A Systematic Review and Meta-Analysis of Buyang Huanwu Decoction in Animal Model of Focal Cerebral Ischemia

Wei, Rui-Li; Teng, Hai-Juan; Yin, Bin; Xu, Yang; Du, Yue; He, Fang-Pin; Chu, Ketan; Luo, Benyan; 鄭, 国慶

doi:10.1155/2013/138484

Cited by 48 publications

(47 citation statements)

References 28 publications

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“…Sensitivity analysis was performed by removing each study in sequence and recalculating the results, aiming to assess whether one or more studies influenced the overall results. We used funnel plots to examine asymmetry for publication bias, revealing an asymmetrical distribution of studies around the line of identity, indicating the possibility of a small indistinct study bias [27].…”

Section: Data Synthesis and Analysismentioning

confidence: 99%

Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis

Bachmann

Wang

et al. 2016

Deutsche Zeitschrift für Akupunktur

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Background. Sciatica is one of the most frequently reported complaints; it affects quality of life and reduces social and economic efficacy. Clinical studies on the efficacy of acupuncture therapy in sciatica are increasing, while systematic reviews assessing the efficacy of acupuncture therapy are still lacking. Objective. This study aims to assess the effectiveness of acupuncture therapy for sciatica. Methods. Comprehensive searches of 8 databases were conducted up until April 2015. Outcomes included effectiveness (proportion of patients who improved totally or partly in clinical symptoms), pain intensity, and pain threshold. Effect sizes were presented as risk ratio (RR) and mean difference (MD). Pooled effect sizes were calculated by fixed effects or random effects model. Results. A total of 12 studies (involving 1842 participants) were included. Results showed that acupuncture was more effective than conventional Western medicine (CWM) in outcomes effectiveness (RR 1.21, 95% CI: 1.16-1.25), pain intensity (MD −1.25, 95% CI: −1.63 to −0.86), and pain threshold (MD: 1.08, 95% CI: 0.98-1.17). Subgroup and sensitivity analysis found that the results did not change in different treatment method and drug categories substantially. The reported adverse effects were acceptable. Conclusions. Acupuncture may be effective in treating the pain associated with sciatica.

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Section: Data Synthesis and Analysismentioning

confidence: 99%

Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis

Bachmann

Wang

et al. 2016

Deutsche Zeitschrift für Akupunktur

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“…BYHWD is one of the classic formulas for post-stroke disability with intensive investigations. Several recent systematic reviews and meta-analysis studies conducted by us and others provide experimental and clinical evidence to support the application of BYHWD in the post-stroke treatments [67,68]. Although the quality of clinical trials needs to be improved, the effects of this formula on improving neurological functions have been well accepted.…”

Section: Classic Concepts and Representative Therapeutics For Stroke mentioning

confidence: 99%

Targeting Neurogenesis: A Promising Therapeutic Strategy for Post-Stroke Treatment with Chinese Herbal Medicine

Shen¹,

Chen²,

Chen³

et al. 2014

Integr Med Int

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Recent progress suggests that neural stem/progenitor cells can potentially develop into new functional neurons in adult brain, offering hope for regeneration therapies for stroke treatment. Targeting adult neurogenesis becomes a novel and promising therapeutic strategy for brain repair and recovery of neurological functions. Traditional Chinese Medicine (TCM) has a long history with accumulated experiences and case reports using herbal formulas to treat stroke disability. The combination of Chinese herbal medicine and stem cell biology approaches provides great potential for post-stroke rehabilitations. In the last decade, large efforts have been made to investigate the molecular targets for the regulation of adult neurogenesis and to explore the active compounds and molecular targets of herbal medicine for regeneration therapy. Herein, we reviewed the current progress concerning the molecular targets and cellular signaling pathways involved in adult neurogenesis after cerebral ischemia. We then briefly introduced Chinese medical theory and herbs for stroke treatment in TCM. Finally, we reviewed the current knowledge about the effects of Chinese herbal formulas, active fractions and active compounds on promoting adult neurogenesis as well as their molecular targets. Although the precise mechanisms and molecular targets of herbal medicine for neurogenesis are still unclear, current progress at least provides a cue for exploring the therapeutic principles of Chinese herbal medicine and developing new drugs for brain repair after stroke.

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“…Evidence-based investigations have found that BYHWD improves neurological deficiencies in both experimental studies and clinical trials [15-17]. Unfortunately, present reports tend to focus on a single target or pathway, and none of these studies has been able to reveal multifaceted regulatory mechanisms of BYHWD after ICH.…”

Section: Introductionmentioning

confidence: 99%

An Intersectional Study of LncRNAs and mRNAs Reveals the Potential Therapeutic Targets of Buyang Huanwu Decoction in Experimental Intracerebral Hemorrhage

Cui

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Both experimental and clinical studies have revealed satisfactory effects of the traditional Chinese formula Buyang Huanwu decoction (BYHWD) in improving post-intracerebral hemorrhage (ICH) neurological deficiencies. However, the multifaceted mechanisms of BYHWD in ICH treatment are not comprehensively understood. The present study explored various therapeutic targets of BYHWD by using lncRNA and mRNA transcriptomics. Methods: LncRNA and mRNA microarrays were used to identify differentially expressed genes. ICH-induced upregulated genes (ICH vs sham) and BYHWD-induced downregulated genes (BYHWD vs ICH) were first identified. The intersection between these 2 sets was determined to identify ICH-induced highly expressed genes that were reversed by BYHWD. Then, the genes downregulated after ICH and the genes upregulated after BYHWD treatment were used to generate another set of intersections. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were subsequently performed to determine relative biological functions and signaling transduction pathways according to genes within the intersections. Quantitative real-time PCR was used to validate changes in gene expression observed using the microarray. Finally, a lncRNA-mRNA co-expression network was established to identify links among the genes within the intersections. Results: A total of 18 differentially expressed lncRNAs and 33 differentially expressed mRNAs were identified using 2 lncRNA arrays (ICH vs sham and BYHWD vs ICH). The altered genes were enriched in the hemoglobin complex, oxygen transport and oxygen transporter and were closely associated with pyruvate metabolism. The co-expression network consisted of 53 nodes and 595 connections (308 positive interactions and 287 negative interactions). Conclusion: The hemoglobin complex, oxygen transport, oxygen transporter activity and pyruvate metabolism are possible therapeutic targets of BYHWD in ICH treatment. The present study provides the basis and direction for future investigations to explore the mechanisms by which BYHWD protects against long-term neurological deficiencies after ICH.

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A Systematic Review and Meta-Analysis of Buyang Huanwu Decoction in Animal Model of Focal Cerebral Ischemia

Cited by 48 publications

References 28 publications

Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis

Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis

Targeting Neurogenesis: A Promising Therapeutic Strategy for Post-Stroke Treatment with Chinese Herbal Medicine

An Intersectional Study of LncRNAs and mRNAs Reveals the Potential Therapeutic Targets of Buyang Huanwu Decoction in Experimental Intracerebral Hemorrhage

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