A Sword with Two Edges: The Role of Children's Literature in the Writings of N. K. Krupskaia

Raymond, Boris

doi:10.1086/620274

Cited by 24 publications

(7 citation statements)

References 5 publications

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“…Carboxylation of the hydroxypyridinone ring ortho to the phenolate oxygen gives a geometry which is favorable for metal-binding and adds to chelate stability via hydrogen-bond formation. , The amide−phenol hydrogen bond also lowers the protonation constant of the phenolate from 8.66 for 3,2-HOPO 5 to 6.12 for N -methyl-4-propylamide-3,2-HOPO. , Aromaticity of the ring is enhanced, and it becomes more resistant to oxidation and reduction (e.g., N -methyl-3,2-HOPO is easily reduced to 3-hydroxy-2-piperidone 8 ). Carboxylation at the desired 4-position in 3,2-hydroxypyridinone ligands may be directed by prior alkylation of the ring nitrogen. , …”

Section: Introductionmentioning

confidence: 99%

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size¹

O’Sullivan

Raymond

2002

Inorg. Chem.

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TREN-Me-3,2-HOPO, TR322-Me-3,2-HOPO, TR332-Me-3,2-HOPO, and TRPN-Me-3,2-HOPO correspond to stepwise replacement of ethylene by propylene bridges. A series of tripodal, hexadentate hydroxypyridinone ligands are reported. These incorporate 1-methyl-3,2-hydroxypyridinone (Me-3,2-HOPO) bidentate chelating units for metal binding. They are varied by systematic enlargement of the capping scaffold which connects the binding units. The series of ligands and their iron complexes are reported. Single crystal X-ray structures are reported for the ferric complexes of all four tripodal ligands: FeTREN-Me-3,2-HOPO.0.375C(4)H(10)O.0.5CH(2)Cl(2) [P2(1)/n (No. 14), Z = 8, a = 20.478(3) A, b = 12.353(2) A, c = 27.360(3) A; beta = 91.60(1) degrees ]; FeTR322-Me-3,2-HOPO.CHCl(3).0.5C(6)H(14).CH(3)OH.0.5H(2)O [P2(1)/n (No. 14), Z = 4, a = 12.520(3) A, b = 22.577(5) A, c = 16.525(3) A; beta = 111.37(3) degrees ]; FeTR332-Me-3,2-HOPO.3.5CH(3)OH [C2/c (No. 15), Z = 8, a = 13.5294(3) A, b = 19.7831(4) A, c = 27.2439(4) A; beta = 101.15(3) degrees ]; FeTRPN-Me-3,2-HOPO.C(3)H(7)NO.2C(4)H(10)O [P1 (No. 2), Z = 2, a = 11.4891(2) A, b = 12.3583(2) A, c = 15.0473(2) A; alpha = 86.857(1) degrees, beta = 88.414(1) degrees, gamma = 70.124(1) degrees ]. The structures show the importance of intermolecular hydrogen bonds and the effect of cap enlargement to the stability and geometry of the metal complexes throughout the series. All protonation and iron complex formation constants have been determined from solution thermodynamic studies. The TREN-capped derivative is the most acidic, with a cumulative protonation constant, log beta(014), of 25.95. Corresponding values of 26.35, 26.93, and 27.53 were obtained for the TR322, TR332, and TRPN derivatives, respectively. The protonation constants and NMR spectroscopic data are interpreted as being due to the influence of specific hydrogen-bond interactions. The incremental enlargement of ligand size results in a decrease in iron-chelate stability, as reflected in the log beta(110) values of 26.8, 26.2, 26.42, and 24.48 for the TREN, TR322, TR332, and TRPN derivatives, respectively. The metal complex formation constants are also affected by the acidity of a proximal (non-metal-binding) amine in the complexes, a trend consistent with the effects of internal hydrogen bonding. The ferric complexes display reversible reduction potentials (measured relative to the normal hydrogen electrode (NHE)) between -0.170 and -0.223 V.

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Section: Introductionmentioning

confidence: 99%

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size¹

O’Sullivan

Raymond

2002

Inorg. Chem.

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“…The mixed Me-3,2-HOPO and 1,2-HOPO ligand in 2 was prepared via a method similar to that previously reported …”

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confidence: 99%

Gadolinium(III) 1,2-Hydroxypyridonate-Based Complexes: Toward MRI Contrast Agents of High Relaxivity¹

Churchill

Botta

et al. 2004

Inorg. Chem.

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Prospective gadolinium(III) MRI contrast agent precursors [Gd-TREN-1,2-HOPO] (1) [TREN-1,2-HOPO = tris[(1-hydroxy-2-oxo-1,2-dihydropyridine-6-carboxamido)ethyl]amine] and [Gd-TREN-bis(Me-3,2-HOPO)-1,2-HOPO] (2) have been synthesized and characterized by relaxometric measurements. The water proton relaxivity values of 1 and 2 (20 MHz and 25 degrees C) are 9.5 and 9.3 mM(-)(1)s(-)(1), respectively, suggesting the presence of two coordinated water molecules. The molecular structure of [1.DMF](2) was obtained and reveals a similar eight-coordinate geometry to [Gd-TREN-Me-3,2-HOPO.2H(2)O] ([3.2H(2)O]). A shape analysis of the coordination polyhedron of 1 reveals that this geometry is best described as a bicapped trigonal prism, poised to accommodate an additional donor atom to give a tricapped trigonal prismatic intermediate. This geometry supports the model that formation of a tris-aquo intermediate for 1 enables fast and associative water exchange.

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“…A obra de Krupskaya foi pouco divulgada no ocidente, mas de acordo com Raymond (1974), seus escritos foram sendo divulgados ligados a biografia de Lenin e a literatura infantil (MC NEAL, 1973). Em Artigos sua atuação como educadora e política ligada ao movimento revolucionário, ala fez usou de sua persuasão ideológica e intervenção administrativa em sua capacidade de principal autoridade comunista.…”

Section: Contexto Histórico E Biografia De E Krupskaya E Pistrakunclassified

“…Com a ajuda da auto-organização as crianças aprendem a encontrar formas de ação conjuntas, as quais devem refletir na vida comum e no trabalho coletivo da comunidade escolar" (KRUPSKAYA, 2017, p. 115). O excerto acima vai ao encontro das análises de Raymond (1974), Skatkin e Tsov'janov (1994) e Silva (2012), no qual apontam que Krupskaya objetiva que a escola do rabalho formaria o homem revolucionário em articulação com o trabalho físico e intelectual, de ensino politécnico.…”

Section: A Auto-organização Em Krupskayaunclassified

“…Em adição, foi realizada uma investigação bibliográfica na literatura acadêmica nacional e internacional para se compreender de maneira mais profunda o contexto do período em questão e sobre as obras dos pensadores investigados, procedendo conforme apontado por Pizzani et al (2012). A investigação bibliográfica gerou informações relevantes sobre a área do conhecimento aqui pesquisa, bem como forneceu subsídios para a redação do presente trabalho científico, permitindo uma aproximação com diversos trabalho do campo (FEITOSA, 2018;MC NEAL, 1973;MUÑOZ-MUÑOZ, 2010;RAYMOND, 1974;SKATKIN;TSOV'JANOV, 1994;SILVA, 2012;GOLOVATY, 2017a;GOLOVATY, 2017b;CALDART, 2005;BOLEIZ JÚNIOR, 2017).…”

Section: Introductionunclassified

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Auto-organização da escola do trabalho em Krupskaya e Pistrak: análise inicial sobre a autogestão estudantil a partir da experiência pedagógica soviética.

Praciano

Feitosa

2020

Germinal

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A auto-organização, categoria da pedagogia soviética, é caracterizada como uma forma de estruturação da vida estudantil dos jovens. O objetivo da pesquisa é analisar a auto-organização na escola do trabalho através das obras de Moisey M. Pistrak e Nadejda K. Krupskaya. Para isso, foi realizada uma análise documental das obras dos pedagogos soviéticos e uma bibliográfica direcionada ao contexto histórico, como também as contribuições da literatura referente ao assunto. Os resultados indicam que para os educadores russos a autodireção é capaz de proporcionar aos estudantes concepções sobre organização, autonomia e coletividade. Por fim, considera-se necessário estudos aprofundados sobre as obras de Krupskaya e Pistrak.

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A Sword with Two Edges: The Role of Children's Literature in the Writings of N. K. Krupskaia

Cited by 24 publications

References 5 publications

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size¹

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size¹

Gadolinium(III) 1,2-Hydroxypyridonate-Based Complexes: Toward MRI Contrast Agents of High Relaxivity¹

Auto-organização da escola do trabalho em Krupskaya e Pistrak: análise inicial sobre a autogestão estudantil a partir da experiência pedagógica soviética.

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A Sword with Two Edges: The Role of Children's Literature in the Writings of N. K. Krupskaia

Cited by 24 publications

References 5 publications

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size1

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size1

Gadolinium(III) 1,2-Hydroxypyridonate-Based Complexes: Toward MRI Contrast Agents of High Relaxivity1

Auto-organização da escola do trabalho em Krupskaya e Pistrak: análise inicial sobre a autogestão estudantil a partir da experiência pedagógica soviética.

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Resources

About

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size¹

Hexadentate Hydroxypyridonate Iron Chelators Based on TREN-Me-3,2-HOPO: Variation of Cap Size¹

Gadolinium(III) 1,2-Hydroxypyridonate-Based Complexes: Toward MRI Contrast Agents of High Relaxivity¹