A systematic review and meta-analysis for Chinese herbal medicine Duhuo Jisheng decoction in treatment of lumbar disc herniation

Abstract

Background: Lumbar disc herniation (LDH) is 1 of the most common diseases in orthopedics, which seriously affects people's daily life and brings a heavy burden on society and families. Chinese herbal medicine has been used in clinical practice for a long time and Duhuo Jisheng Decoction (DHJSD) is believed to help alleviate the symptoms of LDH. This systematic review aims to collect evidences from randomized clinical trials and evaluate the efficacy of DHJSD on LDH in order to provide a reference for clinicians and researchers. Methods: We will comprehensively search the 8 electronic databases until December 2019 to identify related randomized controlled trials, including 4 foreign databases (PubMed, MEDLINE, EMBASE, Cochrane Library) and 4 Chinese databases (China National Knowledge Infrastructure Database, VIP Database, Wanfang Database and China Biology Medicine disc). The data of the World Health Organization International Clinical Trial Registry Platform and the Chinese Clinical Trial Registry also will be searched. The primary outcomes are Japanese Orthopaedic Association scores and visual analog scale scores. The risk of bias will be assessed using the Cochrane Collaboration tool. RevMan (V.5.3) software will be used for meta-analysis. Results: This study will report the results of DHJSD for the treatment of LDH from the literature screening, the basic information of the included studies, the risk of bias of the included studies, treatment effects, safety, and so on. Conclusion: This systematic review will evaluate the effectiveness and safety of DHJSD for the treatment of LDH and provide the latest evidence for its clinical application. Ethics and dissemination: This is a literature-based study, therefore it does not require ethical approval. PROSPERO registration number: CRD42019147302.

Diagnosis Experience of Patients with Cervical, Thoracic and Lumbar Multi-Segment Spinal Stenosis: A Case Report and Literature Review

“…DHJSD has been widely used in the treatment of lumbar disc herniation [24] [25], and other orthopedic diseases, such as knee arthritis and osteoporosis [26] [27]. A systematic review and meta-analysis for DHJSD in the treatment of lumbar disc herniation also showed good effectiveness and safety [23]. In our case, after surgery, this patient was treated with DHJSD, with the dosage of 100 ml per day for three months.…”

“…This phenomenon is also an important factor that causes clinical misdiagnosis. [23]. DHJSD has been widely used in the treatment of lumbar disc herniation [24] [25], and other orthopedic diseases, such as knee arthritis and osteoporosis [26] [27].…”

Characteristics and mechanisms of resorption in lumbar disc herniation

“…Conservative treatment is the first choice for most newly diagnosed LDH patients. The conventional course of treatment is at least 6 weeks, and the main forms include bed rest, drug therapy, exercise therapy, epidural injection, lumbar traction, and traditional Chinese medicine treatment [2][3][4]. Most of the LDH symptoms can be relieved by conservative treatment.…”

Study on Anti-Inflammatory Mechanism of Angelica pubescens Based on Network Pharmacology and Molecular Docking

“…It is pungent in smell and bitter in taste, mild in nature, and medicinal in root. AP is one of the TCMs commonly used to treat ankylosing spondylitis, 6 knee osteoarthritis, 7 lumbar disc protrusion, 8 rheumatoid arthritis, 9 and other diseases, with significant clinical effects. At present, the 1 Tibet University Medical College, Lhasa, China 2 studies on AP are limited to the application of prescriptions such as Du Huo Jisheng Decotion, and there is no specific single drug report, and its pharmacological mechanism needs further excavation and analysis.…”