A Successful Live Birth Through In Vitro Fertilization and Embryo Transfer in Stage IVb Endometrial Carcinoma after Conservative Treatment: a Case Report

Abstract

Introduction An increasing number of young patients with early-stage endometrial cancer are opting for fertility-sparing treatment, and they have achieved reassuring rates of complete remission, with some women achieving pregnancy. However, surgical treatment is still recommended for patients with advanced endometrial cancer. We reported a woman with IVb endometrial cancer (EC) who reached complete remission (CR) and gained a live birth successfully with the help of in vitro fertilization and embryo transfer (IVF-ET). Case report A 30-year-old woman found to have stage IVb EC after hysteroscopy, laparoscopy, and pathological examination. After a combination of chemotherapy and progesterone therapy, the woman achieved complete remission. The woman became pregnant with IVF-ET and got a full-term live birth. In addition, there was no recurrence after 19 months of observation. The molecular classification of POLE and the combination of chemotherapy and progesterone therapy may be associated with a good prognosis of this patient. The use of progestin-primed ovarian stimulation (PPOS) and the combination of letrozole and levonorgestrel-releasing intrauterine device (LNG-IUD) during ovulation induction seemed to be safe for the woman Conclusion This is the first report on fertility-sparing treatment and live birth for advanced EC. IVF-ET is feasible for women with EC who preserve reproductive function. The progestin-primed ovarian stimulation combined with levonorgestrel-releasing intrauterine device and letrozole seems to be safe for these women. Patients still need to be closely watched for tumor recurrence.