A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis

Paraskevas, S.P.; Huizinga, John D.; Loos, Bruno G.

doi:10.1111/j.1600-051x.2007.01173.x

Cited by 632 publications

(640 citation statements)

References 88 publications

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“…Although the levels of CRP did not decrease significantly, the mean decrease after 12 months (0.45 g/L) is comparable to data presented in a recent meta-analysis [18]. Whether CRP really is an independent risk factor for CVD remains debatable [19], however studies have shown that even small differences in CRP concentrations can reflect the risk of developing CVD [20].…”

Section: Discussionsupporting

confidence: 76%

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

et al. 2009

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a b s t r a c tThis study investigated the effect of mechanical infection control for periodontitis and periodontal surgery on the prevalence of well-established risk factors for atherosclerosis, and plasma levels of cytokines, antibodies against heat shock proteins and markers of systemic inflammation.Sixty-eight patients between 39 and 73 years of age with severe periodontitis who had been referred to four specialist periodontology clinics in Sweden were investigated. A fasting venous blood sample was taken at baseline and additional samples were collected after 3 and 12 months. A total of 54 patients underwent periodontal treatment.The periodontal treatment was successful, as pathogenic gingival pockets decreased significantly. Plasma glucose, lipids and markers of systemic inflammation were not significantly altered after 3 months. One year after the initial treatment, HDL-C concentrations were significantly increased ( 0.08 mmol/L) whereas LDL-C concentrations decreased ( 0.23 mmol/L). Haptoglobin concentrations were also lower. Interleukin-18 and interferon-␥ levels were also lower after 12 months (60 ng/L (−23%) and 11 ng/L (−97%) respectively). Treatment had no effect on plasma levels of IgA, IgG1, IgG2 antibodies against heat shock proteins.In conclusion, this study indicates that standard treatment for periodontal disease induces systemic changes in several biochemical markers that reflect the risk for atherosclerosis.

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Section: Discussionsupporting

confidence: 76%

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

et al. 2009

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“…Furthermore, there is a positive correlation between periodontal disease and obesity, hypertension, hyperlipidemia, or hyperglycemia (Zhou, Zhang, Liu, Zhang, & Li, 2015), although the molecular mechanisms of these relationships are unclear. Periodontitis is a low‐grade systemic inflammation that is reported to cause elevated systemic levels of inflammatory mediators such as C‐reactive protein and interleukin‐6 (Paraskevas, Huizinga, & Loos, 2008). A number of studies have found a similar association between an increase of C‐reactive protein or interleukin‐6 and increased mortality in dialysis patients (Zhang et al, 2013; Zimmermann et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi

Oishi

Inagaki

et al. 2016

Clinical & Exp Dental Res

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Recent studies have demonstrated that chronic kidney disease (CKD) may be associated with the progression of periodontal disease. Diabetes mellitus (DM) is a major risk factor for CKD. The objective of this study was to clarify the relationship between periodontal condition and kidney dysfunction in patients who had kidney failure with or without DM. One hundred sixty‐four patients with kidney dysfunction were enrolled (male: N = 105; female: N = 59), and the relationship between periodontal condition and kidney dysfunction was analyzed in a cross‐sectional study. The subjects were divided into three groups: (a) patients with DM, (b) dialysis patients with nephropathy due to various kidney diseases, and (c) dialysis patient with nephropathy due to DM (diabetic nephropathy). Then, the effect of DM on the periodontal condition was analyzed. The patients were also stratified by CKD stage (into G1–G5) using the estimated glomerular filtration rate (eGFR), and the G5 group was divided in patients with or without DM. Correlations between eGFR and parameters of periodontal condition were calculated in patients from G1 to G4. The number of missing teeth was significantly higher in dialysis patients with diabetic nephropathy than in patients with DM, whereas alveolar bone loss did not show a significant difference among the three groups. In addition, the G5 patients with DM had a significantly higher number of missing teeth than the other CKD groups, whereas alveolar bone loss did not show a significant difference. In G5 patients with DM, Community Periodontal Index and Oral Hygiene Index scores were significantly higher than in G1‐4 patients with DM. There was a significant negative correlation between eGFR and the number of missing teeth. Patients with diabetic nephropathy have a higher rate of periodontal problems such as missing teeth in Japanese adults.

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“…The panel adopted the nomenclature and definitions for terms used by 2001 International Sepsis Definitions [46,47] and alcohol [48] consumption, malnutrition [82,157], swallowing impairment with aspiration [45], chemotherapy-induced neutropenia [39,158,159], disruption of physiological barriers as a consequence of radiodermitis and mucositis [40,160], gingival pockets and dental caries [161][162][163][164], age [12,165,166], co-morbidities such as diabetes and chronic obstructive pulmonary disease (COPD) [166], and the presence of central venous catheters, gastrostomy and tracheostomy are at a higher risk of infections. Conference (i.e.…”

Section: Definition Of Sepsis Syndromementioning

confidence: 99%

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Mirabile

Numico²,

Russi

et al. 2015

Critical Reviews in Oncology/Hematology

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The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics

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A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis

Abstract: There is strong evidence from cross-sectional studies that plasma CRP in periodontitis is elevated compared with controls. There is modest evidence on the effect of periodontal therapy in lowering the levels of CRP.

Cited by 632 publications

References 88 publications

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

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