A study on the safety evaluation of buphrenorphine administered through an autoinjector compared with manual injection using haematological and biochemical variables in rats

Abstract

<jats:p> Buprenorphine drug cartridge was made for autoinjector device for use in emergency and critical situations to reduce the morbidity and mortality. Water-filled cartridges were prepared and buprenorphine was injected aseptically in the cartridge, to make 0.05 and 0.10 mg/mL. Rats were injected intraperitoneally, buprenorphine (0.3 and 0.6 mg/kg), repeatedly with the autoinjector and compared with manual injection (7 days and 14 days) using various haematological and biochemical parameters. No significant change was observed in the body weight, organ to body weight ratio and haematological variables in any of the experimental groups compared with the control group. Except serum urea and aspartate aminotransferase, no significant change was observed in glucose, cholesterol, triglycerides, bilirubin, protein, albumin, creatinine, uric acid, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase. The autoinjectors deliver the drugs with spray effect and force for faster absorption. In the present study, the autoinjector meant for intramuscular injection was injected intraperitoneally in rats, and the drug was delivered with force on the vital organs. No significant difference was observed in the autoinjector group compared to the manual group showing tolerability and safety of the buphrenorphine autoinjector. This study shows that buprenorphine autoinjector can be considered for further research work. </jats:p>

Safety evaluation of antibacterial and analgesic autoinjector devices for rapid administration during emergency situations: a crossover study in rabbits

“…is not feasible. 10 , 13 The developed AID for human has an option to select full or partial drug delivery (2.0 and 1.2 mL, respectively) equivalent to full or partial needle length of injection (25 and 15 mm, respectively). 11 Hence, for i.m.…”

“…injection for the tolerability. 9 , 13 , 17 Hence, the present study was carried out in rabbit model.…”

Autoinjector – A smart device for emergency cum personal therapy

“…Buprenorphine administered through autoinjector was compared with manual injection and found to be safe in rat model ( Sheela et al, 2015 ). The buprenorphine cartridges for analgesic purpose were prepared and safety evaluation and quality control tests were carried out and found to be safe for further research The haematological and biochemical parameters were evaluated after administering buprenorphine for 7 and 14 days and there was no significant difference between the autoinjector and manual injection ( Sheela et al, 2017 ).…”

Autoinjector device for rapid administration of drugs and antidotes in emergency situations and in mass casualty management

“…48 Extensive preclinical studies carried out in animal models showed that an amikacin AID and a buprenorphine AID were tolerated, safe and well suited for mass casualty management. 50 A naloxone AID is very safe and effective for the management of opioid overdose. 51 A combination of buprenorphine and naloxone might be better and could be considered.…”