A systematic review and meta-analysis of occupational exposures and risk of follicular lymphoma

Odutola, Michael; Benke, Geza; Fritschi, Lin; Giles, Graham G.; Leeuwen, Marina T. van; Vajdic, Claire M.

doi:10.1016/j.envres.2021.110887

Cited by 12 publications

(13 citation statements)

References 109 publications

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“…Initially, we detected many reviews on various facets of the pesticides and cancer topic that were potentially relevant. 24,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] Of them, some [41][42][43][44][45][46][47][48][49][50]60,61 are particularly relevant to complement our analysis and address issues that it is unnecessary to repeat in the present paper.…”

Section: Methodsmentioning

confidence: 99%

“…We included cohort, case‐control, case‐cohort and survival studies 40 assessing the relationship between pesticide exposure and cancer incidence, prevalence, survival and markers of severity in humans. Initially, we detected many reviews on various facets of the pesticides and cancer topic that were potentially relevant 24,41‐59 . Of them, some 41‐50,60,61 are particularly relevant to complement our analysis and address issues that it is unnecessary to repeat in the present paper.…”

Section: Methodsmentioning

confidence: 99%

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Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia (AML) and colorectal cancer (CRC), diseases in which the observed associations were consistent across several studies, including high‐quality prospective studies and those using biomarkers for exposure assessment, with some observing dose‐response relationships. Though high‐quality studies have been published since the IARC monograph on organophosphate insecticides in 2017, there are still gaps in the literature on carcinogenic evidence in humans for a large number of pesticides. To further knowledge, we suggest leveraging new techniques and methods to increase sensitivity and precision of exposure assessment, incorporate multi‐omics data, and investigate more thoroughly exposure to chemical mixtures. There is also a strong need for better and larger population‐based cohort studies that include younger and nonoccupationally exposed individuals, particularly during developmental periods of susceptibility. Though the existing evidence has limitations, as always in science, there is sufficient evidence to implement policies and regulatory action that limit pesticide exposure in humans and, hence, further prevent a significant burden of cancers.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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“…Results from a Swedish study that measured OCP concentrations in six food groups (fish, meat, dairy products, egg, fats/oils, and pastries) showed higher levels of dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyltrichloroethane (DDT) in fish compared to the other food groups ( 7 ), similar to findings from Australian ( 6 ) and US ( 8 ) studies that examined OCPs in nine food groups and 31 food types, respectively. Furthermore, findings from occupational studies showed an elevated FL risk with organochlorine pesticide exposure ( 45 – 47 ), while meta-analyses of observational studies showed a positive association between plasma organochlorine DDE ( 5 ) and self-reported DDT ( 48 ) exposure, and FL risk.…”

Section: Discussionmentioning

confidence: 99%

“…FL is most common in middle-aged and elderly individuals, with a median age at diagnosis of 61 years (2). The etiology of FL is not fully understood but risk increases with age, family history, smoking and pesticide exposure (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Dietary intake of animal-based products and likelihood of follicular lymphoma and survival: A population-based family case-control study

Odutola

Leeuwen²,

Bassett³

et al. 2023

Front. Nutr.

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BackgroundThe association between dietary intake of foods of animal origin and follicular lymphoma (FL) risk and survival is uncertain. In this study, we examined the relationship between dietary intake of dairy foods and fats, meat, fish and seafoods, and the likelihood of FL and survival.MethodsWe conducted a population-based family case-control study in Australia between 2011 and 2016 and included 710 cases, 303 siblings and 186 spouse/partner controls. We assessed dietary intake of animal products prior to diagnosis (the year before last) using a structured food frequency questionnaire and followed-up cases over a median of 6.9 years using record linkage to national death data. We examined associations with the likelihood of FL using logistic regression and used Cox regression to assess association with all-cause and FL-specific mortality among cases.ResultsWe observed an increased likelihood of FL with increasing daily quantity of oily fish consumption in the year before last (highest category OR = 1.96, CI = 1.02–3.77; p-trend 0.06) among cases and sibling controls, but no associations with spouse/partner controls. We found no association between the likelihood of FL and the consumption of other types of fish or seafood, meats or dairy foods and fats. In FL cases, we found no association between meat or oily fish intake and all-cause or FL-specific mortality.ConclusionOur study showed suggestive evidence of a positive association between oily fish intake and the likelihood of FL, but findings varied by control type. Further investigation of the potential role of environmental contaminants in oily fish on FL etiology is warranted.

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“…Interestingly, however, these have shown no association overall between p,pʹ -DDE or p,pʹ -DDT concentration in blood or adipose tissue and breast cancer risk [ 14 ]. For other cancer sites, positive associations have been suggested for liver and testicular cancer and non-Hodgkin lymphoma [ 15 , 16 ]. IARC evaluated the evidence regarding the carcinogenicity of DDT in humans as limited [ 8 , 17 ] but, considered together with sufficient evidence for the carcinogenicity of DDT in experimental animals, gave an overall evaluation of probably carcinogenic to humans (Group 2A) in 2015 (Table 1 ) [ 8 , 17 ].…”

Section: Organochlorine Pesticidesmentioning

confidence: 99%

Exposure to environmental chemicals and cancer risk: epidemiological evidence from Japanese studies

Iwasaki¹,

Itoh

Sawada³

et al. 2023

Genes and Environ

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Exposure to certain chemicals in the environment may contribute to the risk of developing cancer. Although cancer risk from environmental chemical exposure among general populations is considered low compared to that in occupational settings, many people may nevertheless be chronically exposed to relatively low levels of environmental chemicals which vary by such various factors as residential area, lifestyle, and dietary habits. It is therefore necessary to assess population-specific exposure levels and examine their association with cancer risk. Here, we reviewed epidemiological evidence on cancer risk and exposure to dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFASs), cadmium, arsenic, and acrylamide. Japanese are widely exposed to these chemicals, mainly through the diet, and an association with increased cancer risk is suspected. Epidemiological evidence from Japanese studies to date does not support a positive association between blood concentrations of DDT, HCH, PCBs, and PFASs and risk of breast or prostate cancer. We established assessment methods for dietary intake of cadmium, arsenic, and acrylamide using a food frequency questionnaire. Overall, dietary intakes of cadmium, arsenic, and acrylamide were not significantly associated with increased risk of total cancer and major cancer sites in the Japan Public Health Center-based Prospective Study. However, statistically significant positive associations were observed between dietary cadmium intake and risk of estrogen receptor-positive breast cancer among postmenopausal women, and dietary arsenic intake and risk of lung cancer among male smokers. In addition, studies using biomarkers as exposure assessment revealed statistically significant positive associations between urinary cadmium concentration and risk of breast cancer, and between ratio of hemoglobin adducts of acrylamide and glycidamide and risk of breast cancer. Epidemiological studies of general populations in Japan are limited and further evidence is required. In particular, studies of the association of organochlorine and organofluorine compounds with risk of cancer sites other than breast and prostate cancer are warranted, as are large prospective studies of the association between biomarkers of exposure and risk of cancer.

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A systematic review and meta-analysis of occupational exposures and risk of follicular lymphoma

Cited by 12 publications

References 109 publications

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Dietary intake of animal-based products and likelihood of follicular lymphoma and survival: A population-based family case-control study

Exposure to environmental chemicals and cancer risk: epidemiological evidence from Japanese studies

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