A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress

Heshmati, Javad; Farsi, Farnaz; Shokri, Fatemeh; Rezaeinejad, Mahroo; Almasi‐Hashiani, Amir; Vesali, Samira; Sepidarkish, Mahdi

doi:10.1016/j.jff.2018.04.049

Cited by 58 publications

(39 citation statements)

References 50 publications

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“…Previous studies have shown that lactic acid bacteria, especially Lactobacillus spp. strains, possess antioxidant activity (Tonucci et al, 2017a;Heshmati et al, 2018). The intact cells, CFE, and CFS, of L. casei CCFM0412 and L. rhamnosus CCFM0528 were found to scavenge hydroxyl radicals and DPPH-free radicals, inhibit linoleic acid peroxidation in vitro, and enhance the antioxidative activities of mice in vivo (Chen et al, 2014b,c).…”

Section: Discussionmentioning

confidence: 99%

Screening for Potential Novel Probiotics With Dipeptidyl Peptidase IV-Inhibiting Activity for Type 2 Diabetes Attenuation in vitro and in vivo

Yan

Yue

et al. 2020

Front. Microbiol.

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Diabetes has become the second most severe disease to human health. Probiotics are important for maintaining gastrointestinal homeostasis and energy balance and have been demonstrated to play a positive role in the prevention and treatment of metabolic syndromes, such as obesity, inflammation, dyslipidemia, and hyperglycemia. The objective of this study was to screen potential antidiabetic strains in vitro and evaluate its effects in vivo. For the in vitro section, dipeptidyl peptidase IV (DPP-IV) inhibitory and antioxidant activities of 14 candidate Lactobacillus spp. strains were tested. Then hydrophobicity and acid and bile salt tolerance assays were determined. The most promising in vitro strain was further evaluated for its antidiabetic properties in vivo using type 2 diabetes mice induced by high-fat diet and intraperitoneal injection of streptozotocin (STZ). The reference strain for this study was Lactobacillus rhamnosus GG. Results showed that cell-free excretory supernatants and cell-free extracts of Lactobacillus acidophilus KLDS1.0901 had better DPP-IV inhibitory activity, antioxidative activities, and biological characteristics than other strains. At the end of the treatment, we found that L. acidophilus KLDS1.0901 administration decreased the levels of fasting blood glucose (FBG), glycosylated hemoglobin, insulin in serum and AUC glucose , and increased the level of glucagon-like peptide 1 in serum compared with diabetic mice (p < 0.05). Moreover, L. acidophilus KLDS1.0901 supplementation increased the activities of superoxide dismutase, glutathione peroxidase, the level of glutathione, and reduced the level of malondialdehyde in serum. These results indicated that L. acidophilus KLDS1.0901 could be used as a potential antidiabetic strain; its application as food supplement and drug ingredient is thus recommended.

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Section: Discussionmentioning

confidence: 99%

Screening for Potential Novel Probiotics With Dipeptidyl Peptidase IV-Inhibiting Activity for Type 2 Diabetes Attenuation in vitro and in vivo

Yan

Yue

et al. 2020

Front. Microbiol.

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“…Moreover, the levels of MDA were significantly decreased. 42 It is suggested that synbiotics can improve the composition of gut microflora and reduce oxidative stress by changing the composition of microflora and reducing LPS concentration. Recently, it has been shown that intestinal bacteria (probiotics) can reduce the production of NF-κB, which can interfere with the transcription of a large number of inflammatory genes and decrease oxidative stress.…”

Section: Synbiotic and Periodontal Indicesmentioning

confidence: 99%

<p>The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial</p>

Bazyar¹,

Maghsoumi‐Norouzabad²,

Yarahmadi³

et al. 2020

DMSO

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The aim of the current study was to investigate that combination of the synbiotic supplementation in adjunct with non-surgical periodontal therapy (NSPT) is useful in treating periodontitis and biomarkers of oxidative stress in type 2 diabetes mellitus (T2DM) patients. Methods: In this study, 47 patients suffering from DM and CP were recruited and randomly assigned to two groups. The intervention (n= 23) and control (n=24) groups received either multispecies probiotic supplement plus 100 mg fructo-oligosaccharide (500 mg in each capsule) or placebo capsule containing 500 mg wheat flour, respectively, every day for 8 weeks. All subjects were treated with NSPT during the intervention period. Serum levels of interleukin-1β (IL-1β), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and periodontal indices including clinical attachment loss (CAL), pocket depth (PD) (main outcome), BOP, and plaque index were measured before and after the intervention. Results: Supplementation with the synbiotic with NSPT led to a significant decrease in the levels of IL-1β, MDA, plaque index, PD, and CAL in the intervention group post-intervention (p < 0.05). The serum levels of TAC, SOD, and GPx were significantly increased in the intervention group compared with the baseline (p < 0.05). Consumption of synbiotic with NSPT, compared to the control, resulted in a significant decrease in the mean changes of IL-1β, MDA, and CAL (p < 0.05). Also, the mean changes of TAC and GPx were significantly higher in the intervention group compared with the control group (p < 0.05). Also, in the intervention group was seen a significant reduction in plaque index (p = 0.035) and BOP (p = 0.04) compared with the control group. Conclusion: It was observed that synbiotic supplementation with NSPT may be beneficial in improving inflammatory, antioxidant, and periodontal status in T2DM patients with CP.

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“…As previously reported, Cu/Zn‐SOD and Mn‐SOD were the main antioxidant gatekeepers that could scavenge superoxide anion (Wouters et al, ), while activation of Cu/Zn‐SOD decreased oxidative stress‐induced hepatic collagen and damage (Ye, Jia, Tang, & Chen, ). Since butyrate can provide nicotinamide adenine dinucleotide phosphate (NADPH) for the formation of GSH, probiotics also enhanced antioxidant capacities by producing butyrate (Heshmati et al, ). Table summarizes antioxidant effects of other probiotic strains.…”

Section: Antioxidative Activity Of Probioticsmentioning

confidence: 99%

Health promoting activities of probiotics

Tang

2019

J Food Biochem

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In recent years, probiotics have received increasing attention and become one type of popular functional food because of their many biological functions. Among these desirable biological functions, the immune regulation, antioxidative activities, and antimicrobial effects are essential properties to maintain host health. Probiotics can regulate the immune system and improve the antioxidative system by producing microbial components and metabolites. Meanwhile, probiotics also possess antimicrobial abilities owing to their competition for nutrient requirements and mucus adherence, reducing pathogenic toxins, producing antimicrobial metabolites (short‐chain fatty acids, bacteriocins, reuterin, linoleic acid, and secondary bile acids) and enhancing intestinal, or systemic immunity. Therefore, probiotics could be used to alleviate heavy metal toxicity and metabolic disorders by improving immunity, the antioxidative system, and intestinal micro‐environment. This comprehensive review mainly highlights the potential health promoting activities of probiotics based on their antioxidative, antimicrobial, and immune regulatory effects. Practical applications The antioxidative defense and the immune system are essential to maintain human health. However, many factors may result in microbial dysbiosis in the gut, which subsequently leads to pathogenic expansion, oxidative stress, and inflammatory responses. Therefore, it is important to explore beneficial foods to prevent or suppress these abnormal responses. Successful application of probiotics in the functional foods has attracted increasing attention due to their immune regulatory, antioxidative, and antimicrobial properties. The aim of this review is to introduce immune regulatory antioxidative and antimicrobial effects of probiotics, which provides some basic theories for scientific research and development of potential functional foods.

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A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress

Cited by 58 publications

References 50 publications

Screening for Potential Novel Probiotics With Dipeptidyl Peptidase IV-Inhibiting Activity for Type 2 Diabetes Attenuation in vitro and in vivo

Screening for Potential Novel Probiotics With Dipeptidyl Peptidase IV-Inhibiting Activity for Type 2 Diabetes Attenuation in vitro and in vivo

<p>The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial</p>

Health promoting activities of probiotics

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