing resistance of bacteria and the adverse effects pertaining to the safety and tolerability towards currently available anti-MRSA agents have limited the available treatment options for patients with DFI. Infection control, antimicrobial stewardship, and rapid diagnostics based on the microbiological culture and the antimicrobial susceptibility testing results are important components in helping curb this disturbing trend. Emphasis to revisit a vigorous research effort in order to improve the therapeutic options for the increasingly resistant and highly adaptable MRSA is the need of hour. Through this review article, we have made an attempt to explore the ongoing therapeutic trends in the management of DFI and highlighted the challenges in treatment of DFI. We have also given a brief overview of a few novel drugs that are under development to treat MRSA infections.

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Impact of multidisciplinary foot care team on outcome of diabetic foot ulcer in term of lower extremity amputation at a tertiary care unit in Karachi, Pakistan

Riaz

Miyan

Waris

et al. 2019

International Wound Journal

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To compare the outcomes of diabetic foot ulcers (DFU) in terms of healing and lower extremity amputation (LEA) rate before and after training of multidisciplinary foot care team (MDFCT). Subjects were categorised into two groups; Group‐A cases seen between 1997 and 2006 (before upgrading of training and services of MDFCT) and Group‐B cases seen between 2007 and 2016 (after upgrading of training and services of MDFCT). Baseline demographic characteristics, biochemical results, and outcomes of DFU in terms of healing or amputation were analysed by using statistical package social science (SPSS) version 20. Total 7994 DFU cases seen, 888 in group A and 7106 in group B. Mean age of patients was 53.80 ± 10.40 years and mean haemoglobin (HbA1c) was 10.12 ± 2.44. Overall, decreasing trends of amputations were observed from baseline 27.5% to 3.92% during the period of 20 years. In group A, 479 (78.8%) subjects healed completely compared with 3806 (89.1%) in group B. Significant reduction in toe amputations ([13.81%] vs [8.11%]) and below knee amputations [(5.26%) vs (1.82%)] were seen. Similarly, rates of above knee amputation ([1.80%] vs [0.35%] P‐value 0.008) in two groups was also significant. Significant improvement was observed in outcomes of DFU in terms of amputation through multidisciplinary team approach.

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A study on the prevalence of risk factors and presence of diabetic foot ulcers in T2DM patients in K. R. Hospital, Mysuru

Cited by 5 publications

References 11 publications

Vitamin D Receptor Gene Polymorphism FokI and 25-Hydroxy Vitamin D Levels among Indonesian Diabetic Foot Patients

Vitamin D Receptor Gene Polymorphism FokI and 25-Hydroxy Vitamin D Levels among Indonesian Diabetic Foot Patients

Methicillin-Resistant Staphylococcus aureus in Diabetic Foot Infection in India: A Growing Menace

Impact of multidisciplinary foot care team on outcome of diabetic foot ulcer in term of lower extremity amputation at a tertiary care unit in Karachi, Pakistan

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