A swellable hydrogel microneedle based on cerium-metal organic frame composite nanozyme for detection of biomarkers

Zhao, Jiuhong; Lv, Jiatong; Ling, Guixia; Zhang, Peng

doi:10.1016/j.ijbiomac.2023.127745

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…Moreover, the results obtained in vivo were comparable to the ones obtained for blood using a commercial kit. This platform represents an alternative to currently available test kits for glutathione, which are expensive and nonreusable, 150 and we believe it holds great promise for the application to other metabolic diseases, such as hemochromatosis, which is characterized by high levels of ferritin. 151 MN-based monitoring devices can also be used to detect various substances, from medicines to illicit drugs.…”

Section: Isf Collecting Devicesmentioning

confidence: 99%

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Pereira,

Vinayakumar,

Sillankorva

2024

ACS Sens.

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Bioanalyte collection by blood draw is a painful process, prone to needle phobia and injuries. Microneedles can be engineered to penetrate the epidermal skin barrier and collect analytes from the interstitial fluid, arising as a safe, painless, and effective alternative to hypodermic needles. Although there are plenty of reviews on the various types of microneedles and their use as drug delivery systems, there is a lack of systematization on the application of polymeric microneedles for diagnosis. In this review, we focus on the current state of the art of this field, while providing information on safety, preclinical and clinical trials, and market distribution, to outline what we believe will be the future of health monitoring.

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Section: Isf Collecting Devicesmentioning

confidence: 99%

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Pereira,

Vinayakumar,

Sillankorva

2024

ACS Sens.

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“…An innovative approach features a swellable hydrogel microneedle composed of polyvinyl alcohol and sodium alginate, integrated with a cerium–metal organic framework composite nanozyme for detecting critical biomarkers, such as glutathione. This microneedle-based system offers rapid and minimally invasive detection of biomarkers in interstitial fluid, showing significant promise for in vivo applications and potentially enhancing diagnostic procedures considerably [ 24 ].…”

Section: Biomedical Applications Sensing and Monitoringmentioning

confidence: 99%

“…Chemical Crosslinking: This prevalent method creates swellable microneedles, such as hydrogel MNs based on cerium–metal organic framework composite nanozymes, for biomarker detection [ 24 ]. Additionally, hydrogel MNs integrated with aptamer probes and fluorescence detection for reagentless biomarker quantification have been developed using chemical attachment during crosslinking [ 59 ].…”

Section: Processes Involved In the Manufacturing Of Swellable Microne...mentioning

confidence: 99%

“…Advanced Applications and Sensing Capabilities: For more advanced applications, integrating MNs with biosensors can significantly enhance their functionality by enabling real-time detection of biomarkers, such as glucose or specific nucleic acids [ 19 , 21 , 24 , 25 , 29 , 57 , 59 , 61 , 63 ]. This integration fosters the development of responsive MN systems that adapt drug delivery based on physiological changes.…”

Section: Tests and Assessmentsmentioning

confidence: 99%

“…Methacrylated hyaluronic acid (MeHA) supports rapid interstitial fluid (ISF) extraction, structural integrity, and metabolic analysis [ 23 ]. Polyvinyl alcohol (PVA) combined with sodium alginate (SA) exhibits high oxidase-like activity, rapid extraction, and colorimetric detection [ 24 ]. The swellable bilateral core–shell structure allows for rapid absorption, selective reaction, and accurate lactate sensing [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Swellable Microneedles in Drug Delivery and Diagnostics

Omidian,

Dey Chowdhury

2024

Pharmaceuticals

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This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs in medical treatment and monitoring. Innovations in hydrogel-integrated MN arrays facilitate controlled drug release, thereby expanding treatment options for chronic diseases and conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, and manufacturing processes, as well as achievements in advanced manufacturing, biocompatibility, and versatile applications. Nonetheless, limitations in physiological responsiveness and long-term stability remain, necessitating further research in material innovation and integration with digital technologies. Future directions focus on expanding biomedical applications, material advancements, and regulatory considerations for widespread clinical adoption.

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