A systematic review and meta‐analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders

Abstract

Metabolic syndrome is characterized by multiple metabolic disorders. Several studies indicated that curcumin plus piperine could affect lipids profiles in various diseases.The present meta-analysis aims to assess the effect of curcumin plus piperine on lipid profiles in patients with MetS and associated disorders using a systematic review and meta-analysis of randomized controlled trials. Trials were searched by several electronic databases up to May 2022. The Comprehensive Meta-Analysis (CMA) version3 software carried out this systematic review and meta-analysis. Random-effects model and the inverse variance method were used to conduct the meta-analysis. We evaluated the publication bias and heterogeneity of all eligible studies. In addition, subgroup analyses and sensitivity assessments were performed to assess potential sources of heterogeneity. The combined results by the random-effects model demonstrated that curcumin plus piperine significantly decreased total cholesterol and LDL-C in patients suffering from metabolic syndrome. In comparison, the results of the overall effect size did not show any significant change in triglyceride concentrations. Our results were robust in sensitivity analysis and were not dependent on the dose of curcumin, the dose of piperine, and the duration of treatment. Our results showed that co-administration of piperine and curcumin supplementation improves the lipid profile in metabolic syndrome. However, further long-term RCTs are required to ascertain their clinical benefit.

The effects of Capsicum annuum supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials

“…These findings are generally in accordance with the results from previous meta‐analyses, which also identified a significant correlation between curcumin plus piperine supplementation and improvements in TC concentration in patients suffering from MetS (Hosseini et al, 2023). However, our results are not consistent with the previous meta‐analysis that reported a reduction in LDL‐C levels after supplementation with C. annuum (Jang et al, 2020).…”

Overview of Curcumin and Piperine Effects on Glucose Metabolism: The Case of an Insulinoma Patient’s Loss of Consciousness

“…Hoseini et al review (2023) [ 34 ] showed that the co-administration of curcumin and piperine, independently of the dose, in patients suffering from metabolic syndrome, can restore optimal blood lipid values, with a large reduction of total cholesterol and LDL, but no effect on TG levels.…”

Curcumin-Based Fixed Dose Combination Products for Cholesterol Management: A Narrative Review

“…From the previous section, there are many reasons why curcumin-based FDC products are attractive for cholesterol management. − Curcumin has been shown to inhibit key enzymes involved in the synthesis of cholesterol, such as HMG-CoA reductase. By reducing the activity of this enzyme, the production of cholesterol in the liver can be diminished.…”