A survey on the occurrence of ochratoxin A in feeds for swine and laying hens

Martins, H. Marina; Almeida, Inês; Costa, José M.; Bernardo, Fernando

doi:10.1007/s12550-011-0118-3

Cited by 21 publications

(14 citation statements)

References 14 publications

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“…For example, OTA concentrations found in animal feed ranged from 0.013 to 0.027 μM (Reyes-Velázquez et al 2008;Martins et al 2012), which were determined to be much lower than the concentration, 12.88 μM, used in the present study. OTA concentrations lower than 3.22 μM did not affect the BoMac proliferation, and IC25s were chosen to provide the similar stress levels across different PMs in this study.…”

Section: Discussionmentioning

confidence: 51%

In vitro exposure of Penicillium mycotoxins with or without a modified yeast cell wall extract (mYCW) on bovine macrophages (BoMacs)

Quinton

Boermans

et al. 2015

Mycotoxin Res

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Penicillium mycotoxins (PMs) are contaminants that are frequently found in grain or crop-based silage for animal feed. Previously, we have characterized the potential immunotoxicity of the following PMs: citrinin (CIT), ochratoxin A (OTA), patulin (PAT), mycophenolic acid (MPA), and penicillic acid (PA) by using a bovine macrophage cell line (BoMacs). In the present study, cell proliferation was used as a bioassay endpoint to evaluate the efficacy of a modified yeast cell wall extract (mYCW), for preventing PM toxicity under various in vitro conditions such as the following: pH (3, 5, 7), incubation time (1, 2, 4, 6 h), percentage of mYCW (0.05, 0.1, 0.2, 0.5, 1.0 %), and PM concentration. mYCW was most effective in preventing the toxicity of 12.88 and 25.8 μM OTA at pH 3.0 (p < 0.0001), regardless of incubation time (p < 0.0001) and the percentage of mYCW (p < 0.0001). An incubation time of 6 h (p < 0.05) or 0.5 and 1.0 % mYCW (p < 0.0001) significantly improved the efficacy of mYCW for preventing CIT toxicity. In contrast, 0.5 and 1.0 % of mYCW appeared to exacerbate the PAT toxicity (p < 0. 0001). This effect on PAT toxicity was constantly observed with higher PAT concentrations, and it reached significance at a concentration of 0.70 μM (p < 0.0001). mYCW had no effect on PA toxicity. These results suggest that mYCW may reduce OTA toxicity and, to some extent, CIT toxicity at pH 3.0. Although PAT toxicity was increased by mYCW treatment, PAT is readily degraded during heat treatment and may therefore be dealt with using other preventative measures.

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Section: Discussionmentioning

confidence: 51%

In vitro exposure of Penicillium mycotoxins with or without a modified yeast cell wall extract (mYCW) on bovine macrophages (BoMacs)

Quinton

Boermans

et al. 2015

Mycotoxin Res

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“…Apenas uma amostra de milho e uma de semente de algodão estavam contaminadas com OTA acima de 5 e 10 μg Kg -1 , respectivamente. Em estudo realizado por Martins et al (2012) em Portugal foi avaliada a contaminação por OTA em 186 amostras de ração para galinhas poedeiras. OTA foi detectada em 12 amostras (6,41 %) com concentrações de 3 a 4 μg Kg -1 .…”

Section: Efeitos Tóxicológicos Em Avesunclassified

“…A contaminação de rações destinadas à alimentação de aves por aflatoxinas, fumonisinas e ocratoxina A tem sido reportada em todo mundo (BEG et al, 2006;JAIMEZ et al, 2004;MARTINS et al, 2012;OLIVEIRA et al, 2006). Considerando que as micotoxinas não podem ser removidas pelo processamento industrial, e a exposição crônica das aves pode acarretar sérios prejuízos econômicos para produtores dos animais, além de diminuir a qualidade da carne, ovos e derivados, a avaliação da presença de micotoxinas em rações é de grande importância, a fim de minimizar seus efeitos adversos.…”

Section: Introductionunclassified

Impacto das Fumonisinas, Aflatoxinas e Ocratoxina A na Avicultura

Bordini¹,

Rossi²,

Hirooka³

et al. 2013

BBR

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Brazil is the third largest producer of poultry in the world and the leading exporter. However, mycotoxin contamination in corn and feed can cause serious economic losses to the poultry industry. Mycotoxins have been linked to several poultry diseases and, when metabolized may occur in meat and eggs and are an additional source for human contamination. Therefore, continuous monitoring of mycotoxin levels in the feed producing chain is essential to increase productivity, ensure poultry product quality and minimize human health hazards. The aim of this study was to revise the main aspects of mycotoxins (fumonisin, aflatoxins and ochratoxin A), including the producing fungi, the biosynthesis pathway, the toxicological effects in poultry and occurrence in corn and poultry feed Keywords: fumonisins, aflatoxins, ochratoxin A, chicken, corn RESUMOO Brasil é o terceiro produtor mundial de aves e o líder em exportações. No entanto, a contaminação de milho e rações por micotoxinas pode acarretar grandes perdas econômicas à avicultura. As micotoxinas estão associadas a diversos efeitos tóxicos em aves e, ao serem metabolizadas, podem ocorrer em carne e ovos, constituindo um risco para a saúde humana. Portanto, o monitoramento contínuo de micotoxinas na cadeia produtiva de rações é essencial para aumentar a produtividade, assegurar a qualidade do produto e minimizar os riscos à saúde humana. Este estudo teve como objetivo revisar os principais aspectos das micotoxinas (fumonisinas, aflatoxinas e ocratoxina A), incluindo os fungos produtores, via de biossíntese, efeitos toxicológicos em aves e a ocorrência em milho e rações de aves.Palavras-chave: fumonisinas, aflatoxinas, ocratoxina A, aves, rações BBR -Biochemistry and Biotechnology Reports

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“…Among ochratoxins, ochratoxin A (OTA) presents the highest toxicity. OTA is primarily nephrotoxic mycotoxin, which frequently co‐occurs in various foodstuffs, such as corn silage, barley, oats, rye, and wheat . Besides nephrotoxicity, OTA shows potent hepatotoxin, immunotoxin, and genotoxin in animals and humans .…”

Section: Introductionmentioning

confidence: 99%

Effects of ochratoxin A on ER stress, MAPK signaling pathway and autophagy of kidney and spleen in pigs

Gan

Hou

Zhou

et al. 2017

Environmental Toxicology

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Ochratoxin A (OTA), a worldwide mycotoxin found in food and feeds, is a potent nephrotoxin and immunotoxin in animals and humans. This research was conducted to evaluate whether endoplasmic reticulum (ER) stress, MAPK signaling pathway and autophagy were induced by OTA in kidney and spleen of pigs. Twenty-seven crossbred pigs randomly allocated to 3 groups were fed for 42 days ad libitum a basal diet without (Con group, 0.00 μg OTA/kg) and with supplementation of OTA at 400 (OTA-L group) and 800 μg/kg (OTA-H group). From each group, 6 pigs were randomly selected for blood collection on days 0, 21, and 42 and 3 pigs were randomly selected for tissue collection on day 42. The results showed that OTA at 400 and 800 μg/kg diets significantly increased OTA concentrations in serum and kidney and spleen induced the histopathological lesions of kidney and spleen, decreased TCR-stimulated T lymphocyte viabilities and IL-2 concentration, increased TNF-α concentration, and decreased T-AOC levels. OTA increased glucose regulated protein 78, p38, and ERK1/2 phosphorylation, and LC3 II and Atg5 protein expression in kidney and spleen of pigs. These results provide new insights into the relationship between OTA and ER stress, p38 and ERK1/2 MAPK signaling pathway and autophagy in pigs.

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A survey on the occurrence of ochratoxin A in feeds for swine and laying hens

Cited by 21 publications

References 14 publications

In vitro exposure of Penicillium mycotoxins with or without a modified yeast cell wall extract (mYCW) on bovine macrophages (BoMacs)

In vitro exposure of Penicillium mycotoxins with or without a modified yeast cell wall extract (mYCW) on bovine macrophages (BoMacs)

Impacto das Fumonisinas, Aflatoxinas e Ocratoxina A na Avicultura

Effects of ochratoxin A on ER stress, MAPK signaling pathway and autophagy of kidney and spleen in pigs

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