A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells

Warashina, Masaki; Min, Kyung Hoon; Kuwabara, Tomoko; Huynh, Alexis; Gage, Fred H.; Schultz, Peter G.; Ding, Sheng

doi:10.1002/anie.200503089

Cited by 101 publications

(57 citation statements)

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“…1). Today, the search for small bioactive molecules is essentially a process of trial and error, whereby large collections of compounds are either chemically synthesized or isolated from natural sources, then experimentally tested for biochemical and cellular effects (9,10,(26)(27)(28). In 2005, the Molecular Libraries Screening Center Network (MLSCN) was created as part of the NIH Roadmap Initiative (29).…”

Section: Tools For Managing Large Amounts Of Disparate Datamentioning

confidence: 99%

A Cheminformatic Toolkit for Mining Biomedical Knowledge

et al. 2007

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This article will review cheminformatic tools that can be applied to facilitate annotation of PubChem through links to the scientific literature; to integrate PubChem with transcriptomic, proteomic, and metabolomic datasets; to incorporate results of numerical simulations of physiological systems into PubChem annotation; and ultimately, to translate data of chemical genomics screening efforts into information that will benefit biomedical researchers and physician scientists across all therapeutic areas.

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Section: Tools For Managing Large Amounts Of Disparate Datamentioning

confidence: 99%

A Cheminformatic Toolkit for Mining Biomedical Knowledge

et al. 2007

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“…High throughput screening has also been used to find a compound that induces differentiation to mature neurons from neural progenitor cells [168]. A 50,000 compound heterocycle library was screened against HCN rat hippocampal primary neuronal progenitor cells.…”

Section: Small Molecule Screening Techniques Applied To Stem Cellsmentioning

confidence: 99%

Stem Cells and Combinatorial Science

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Wong²,

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et al. 2007

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Stem cell-based technologies have the potential to help cure a number of cell degenerative diseases. Combinatorial and high throughput screening techniques could provide tools to control and manipulate the self-renewal and differentiation of stem cells. This review chronicles historic and recent progress in the stem cell field involving both pluripotent and multipotent cells, and it highlights relevant cellular signal transduction pathways. This review further describes screens using libraries of soluble, small-molecule ligands, and arrays of molecules immobilized onto surfaces while proposing future trends in similar studies. It is hoped that by reviewing both the stem cell and the relevant high throughput screening literature, this paper can act as a resource to the combinatorial science community.

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“…[166] Beispielsweise wurde mit HDAC-Inhibitoren die Notwendigkeit der HDAC-Aktivität während eines spezifischen Zeitintervalls der Oligodendrozyten-Differenzierung [167] und dem Auswachsen der Zellen [168] in vitro und in vivo gezeigt. [178] und eine verbesserte Hirnpenetration hatte. Bei systemischer Gabe an adulte Ratten steigerte dieses Molekül die neuronale Differenzierung.…”

Section: Gerichtete Differenzierung Von Nscs Mit Bekannten Modulatoreunclassified

Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen

et al. 2010

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Mögliche Anwendungen von Stammzellen in der Medizin reichen von der Modellierung von Krankheiten und der Wirkstoffsuche bis hin zu Zelltransplantation und regenerativen Therapien. Bevor diese Versprechen jedoch eingelöst werden können, müssen noch einige Hindernisse überwunden werden, unter anderem die Kontrolle der Stammzelldifferenzierung, die allogene Abstoßung und die eingeschränkte Zellverfügbarkeit. Dies erfordert ein vertieftes Verständnis der Mechanismen, die das Stammzellpotenzial kontrollieren, und die Entwicklung robuster Methoden, um das Schicksal von Stammzellen effizient zu steuern. In der letzten Zeit wurden eine Reihe niedermolekularer Verbindungen entdeckt, die in vitro und in vivo verwendet werden können, um Stammzellen zu expandieren, ihre Differenzierung zu dirigieren oder somatische Zellen in ein naiveres Stadium zu reprogrammieren. Diese Moleküle haben tiefe Einblicke in Signalwege und epigenetische Mechanismen ermöglicht, die die Stammzellbiologie regulieren, und sie beginnen bereits, zur Entwicklung effizienter Behandlungen für Gewebereparatur und –regeneration beizutragen.

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A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells

Cited by 101 publications

References 10 publications

A Cheminformatic Toolkit for Mining Biomedical Knowledge

A Cheminformatic Toolkit for Mining Biomedical Knowledge

Stem Cells and Combinatorial Science

Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen

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