A survey of methicillin-resistant Staphylococcus aureus affecting patients in England and Wales

Kerr, Stephen J.; Kerr, Genevieve; Mackintosh, C.A.; Marples, R. R.

doi:10.1016/0195-6701(90)90047-r

Cited by 88 publications

(49 citation statements)

References 15 publications

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“…New ampoules were opened for this study and the phage type of the strain at routine test dilution (RTD) confirmed [2]. Additional phage typing at 100 x RTD with the international set and at RTD with a supplementary phage set was also carried out [5].…”

Section: Methodsmentioning

confidence: 99%

“…Phage typing, organized internationally since the 1950s, fulfilled these criteria [2], but the international phage set, because of its derivation, is most useful for strains of Northern European origin. Many antibiotic resistant strains of S. aureus found in Britain and Europe are indeed phage typable [3][4][5]. However, elsewhere in the world this may not be the case.…”

Section: Introductionmentioning

confidence: 99%

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Ribotyping ofStaphylococcus aureus: an assessment using well–defined strains

Richardson

Aparicio²,

Marples³

et al. 1994

Epidemiol. Infect.

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SUMMARYRibotyping, with homologous or heterologous (Escherichia coli) r-RNA, of the propagating strains for phages of the international set for strains of Staphylococcus aureus of human origin was undertaken to determine the discrimination of this typing method. Ribotyping could distinguish between strains of different phage groups, but could not distinguish between seven phage group III strains of different phage type. Ribotyping may be a useful adjunct to phage typing in S. aureus but is unlikely to replace it as the primary method of epidemiological typing.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ribotyping ofStaphylococcus aureus: an assessment using well–defined strains

Richardson

Aparicio²,

Marples³

et al. 1994

Epidemiol. Infect.

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“…Isolates typing only with these phages formed the 'Experimental' phage group. Antibiotic resistance to penicillin, tetracycline, erythromycin, fusidic acid, kanamycin, gentamicin and methicillin was assessed by a standard disk method [17].…”

Section: Microbiological Methodsmentioning

confidence: 99%

Enterotoxins and toxic-shock syndrome toxin-1 in non-enteric staphylococcal disease

Marples¹,

Wieneke

1993

Epidemiol. Infect.

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SUMMARYOver the 7 years 1985-91, 997 strains of Staphylococcus aureus from 962 patients with diseases other than food poisoning have been tested for the production of enterotoxins and toxic shock syndrome toxin-I (TSST-1) and phage typed. In all, 128 cases could be classified as confirmed or probable toxic shock syndrome (TSS) but a further 199 cases were classified as possible or unconfirmed TSS. In 219 cases, an alternative diagnosis could be supported and 45 cases were classified as sudden infant death syndrome. In 371 cases, insufficient information for classification was available.Strains of phage group I producing TSST-1 were associated with menstrual TSS. Many menstrual TSS cases were aged less than 20 and were using nonintroducer tampons.When all strains were reviewed, strong associations were observed between

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“…Most epidemiological studies of MRSA are not longitudinal studies but are cross-sectional studies and often involve several hospitals (14). There are a few reports of long-term surveys of MRSA in one hospital (8).…”

mentioning

confidence: 99%

“…Therefore, we cannot prove an exogenous origin of the MRSA pattern VII clone rather than the local emergence from a gentamicin-resistant MRSA strain, but its presence in many hospitals in the context of the nationwide spread argues well for the first hypothesis. Epidemic MRSA strains have been described for a long time, and there have been many reports of very large outbreaks that are due to a clone and that involve hospitals in a region, a country, or a continent (5,14). MSSA strains are usually susceptible to most antibiotics except benzylpenicillin (to which 88% of isolates are resistant) and, at lower rates, macrolides-lincosamides-streptogramin B (MLS B ) (rate of inducible resistance to MLS B , 14.5%) and fluoroquinolones (to which 4.5% of isolates are resistant).…”

mentioning

confidence: 99%

Nine-Year Surveillance of Methicillin-ResistantStaphylococcus aureusin a Hospital Suggests Instability ofmecADNA Region in an Epidemic Strain

Donnio

Louvet²,

Preney³

et al. 2002

J Clin Microbiol

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The distributions of the antibiotic resistance patterns in a population of Staphylococcus aureus isolates from a teaching hospital were studied over a 9-year period. The results indicate the existence of successive major epidemic methicillin-resistant strains and the emergence of a methicillin-susceptible strain with an unusual resistance pattern. Our findings suggest that this methicillin-susceptible S. aureus strain could be derived from the dominant gentamicin-susceptible methicillin-resistant S. aureus strain with the loss of a 40-kb DNA fragment.

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A survey of methicillin-resistant Staphylococcus aureus affecting patients in England and Wales

Cited by 88 publications

References 15 publications

Ribotyping ofStaphylococcus aureus: an assessment using well–defined strains

Ribotyping ofStaphylococcus aureus: an assessment using well–defined strains

Enterotoxins and toxic-shock syndrome toxin-1 in non-enteric staphylococcal disease

Nine-Year Surveillance of Methicillin-ResistantStaphylococcus aureusin a Hospital Suggests Instability ofmecADNA Region in an Epidemic Strain

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