A systematic review and meta-analysis on the efficacy and safety of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary liver cancer

Abstract

Background Transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) intervention in prolonging the long-term survival and prognosis of patients with liver cancer are still controversy compared with the traditional interventional therapy of RFA alone. This meta-analysis aimed to compare the efficacy and safety of combination therapy versus RFA alone. Methods The related articles were searched in PubMed, Embase, MEDLINE, Science Direct, The Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, Chinese Science and Technology Journal Database, and China Biomedical Literature Database (CBM). The Chinese and English search keywords included transcatheter arterial chemoembolization, TACE, radiofrequency ablation, RFA, primary liver cancer, and liver tumor. The five evaluation criteria of randomized controlled trials (RCTs) in Cochrane RoB 2.0 repeatedly independently evaluated the bias risks involved in the study and cross-checked the results. Results A total of 7 articles were included, and the results of bias risk assessment show that 6 articles described the generation of random sequences in detail; There were 3 articles describing allocation concealment in detail; Operator blindness was used in 4 articles; The outcome indicators of 7 documents were complete. The 3-year overall survival rate of the RFA combined with TACE group was significantly better than that of the RFA group [odds ratio (OR) =1.97, 95% confidence interval (CI): 1.42–2.74, Z=4.05, P<0.0001]. The 1-year and 3-year tumor recurrence-free survival rates in the RFA combined with TACE group were significantly better than those in the RFA group (OR =1.88, 95% CI: 1.28–2.76, Z=3.23, P=0.001; OR =2.11, 95% CI: 1.37–3.24, Z=3.38, P=0.0007). There was no significant difference in the complication rate of patients with primary liver cancer between the RFA combined with TACE group and the RFA group (OR =0.79, 95% CI: 0.45–1.39, Z=0.81, P=0.42). Discussion Meta-analysis results confirmed that TACE combined with RFA was safe and effective in the treatment of primary liver cancer, and can improve the overall survival and recurrence-free survival of patients with primary liver cancer.

Hug sign in intraprocedural cone-beam-CT to predict short-term response to combined treatment of hepatocellular carcinoma

“…In concordance with previous studies, our results confirm that combined therapy with thermal ablation followed by TACE is safe, with an overall response rate of 100% and a CR rate of 75% [24,25]. Univariate and multivariate analysis showed an association between residual tumor at first follow-up and lesion diameter and volume, as also demonstrated in previously published papers [26,27].…”

Chemoembolization combined radiofrequency ablation vs. chemoembolization alone for treatment of beyond the Milan criteria viable hepatocellular carcinoma (CERFA): study protocol for a randomized controlled trial

“…Recent studies on combination TACE and RFA therapy for early- and intermediate-stage HCC demonstrate promising results compared with TACE or RFA alone [ 4 , 6 , 7 , 15 – 17 ]. Theoretically, this combination therapy can overcome the limitations of each individual treatment.…”

“…Recent studies suggest that the combination of TACE and thermal ablation therapy is more effective than thermal ablation therapy alone [ 4 – 6 ]. However, these studies included patients with small (~ 3–5 cm), single tumours, whereas few studies have compared combination therapy versus TACE alone for intermediate-stage disease [ 7 ].…”

Threatment Strategies for Recurrent Hepatocellular Carcinoma Patients: Ablation and its Combination Patterns

“…2. effectively expand the area of coagulation necrosis and reduce the rate of LTP 68 . A meta-analysis found that TACE combined with RFA is a safe and effective treatment option for HCC, which significantly improves OS and RFS 69 .…”