A systematic review and meta-analysis of neuropathic pain in multiple sclerosis: Prevalence, clinical types, sex dimorphism, and increased depression and anxiety symptoms

Rodrigues, Patrícia; da Silva, Brenda; Trevisan, Gabriela

doi:10.1016/j.neubiorev.2023.105401

Cited by 7 publications

(4 citation statements)

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“…According to previous studies, the diagnosis of neuropathic pain was mainly defined through the following methods: IASP criteria ( 15 ) AAPT criteria ( 19 ), questionnaire evaluation ( 20 ), and clinical symptoms ( 21 ). Douleur Neuropathique 4 Questions (DN4), McGill Pain Questionnaire (MPQ) and Pain Disability Questionnaire (PDQ), are the most commonly used for the diagnosis of neuropathic pain( 11 ). In Heitmann’s study, neuropathic pain was defined as PDQ ≧̸19 and the prevalence of neuropathic pain was 4.2% ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…The correlation between gender, age and neuropathic pain in patients with MS was inconsistent in previous studies. Recently, a meta-analysis surveyed 6671 MS patients and found that prevalence of neuropathic pain was higher for females (74.17%, 95% CI: 65.34; 81.38) than male patients (28.93%, 95% CI: 22.28; 36.63) ( 11 ). Meanwhile, the possible mechanisms that contribute to this phenomenon might be the influence of sex hormones, genetic and anatomical differences ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of patients with neuropathic pain in MS varies between 21% and 58%( 6 – 8 ), which interferes the quality of life domains( 3 , 5 ). There are several definitions of neuropathic pain, such as International Association for the Study of Pain (IASP) criteria( 9 ), Networks-American Pain Society Pain Taxonomy (AAPT) criteria( 10 ), and some validated questionnaires( 11 ). The IASP definition of neuropathic pain was that “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system”, which was used in our study.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study

Ouyang,

Li,

et al. 2024

Front. Immunol.

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BackgroundPain is a common symptom in multiple sclerosis (MS), especially neuropathic pain, which has a significant impact on patients’ mental and physical health and quality of life. However, risk factors that related to neuropathic pain, still remain unclear.ObjectiveThe study aimed to explore the risk factors of neuropathic pain among MS patients.Materials and methodsThis retrospective study examined the consecutive patients diagnosed with MS in the Department of Neurology of Guangdong Provincial Hospital of Chinese Medicine between August 2011 and October 2022. Neuropathic pain was defined as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system”. Demographic and clinical features were obtained from the electronic system of the hospital.ResultsOur cohort revealed that the prevalence of patients with neuropathic pain in MS was 34.1%. The results indicated that the longer the spinal lesions, the greater the neuropathic pain risks (2-4: OR, 13.3(2.1-82), >5: OR, 15.2(2.7-86.8), p for tread: 0.037). Meanwhile, multivariate regression analysis showed that cervical and thoracic lesions (OR 4.276, 95% CI 1.366-13.382, P = 0.013), upper thoracic lesions (T1-T6) (OR 3.047, 95% CI 1.018-9.124, P = 0.046) were positively correlated with neuropathic pain, while basal ganglia lesions (OR 0.188, 95% CI 0.044-0.809, P = 0.025) were negatively correlated with neuropathic pain among MS patients.ConclusionExtended spinal lesions (≥3 spinal lesions), cervical and thoracic lesions, upper thoracic lesions were independent risk factors of neuropathic pain among MS patients. Furthermore, our study found that the longer the spinal lesions, the greater the neuropathic pain risks.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study

Ouyang,

Li,

et al. 2024

Front. Immunol.

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“…A systematic review of epidemiological studies has shown that the prevalence of neuropathic pain is 6.9–10% ( van Hecke et al, 2014 ). In patients with multiple sclerosis, the incidence rate of neuropathic pain is even as high as 26.8% ( Rodrigues et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Treadmill running on neuropathic pain: via modulation of neuroinflammation

He,

Hou,

Wang

et al. 2024

Front. Mol. Neurosci.

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Neuropathic pain is a type of chronic pain caused by an injury or somatosensory nervous system disease. Drugs and exercise could effectively relieve neuropathic pain, but no treatment can completely stop neuropathic pain. The integration of exercise into neuropathic pain management has attracted considerable interest in recent years, and treadmill training is the most used among exercise therapies. Neuropathic pain can be effectively treated if its mechanism is clarified. In recent years, the association between neuroinflammation and neuropathic pain has been explored. Neuroinflammation can trigger proinflammatory cytokines, activate microglia, inhibit descending pain modulatory systems, and promote the overexpression of brain-derived neurotrophic factor, which lead to the generation of neuropathic pain and hypersensitivity. Treadmill exercise can alleviate neuropathic pain mainly by regulating neuroinflammation, including inhibiting the activity of pro-inflammatory factors and over activation of microglia in the dorsal horn, regulating the expression of mu opioid receptor expression in the rostral ventromedial medulla and levels of γ-aminobutyric acid to activate the descending pain modulatory system and the overexpression of brain-derived neurotrophic factor. This article reviews and summarizes research on the effect of treadmill exercise on neuropathic pain and its role in the regulation of neuroinflammation to explore its benefits for neuropathic pain treatment.

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