The Madrid Astronomical Observatory implemented a solar observation program from 1876 to 1986. In addition to sunspots, the observers at this observatory recorded other solar features such as prominences. In this work, we have consulted the documentary sources of the Madrid Astronomical Observatory (the information is not digitally available), digitized the records of the observers on the annual number of prominences, and constructed a homogeneous series of the total and hemispheric annual number of prominences with heights of 25’’ and more for the period 1906 – 1957. To evaluate the quality of the data and assess their potential, we have compared the Madrid prominence series with the number of prominences recorded by the Astronomical Observatory of the University of Coimbra and other time series such as the sunspot number index, solar radio flux at 10.7 cm, and sunspot areas. We have also analyzed the hemispheric prominence numbers and the asymmetry index. We obtained the strongest correlation between Madrid and Coimbra prominence series (r = 0.7), whereas the correlations between Madrid prominence series and the other solar activity time series are similar (r ≈ 0.6). In addition, we found that the correlation coefficient between the Madrid prominence series and the sunspot number is lower than that from Coimbra prominence series and the sunspot number. We suggest that these differences are a consequence of the way prominences were counted in the Madrid Astronomical Observatory.