A supramolecular hydrogel for generation of a benign DNA-hydrogel

Ultra-high stable chitosan functionalized gold nanoparticles (GNPs) of desired biopolymeric corona are synthesized without adding conventional hazardous reducing agents. The inherent unique set of properties like reducing ability, stabilizing effect, and mucoadhesiveness of chitosan is exhibited in the present work. Morphologies and ultra-stability of the synthesized materials are characterized by standard techniques. The mucoadhesiveness of the synthesized materials are well documented through the biological potency of the synthesized GNPs. The prominent bioactivity is evident from the antifilarial activity. The cellular and molecular level studies on the induction of oxidative stress, DNA damage, and undesirable protein expression clearly explain the antifilarial activities. Interestingly, the developed nanoparticle shows no detectable sign of toxicity when evaluated in vitro (rat peritoneal MФ) or in vivo (Wistar rat). Therefore, the synthesized green GNPs appear to be a substantial promise as an efficacious broad-spectrum nanotherapeutic agent with safe outcome for clinical attempt.

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“…Double staining technique AO/EtBr differential double staining was performed following the procedure depicted in our previous studies [11,27].…”

Section: Gold Particle Induced Apoptosis: Determination Of Apoptogenimentioning

confidence: 99%

Chitosan biopolymer functionalized gold nanoparticles with controlled cytotoxicity and improved antifilarial efficacy

Chowdhury

Roy

Mukherjee

et al. 2018

Adv Compos Hybrid Mater

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“…For example, as shown in Figure , the synthesis of AuNPs inside the matrix of Au(III)‐absorbed hydrogel is reported through direct reduction, applied as environmentally friendly and sustainable hybrid for catalytic activities . Similar approach is also presented for the stabilization of photochemically synthesized silver nanoparticles by nontoxic hydrogels composed of positively charged protonated 2ʹ,4ʹ,6ʹ‐tri(4‐pyridyl)pyridine supramolecular network and calf thymus DNA, which is negatively charged due to the phosphate backbone . This platform allowed efficient stabilization of Ag NPs photochemically synthesized under the direct exposure of sunlight.…”

Section: Biomedical Applications Of Dna Hydrogelsmentioning

confidence: 97%

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

Shahbazi

Bauleth‐Ramos

Santos

2018

Advanced Therapeutics

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DNA is a perfect polymeric molecule for interfacing biology with material science to construct hydrogels that represent fascinating properties for a wide variety of biomedical applications. Tunable multifunctionality, convenient programmability, adequate biocompatibility, biodegradability, capability of precise molecular recognition, and high versatility have made DNA an irreplaceable building block for the construction of novel 3D hydrogels. DNA can be used as the only component of a hydrogel, the backbone or a cross-linker that connects the main building blocks to form hybrid hydrogels through chemical reactions or physical entanglement. Responsive constructs of DNA with superior mechanical properties are very commonly reported nowadays, which can undergo macroscopic changes induced by various triggers, including alteration in ionic strength, temperature, and pH. These hydrogels can be prepared by various types of DNA building blocks, such as branched double-stranded DNA, single-stranded DNA, X-shaped DNA, or Y-shaped DNA through intermolecular i-motif structures, DNA hybridization, enzyme ligation, or enzyme polymerization. These hydrogels are envisioned for a variety of applications, such as drug delivery, sensing, tissue engineering, 3D cell culture, and providing template for nanoparticle synthesis.

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“…Gels are soft‐viscoelastic 3D scaffolds materialized through the self‐assembly of molecules by immobilizing high throughput of trapped solvent (both organic and aqueous) via different supramolecular non‐covalent intermolecular interactions like solvo‐phobic, ionic, hydrogen bonding, halogen bonding, aryl moiety based stacking features, van der Waals, etc Low‐molecular‐weight gelators (LMWGs), a special type small molecules having molecular mass of typically less than 3000, are brilliantly potent to immobilize solvents to get chemical constituents‐based semi‐solid 3D gel materials . Literary, LMWGs based gelation process basically offers supramolecular gel materials full of inter‐connected non‐covalent facets .…”

Section: Introductionmentioning

confidence: 99%

A Supramolecular Gel of Oxalic Acid‐Monoethanolamine for Potential Schottky Barrier Diode Application

et al. 2019

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A functional supramolecular gel of oxalic acid and monoethanolamine (OXMEA) has been achieved through direct instant mixing of N,N-dimethyl formamide (DMF) solution of oxalic acid and pure monoethanolamine at room temperature under ambient condition. The rheological analysis established the viscoelastic semi-solid type nature of mechanically stable OXMEA supramolecular gel. The morphological pattern, imaged through field emission scanning electron microscopic investigation, explores the bean-seed like hierarchical architecture of the gel network. The semiconducting property of the gel was verified from band gap energy and conductivity estimation. The electrical charge transport property was also analyzed in the form of OXMEA gel based metal-semiconductor junction thin film device. The obtained nonlinear current-voltage characteristics of the device signify Schottky barrier diode nature of the synthesized gel. Overall, this work has been proof of development of semiconducting electronic device by OXMEA gel based gel medium.

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A supramolecular hydrogel for generation of a benign DNA-hydrogel

Abstract: A DNA-hydrogel, produced using calf-thymus DNA and a 2′,4′,6′-tri(4-pyridyl)pyridine based luminescent supramolecular hydrogel, can stabilize sunray mediated photochemically synthesized bio-compatible, luminous Ag-NPs.

Cited by 29 publications

References 33 publications

Chitosan biopolymer functionalized gold nanoparticles with controlled cytotoxicity and improved antifilarial efficacy

Chitosan biopolymer functionalized gold nanoparticles with controlled cytotoxicity and improved antifilarial efficacy

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

A Supramolecular Gel of Oxalic Acid‐Monoethanolamine for Potential Schottky Barrier Diode Application

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