A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder

O'Doherty, Daniel C.M.; Chitty, Kate M.; Saddiqui, Sonia; Bennett, Maxwell R.; Lagopoulos, Jim

doi:10.1016/j.pscychresns.2015.01.002

Cited by 317 publications

(235 citation statements)

References 203 publications

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“…Although 2 prior meta-analytic studies of hippocampal volume in individuals with PTSD reported greater reduction in left hippocampal volume, 5,6,2 other meta-analyses did not find such effects. 4,7 The present results contribute to this body of literature by suggesting that the left-lateralized effects may be influenced by Val homozygosity.…”

Section: Discussionmentioning

confidence: 89%

“…2 Accordingly, given its role in memory encoding and consolidation and its modulatory influence on hypothalamicpituitary-adrenal (HPA) axis function, the hippocampus has long been a focus of research on the etiology and maintenance of PTSD. 3 Recent meta-analyses have found evidence for PTSD-associated reductions in hippocampal volume, [4][5][6][7] though results across studies have not been uniform, [8][9][10][11][12][13][14][15][16][17][18] suggesting that various moderating variables, including genetic factors, may influence the association between PTSD and hippocampal volume.…”

Section: Introductionmentioning

confidence: 99%

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COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

Hayes

Logue

Reagan

et al. 2017

JPN

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

Hayes

Logue

Reagan

et al. 2017

JPN

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“…A literature study comparing findings regar ding the brain volumes of patients and controls found several significant differences: PTSD was associated with reduced hippocampal and bilateral anterior cingulate cortex (ACC) volume, and a medium effect size reduction. However, no significant difference in amygdala volume was found [2] . From these results it was proposed that the volume reductions in ACC underlie the attention and emotion modulation deficits found in PTSD.…”

Section: Neurobiologymentioning

confidence: 79%

Animal models for posttraumatic stress disorder: An overview of what is used in research

Borghans¹,

Homberg²

2015

WJP

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Posttraumatic stress disorder (PTSD) is a common anxiety disorder characterised by its persistence of symptoms after a traumatic experience. Although some patients can be cured, many do not benefit enough from the psychological therapies or medication strategies used. Many researchers use animal models to learn more about the disorder and several models are available. The most-used physical stressor models are single-prolonged stress, restraint stress, foot shock, stress-enhanced fear learning, and underwater trauma. Common social stressors are housing instability, social instability, earlylife stress, and social defeat. Psychological models are not as diverse and rely on controlled exposure to the test animal's natural predator. While validation of these models has been resolved with replicated symptoms using analogous stressors, translating new findings to human patients remains essential for their impact on the field. Choosing a model to experiment with can be challenging; this overview of what is possible with individual models may aid in making a decision. Core tip: There are currently several widely accepted animal models being used in fundamental posttraumatic stress disorder (PTSD) research, and many publications using them have made valuable contributions to the collective knowledge on the subject. Still, the difference between models indicates that their suitability depends on the situation; each model has shown different amounts of success in replicating individual criteria or aspects of PTSD. Accordingly, the selection of the most suitable model for each experiment is important for optimally reliable results. This review offers relevant information to aid in that decision.Borghans B, Homberg JR. Animal models for posttraumatic REVIEW 387December 22, 2015|Volume 5|Issue 4|

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“…While the majority of neuroimaging investigations have focused on structural [4] and functional [5] aspects of PTSD, there is a growing body of literature regarding white matter integrity related to the disorder. Using diffusion-weighted magnetic resonance imaging (dMRI), researchers can use methods such as diffusion tensor imaging (DTI) and fiber tractography to estimate the density and directionality of neural and membrane integrity, using the proxy measures of fractional anisotropy (FA) and mean diffusivity [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder

Averill¹,

Averill²,

Wrocklage³

et al. 2018

Complex Psychiatry

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Purpose of the Study: Prior studies showed posttraumatic stress disorder (PTSD)-related alterations in white matter integrity, but most of these studies have used region-based approaches. We address this limitation by investigating the relationship between PTSD severity and fractional anisotropy (FA) using a tract-based approach. Procedures: Structural and diffusion magnetic resonance imaging were acquired from 67 combat-exposed US Veterans and processed using FSL/FreeSurfer TRActs Constrained by UnderLying Anatomy. Partial correlations were conducted between PTSD severity and FA of the cingulum and uncinate fasciculi covarying for age, sex, and head motion. Results: Only FA of the left cingulum angular bundle (CAB) was positively correlated with PTSD symptom severity (r = 0.433, p = 0.001, df = 57) and remained significant after Bonferroni correction. Conclusions: This finding may imply greater organization of the CAB with increasing PTSD severity. The CAB connects directly to the cingulate cortex and the hippocampal subiculum, critical nodes of the default mode network, as well as being implicated in neurodegeneration pathology, decision-making, and executive functions, which may help explain previously shown alterations in this network in PTSD. Message of the Paper: Further study of white matter tract integrity in PTSD is warranted, particularly to investigate whether the CAB connections with both higher-order cognitive functioning and emotion processing regions contribute to the pathophysiology and comorbidity of PTSD.

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A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder

Cited by 317 publications

References 203 publications

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

Animal models for posttraumatic stress disorder: An overview of what is used in research

Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder

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