A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults

Abstract

The cluster of differentiation 36 (CD36) is one of the main receptors implicated in the pathogenesis of the cardiovascular disease. This study aimed to assess the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors including body mass index (BMI), waist circumference (WC), total cholesterol (TC), triglyceride, HDL-C, LDL-C, blood pressure and fasting blood glucose (FBG). PubMed, EMBASE, Scopus, web of science, and Google Scholar were searched up to December 2021. Subgroup and meta-regression analyses were conducted to explore sources of heterogeneity. Eighteen eligible studies (6317 participants) were included in the study. In the overall analysis, a significant association was found between rs1761667 polymorphism of CD36 and TG in allelic (p < 0.001), recessive (p = 0.001) and homozygous (p = 0.006) models. A relationship between this polymorphism and HDL-C and FBG level was observed in the recessive genetic model. In the subgroup analysis, the A allele was associated with impaired lipid profiles (TC, LDL-C and HDL-C) in the Asian population. The influences of health status, design of the study, confounders, and other sources of heterogeneity should be considered when interpreting present findings. Cohort studies with large sample size and in different ethnicities are needed to confirm the relationship between rs1761667 SNP and cardiometabolic risk factors.

The Interaction between <i>CD36</i> rs1761667 Polymorphism and Dietary Phytochemical Index on the Risk Factors Related to Metabolic Syndrome

“…In line with our results, a study on nondiabetic subjects reported no relationship between this polymorphism and the components of MetS in Caucasians [17]. This discrepancy in these results might be from several reasons, including different ethnicity, gene-environment and gene-gene interactions, clinical heterogeneity, and variation of the health status in different populations [18].…”

“…A meta-analysis of studies reported a significant association between rs1761667 and triglyceride (TG) (allelic, recessive, and homozygous models), HDL-C, and fasting blood glucose (FBG) level (recessive genetic model). Furthermore, it has been reported that the A allele was associated with higher HDL-C and lower total cholesterol and low-density lipoprotein cholesterol levels in Asians [18]. Furthermore, several research studies provided evidence regarding the relationship of this polymorphism with hypertension, dyslipidemia, obesity, metabolic syndrome, type 2 diabetes mellitus, consumption of total fat, and fat orosensory perception [19][20][21][22].…”

The cluster of differentiation 36 (CD36) rs1761667 polymorphism interacts with dietary patterns to affect cardiometabolic risk factors and metabolic syndrome risk in apparently healthy individuals

“…These discrepancies in findings might be due to the variations in the genotyping methods, ethnicity, health status, gene-environment or gene-gene interactions, and interactions of rs1761667 polymorphism with other variants in the CD36 gene. Another possible reason for these inconsistencies could be differences in the design of studies (20) .…”

“…Another possible reason for these inconsistencies could be differences in the design of studies (20) . Both deficiency and abnormally up-regulated CD36 lead to dyslipidaemia, metabolic disorders, inflammation and thrombosis (14) .…”

“…The evidence has shown the association of the A allele with a higher risk of stroke and type 2 diabetes mellitus (17)(18)(19) . Moreover, a meta-analysis study demonstrated that the A allele was related to elevated total cholesterol and LDLcholesterol and decreased HDL-cholesterol levels in Asians (20) . It was also found that the A allele was associated with higher BMI, WC, hip circumference, hypertension and coronary artery disease compared with the subjects with the GG genotype (21,22) .…”