A Study Regarding the Mechanical Properties of a Hybrid Matrix with Various Volume Proportions of Dammar

Bolcu, Dumitru; Stănescu, Marius Marinel; Ciucă, Ion; Miriţoiu, Cosmin Mihai; Diniţă, Alin; Bolcu, Alexandru

doi:10.37358/mp.20.1.5320

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…The composition of the volatile compounds and residues arising from PU thermal decomposition is influenced by the conditions of synthesis and the nature of the raw materials [68]. However, the safety of PU biomaterials is not a concern due to their high stability up to 300 • C according to the literature [69]. By inspecting the thermogravimetric curves of the current samples, a significant thermal stability was observed up to 200 • C; the investigation of the thermal decomposition above 200 • C is not relevant for materials intended for used in biomedical related applications, but it is worthwhile because of the study of macromolecular chains (hard vs. soft segments) and to predict the half-life of a pharmaceutical formulation [70] or the compatibility between a drug and various excipients [71].…”

Section: Discussionmentioning

confidence: 99%

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Borcan,

Vlase,

Vlase

et al. 2023

JFB

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The delivery of nucleosides represents an interesting research trend in recent years due to their application in various viral infections. The main aims of this study were to develop and to characterize polyurethane particles that are intended to be used for the transport of nucleosides. Three samples have been prepared using aliphatic diisocyanates, a mixture of polyethylene glycol, polycaprolactone, and diols, respectively. The samples were characterized through refractivity measurements, drug loading efficacy, release and penetration rate investigations, FTIR and Raman spectroscopy, thermal analyses, Zetasizer, SEM, HDFa cells viability, and irritation tests on mice skin. The results indicate the obtaining of particles with sizes between 132 and 190 nm, positive Zeta potential values (28.3–31.5 mV), and a refractivity index around 1.60. A good thermal stability was found, and SEM images show a medium tendency to agglomerate. The samples’ color, pH, and electrical conductivity have changed only to a small extent over time, and the evaluations indicate an almost 70% encapsulation efficacy, a prolonged release, and that around 70% of particles have penetrated an artificial membrane in the first 24 h. The synthesized products should be tested in further clinical trials, and the current tests on cell cultures and mice skin revealed no side effects.

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Section: Discussionmentioning

confidence: 99%

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Borcan,

Vlase,

Vlase

et al. 2023

JFB

View full text Add to dashboard Cite

show abstract

“…The composition of the volatile compounds and residues arising PU thermal decomposition is influenced by the conditions of synthesis and the nature of the raw materials [50]. However, the safety of PU biomaterials is not a concern due to their high stability up to 300 °C according to the literature [51].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of 2'-Deoxycytidine-5'-monophosphate sodium salt

Borcan¹,

Vlase²,

Popescu³

et al. 2023

Preprint

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The drug delivery systems receive more and more attention for the control and treatment of many diseases due to their increased number in recent years. The main aims of this study were to develop and to characterize a polyurethane drug delivery system that it is intended to be used for the transmembrane transport of nucleosides. Three different samples have been synthesized based on aliphatic diisocyanates (hexamethylene diisocyanate, isophorone diisocyanate and lysine diisocyanate) as organic phase, respectively a mixture of polyethylene glycol, polycaprolactone diol and low molecular weight diols as aqueous phase. The samples were characterized by pH, refractivity index and solubility measurements, drug loading efficacy and release investigations, thermal behavior, Zetasizer, cells viability and irritation tests on mice skin. The results indicate the obtaining of different populations of neutral acido-basic particles with size between 132 and 190 nm; the Zeta potential values and SEM images show a medium tendency to form clusters, while UV-Vis evaluations indicate an almost 70% encapsulation efficacy, a prolonged release (45% of encapsulated substance is released in the first 5 days) and around 70% of particles have penetrated an artificial membrane in the first 24h. The synthesized products can be tested in further clinical trials, the currently tests on cells culture and mice skin revealing no side effects.

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“…In [4] are studied non-uniformities occurring in composite bars reinforced with fiberglass fabric and a coefficient is introduced in order to assess the non-uniformities in composite bars having two parts, each of it having its own reinforce volume ratio. In [5] are studied non-uniformities occurring in composite bars reinforced with carbon fabric and with combined fabric of carbon and kevlar, respectively.…”

Section: Preliminariesmentioning

confidence: 99%

Structure-Related Non-uniformities in Composite Bars Made of Hybrid Dammar-Based Resin and Reinforced with Natural Fiber Fabrics

Bolcu¹,

Rizescu²,

Dumitru³

2023

Atlantis Highlights in Engineering

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The paper presents the factors characterizing the non-uniformities that might occur during the technological process of making composite materials. These factors were analyzed in cases of two types of composite materials made of hybrid Dammar-base resin and reinforced with hemp and linen fabric, respectively. Multilayer composite-made specimens with one or more interrupted layers of 2 cm or 4 cm were built. In the aftermath of a certain tensile stress applied on each and every composite material specimen, the elasticity factor, the strength factor and the uniformity factor (even factor) were experimentally found out.

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A Study Regarding the Mechanical Properties of a Hybrid Matrix with Various Volume Proportions of Dammar

Cited by 4 publications

References 19 publications

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Synthesis and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of 2'-Deoxycytidine-5'-monophosphate sodium salt

Structure-Related Non-uniformities in Composite Bars Made of Hybrid Dammar-Based Resin and Reinforced with Natural Fiber Fabrics

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