For years, human resource development and management (HRDM) has used behavioral assessments to gauge employee potential. However, advancements in cognitive behavioral neuroscience (CBN) have opened up new possibilities for understanding how the human mind works. This chapter explores the practical applications of neuroscience methods like EEG, ERP, MRI, and fMRI, as well as neurofeedback and biofeedback, in talent identification, leadership development, and employee well-being. Importantly, these insights can be directly applied in HRDM practices, leading to more effective talent management, leadership development, and improved employee well-being. While recognizing the ethical considerations involved with these technologies, the chapter presents a compelling vision for a future where HRDM practices are informed by a deeper understanding of the brain, enabling the workforce to reach its full potential.