A systematic review and meta-analysis of acupoint application combined with western medicine therapy in the treatment of bronchial asthma

Hu, Jun; Zhang, Cong; Zhao, Shumei; Ge, Kaiwen; Di, Kuan; Wang, Hesheng; Liu, Lanying

doi:10.21037/apm-21-2507

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Recently, a number of clinical studies have reported the effect of acupuncture on RD. Acupuncture enhanced the strength of diaphragm while relieving the respiratory muscle fatigue of COPD patients ( 9 ), mitigated overall symptoms of allergic rhinitis/rhinoconjunctivitis ( 10 ), and showed therapheutic effects on bronchial asthma as well ( 12 ). However, no studies oversee the RD animal studies and systematically analyzes the effect of acupuncture on inflammatory cytokine as its underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the latest studies using animal models of sepsis showed that electroacupuncture at ST36 modulates endotoxin-induced systemic inflammation through the vagal-adrenal anti-inflammatory axis ( 6 , 8 ). Recently, clinical research in COPD ( 9 ), allergic rhinitis ( 10 ), asthma ( 11 , 12 ) showed the possibility of acupuncture as a treatment for these pulmonary diseases. Moreover, there has been increasing evidence of potential therapeutic effects of acupuncture from research on the coronavirus disease 2019 ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Acupuncture on Modulating Inflammatory Cytokines in Rodent Animal Models of Respiratory Disease: A Systematic Review and Meta-Analysis

Lee

Kim²

2022

Front. Immunol.

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PurposeAlthough respiratory diseases (RD) are rapidly becoming a global health issue due to their high mortality and prevalence, there are limitations to the currently available treatments. Acupuncture has been recognized to mitigate many diseases by reducing inflammation and modulating cytokines. However, no systematic analysis has been performed to examine the effects of acupuncture on RD. We aimed to evaluate the effects of acupuncture on rodent animal models of RD.MethodsPubMed, EMBASE, MEDLINE, and the Research Information Service System were searched to retrieve studies that met our inclusion/exclusion criteria. The quality of each included study was evaluated using a 10-item checklist modified from the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies. With adequate data extracted, meta-analysis was performed using RevMan software.ResultsA total of 18 studies were included, and the mean quality assessment was 5.7. The meta-analysis revealed that acupuncture had a significant effect on changing the cytokine levels, including pro-/anti-inflammatory, Th1-, Th2- and Th17- specific cytokines.ConclusionAlthough there were limitations in the number of included studies, the results suggest that acupuncture can be a possible treatment for RD through its modulation of various cytokines, leading to reduced inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Acupuncture on Modulating Inflammatory Cytokines in Rodent Animal Models of Respiratory Disease: A Systematic Review and Meta-Analysis

Lee

Kim²

2022

Front. Immunol.

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Extraction process in Chuantieling (CTL) based on the quality by design (QbD) concept

Li²,

Guo³

2022

Digital Chinese Medicine

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[Retracted] Assessment of Acupoint Therapy of Traditional Chinese Medicine on Cough Variant Asthma: A Meta‐analysis

Zhang

2022

BioMed Research International

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Acupoint application has been used in China to treat various illnesses for ages. In cough variant asthma (CVA), the main clinical sign is episodic night cough. Acupoint application therapy of traditional Chinese medicine is an effective procedure to treat cough variant asthma. The current study is designed to systematically assess the effectiveness of acupoint application therapy in traditional medicine for patients with cough variant asthma. The comprehensive computer retrieval related to comparison between acupoint application and nonacupoint application therapy for cough variant asthma was carried out in various databases ( n = 8 ) from database establishment until July 4, 2021. Both English and Chinese articles about original investigations in humans were searched. Two independent authors extracted the data, and disagreements were resolved by discussion. ReviewManager 5.3 software provided by Cochrane did a meta-analysis of selected randomized controlled trials (RCTs). Quality of experimentation and risk bias were analyzed by the Cochrane Handbook tool. A total of thirteen randomized controlled clinical articles along with 1237 patients were included in the study. Findings of meta-analysis showed that compared with nonacupoint application treatment, the total effective rate of acupoint application treatment is more effective ( RD = 0.13 , 95% CI (0.09, 0.17), Z = 6.70 , P < 0.00001 ). Besides, acupoint application can improve patients’ lung function, the lung function index FVC ( mean difference = 0.55 , 95% confidence interval (0.42, 0.68), Z = 8.40 , P < 0.00001 ), FEV1 ( MD = 0.35 , 95% CI (0.23, 0.47), Z = 5.86 , P < 0.00001 ), FEV1/FVC (%) ( MD = 12.68 , 95% CI (4.32, 21.03), Z = 2.97 , P = 0.003 ), FEV1 (%) ( MD = 8.63 , 95% CI (8.01, 9.25), Z = 27.44 , P < 0.00001 ), and PEF (day) ( MD = 0.62 , 95% CI (0.52, 0.71), Z = 12.40 , P < 0.00001 ) of patients treated by acupoint application therapy were increased. Moreover, acupoint application might lower the level of immunoglobulin E ( MD = − 54.58 , 95% CI (−63.54, −45.61), Z = 11.93 , P < 0.00001 ) and EOS ( MD = − 0.21 , 95% CI (−0.35, −0.06), Z = 2.77 , P = 0.006 ). The LCQ (Leicester cough questionnaire) total score of CVA patients was also increased ( MD = 2.30 , 95% CI (1.55, 3.06), Z = 5.98 , P < 0.00001 ). Acupoint application therapy is effective in controlling symptoms of CVA. It also has a positive effect in improving lung function and life quality of patients. It can reduce the eosinophil levels and peripheral blood IgE levels of patients as well.

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A systematic review and meta-analysis of acupoint application combined with western medicine therapy in the treatment of bronchial asthma

Cited by 4 publications

References 19 publications

The Effect of Acupuncture on Modulating Inflammatory Cytokines in Rodent Animal Models of Respiratory Disease: A Systematic Review and Meta-Analysis

The Effect of Acupuncture on Modulating Inflammatory Cytokines in Rodent Animal Models of Respiratory Disease: A Systematic Review and Meta-Analysis

Extraction process in Chuantieling (CTL) based on the quality by design (QbD) concept

[Retracted] Assessment of Acupoint Therapy of Traditional Chinese Medicine on Cough Variant Asthma: A Meta‐analysis

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