A Sudanese Maduromycosis

Chalmers, Albert J.; Archibald, R. G.

doi:10.1080/00034983.1916.11684111

Cited by 44 publications

(3 citation statements)

References 2 publications

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“…Later, Pinoy recognized the possibility of classifying the cases of mycetoma by grouping the causative organisms, and the formal classification was put into place by Chalmers and Archibald who divided them into two groups. [ 5 6 ]…”

Section: Introduction and Historical Aspectsmentioning

confidence: 99%

Mycetoma: An update

et al. 2017

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Mycetoma is a localized chronic, suppurative, and deforming granulomatous infection seen in tropical and subtropical areas. It is a disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of localized swelling, underlying sinus tracts, and production of grains or granules. Etiological classification divides it into eumycetoma caused by fungus, and actinomycetoma caused by bacteria. Since the treatment of these two etiologies is entirely different, a definite diagnosis after histopathological and microbiological examination is mandatory, though difficult. Serological test exists but is not so reliable; however, molecular techniques to identify relevant antigens have shown promise. The disease is notoriously difficult to treat. Eumycetoma may be unresponsive to standard antifungal therapy. Actinomycetoma responds to antibiotic therapy, but prolonged treatment is necessary. This review focuses on the etiopathogenesis, clinical features, laboratory diagnosis, and treatment of mycetoma.

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Section: Introduction and Historical Aspectsmentioning

confidence: 99%

Mycetoma: An update

et al. 2017

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“…9 In 1913, Pinoy et al recognized the possibility of classifying mycetomas according to the causative organisms. 10 The formal classification, which is still valid, was put into place by Chalmers and Archibald, who divided them into two groups: 11 group 1, maduramycosis (eumycetoma), caused by true fungi; and group 2, actinomycosis (actinomycetoma), caused by Actinomyces belonging to a higher bacteria class.…”

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confidence: 99%

Treatment of refractory mycetoma by radiotherapy: a case study and review

Gupta

Sharma

Gupta

et al. 2021

Precision Radiation Oncology

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Mycetoma is a localized chronic subcutaneous infection caused by fungi. It is clinically characterized by a triad of tumefaction, sinuses, and discharge containing typical grains. Eumycetoma, a subtype, is characterized by a low cure rate. Long‐term medication and surgical excision are required to treat the infection. Radiotherapy, a less used modality of treatment, may provide a good salvage option for refractory eumycetoma. Herein, we present a case and a review of the literature of refractory eumycetoma of the foot where radiotherapy was used as a salvage treatment. In the present case, a dose of 17.5 Gy in five fractions was delivered, and the response was assessed as per the Response Evaluation Criteria in Solid Tumors 1.1, discharging grains status, and Dermatology Life Quality Index. The literature on the use of radiotherapy for mycetoma was found to be scanty. In the present case with radiotherapy, there was a partial radiological response, resolution of discharging grains, and improvement in the Dermatology Life Quality Index score. However, the benefit was short‐lived, but re‐irradiation and low‐dose radiotherapy resulted in sustained benefits until 15 months of follow up. The antiproliferative and anti‐inflammatory actions of radiotherapy can be exploited in the treatment of rare, medically difficult to treat mycetoma. This case report may serve as a basis for further evaluation.

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“…3 Pinoy classified mycetoma based on causative organisms, and the formal classification was framed by Chalmers and Archibald. 4,5 Mycetomas are caused by various species of fungi and bacteria. They occur as saprophytes in soil or on the plants.…”

Section: Introductionmentioning

confidence: 99%

Clinical study on task specific dystonia among beedi workers

2020

IJN

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Mycetoma is a localized chronic, suppurative granulomatous disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of grains, tumour and tracts. It is commonly seen in tropical and subtropical areas. Based on causative organisms it is classified into eumycetoma caused by fungus, and actinomycetoma caused by bacteria. Color of grains also helps in differentiating the organisms. Black grains are always produced by fungi; pale grains are produced by bacteria and fungus. Diagnosis is based on the classical clinical presentation, histopathology and microbiological examination. Serological tests are not helpful. Molecular techniques to detect antigens are still under study. Eumycetoma is very resistant to treatment. Actinomycetoma responds well to prolonged antibiotic therapy.1,2 We present here in detail a series of five cases of mycetoma diagnosed in our hospital in a span of six months.

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A Sudanese Maduromycosis

Cited by 44 publications

References 2 publications

Mycetoma: An update

Mycetoma: An update

Treatment of refractory mycetoma by radiotherapy: a case study and review

Clinical study on task specific dystonia among beedi workers

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