A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides

Xiao, Rong; Wang, Wenrui; Pan, Longlong; Zhu, Rongrong; Yu, Yongchun; Li, Huiping; Liu, Hui; Wang, Shilong

doi:10.1007/s10853-010-5118-8

Cited by 26 publications

(14 citation statements)

References 49 publications

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“…The neutralizing and buffering capabilities of VP16-LDH nanohybrids may come from the hydroxyl groups in its layers, and this function verifies LDH's effective role of antacid, which is also described in our previous study. 26,27,44 A three-phase release process can be observed. At the first stage with additive of HCl, the exfoliation of LDH particles was made by HCl to induce the integrity of the coating layer destroyed, which resulted in sharp decrement of solution pH from about 9.5-5.5.…”

Section: Buffer Effect Of Vp16-ldhmentioning

confidence: 95%

“…Furthermore, the major weight loss of VP16-LDH in temperatures ranging from 300°C-400°C was approximately 24.01%, which is similar to the loading amount of VP16 measured by UV-VIS spectroscopy. 26,27 Particle size distribution and TEM examination…”

Section: Fourier Transform Infrared (Ftir) and Thermal Stability Analmentioning

confidence: 99%

“…Their low cost, good biocompatibility, low toxicity to mammalian cells, controlled-release system, and ability to provide full protection for loaded drugs make them suitable candidates for drug delivery systems. 11,12 Many LDH compounds intercalated with beneficial organic anions, such as deoxyribonucleic acid DNA, [13][14][15][16] amino acids, [17][18][19][20][21][22] anionic polymers, 23 pesticides, 24,25 and drugs, [26][27][28][29][30] have been prepared successfully. Special interests have focused on exploring the possibilities of using LDH drug delivery systems to deliver antiinflammatory drugs, 31 anticoagulants like heparin, 32 or anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

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The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids

Qin¹,

Wang²,

Zhu³

et al. 2013

IJN

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Magnesium-aluminum layered double hydroxides intercalated with antitumor drug etoposide (VP16) were prepared for the first time using a two-step procedure. The X-ray powder diffraction data suggested the intercalation of VP16 into layers with the increased basal spacing from 0.84-1.18 nm was successful. Then, it was characterized by X-ray powder diffraction, Fourier transform infrared spectroscopy, thermogravimetry and differential thermal analysis, and transmission electron microscopy. The prepared nanoparticles, VP16-LDH, showed an average diameter of 62.5 nm with a zeta potential of 20.5 mV. Evaluation of the buffering effect of VP16-LDH indicated that the nanohybrids were ideal for administration of the drugs that treat human stomach irritation. The loading amount of intercalated VP16 was 21.94% and possessed a profile of sustained release. The mechanism of VP16-LDH release in the phosphate buffered saline solution at pH 7.4 is likely controlled by the diffusion of VP16 anions from inside to the surface of LDH particles. The in vitro cytotoxicity and antitumor assays indicated that VP16-LDH hybrids were less toxic to GES-1 cells while exhibiting better antitumor efficacy on MKN45 and SGC-7901 cells. These results imply that VP16-LDH is a potential antitumor drug for a broad range of gastric cancer therapeutic applications.

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Section: Buffer Effect Of Vp16-ldhmentioning

confidence: 95%

Section: Fourier Transform Infrared (Ftir) and Thermal Stability Analmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids

Qin¹,

Wang²,

Zhu³

et al. 2013

IJN

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“…Currently, many inorganic materials are being used for inorganic drug delivery (for instance, carbon materials, calcium phosphate, layered double hydroxide, gold, iron oxide, and silicon oxide [29][30][31][32][33][34] ), but for the most part these initiatives have been unsatisfactory. Critical properties of inorganic nanocarriers include nonbiodegradability, high leakage of drugs, and poor cellular internalization, which affect their efficiency in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release

Qian¹,

Sun²,

Zhu³

et al. 2012

IJN

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Strontium carbonate nanoparticles (SCNs), a novel biodegradable nanosystem for the pH-sensitive release of anticancer drugs, were developed via a facile mixed solvent method aimed at creating smart drug delivery in acidic conditions, particularly in tumor environments. Structural characterization of SCNs revealed that the engineered nanocarriers were uniform in size and presented a dumbbell-shaped morphology with a dense mass of a scale-like spine coating, which could serve as the storage structure for hydrophobic drugs. Chosen as a model anticancer agent, etoposide was effectively loaded into SCNs based on a simultaneous process that allowed for the formation of the nanocarriers and for drug storage to be accomplished in a single step. The etoposide-loaded SCNs (ESCNs) possess both a high loading capacity and efficient encapsulation. It was found that the cumulative release of etoposide from ESCNs is acid-dependent, and that the release rate is slow at a pH of 7.4; this rate increases significantly at low pH levels (5.8, 3.0). Meanwhile, it was also found that the blank SCNs were almost nontoxic to normal cells, and ESCN systems were evidently more potent in antitumor activity compared with free etoposide, as confirmed by a cytotoxicity test using an MTT assay and an apoptosis test with fluorescence-activated cell sorter (FACS) analysis. These findings suggest that SCNs hold tremendous promise in the areas of controlled drug delivery and targeted cancer therapy.

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“…9,10 They possess some promising advantages such as low cost, good biocompatibility, low toxicity to mammalian cells, controlled release property, and full protection for loaded drugs. Many LDH compounds intercalated with beneficial organic anions such as DNA, 11,12 amino acids, 13 anionic polymers, 14 pesticides, 15 and drugs [16][17][18][19] have been prepared successfully. Furthermore, the antioxidant intercalated into LDH delivery can be used as a nanomaterial antioxidant supplementation, thereby expanding its range of applications.…”

mentioning

confidence: 99%

In vitro antioxidant activity and in vivo antifatigue effect of layered double hydroxide nanoparticles as delivery vehicles for folic acid

Qin

Wang

You

et al. 2014

IJN

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Folic acid antioxidants were successfully intercalated into layered double hydroxides (LDH) nanoparticles according to a previous method with minor modification. The resultant folic acid-LDH constructs were then characterized by X-ray powder diffraction and transmission electron microscopy. The in vitro antioxidant activities, cytotoxicity effect, and in vivo antifatigue were examined by a series of assays. The results showed that folic acid-LDH antioxidant system can scavenge 1,1-diphenyl-2-picrylhydrazyl and hydroxyl free radicals and chelate pro-oxidative Cu 2+ . The in vitro cytotoxicity assays indicated that folic acid-LDH antioxidant system had no significant cytotoxic effect or obvious toxicity to normal cells. It also prolonged the forced swimming time of the mice by 32% and 51% compared to folic acid and control groups, respectively. It had an obvious effect on decreasing the blood urea nitrogen and blood lactic acid, while increasing muscle and hepatic glycogen levels. Therefore, folic acid-LDH might be used as a novel antioxidant and antifatigue nutritional supplement.

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A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides

Cited by 26 publications

References 49 publications

The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids

The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids

pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release

In vitro antioxidant activity and in vivo antifatigue effect of layered double hydroxide nanoparticles as delivery vehicles for folic acid

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