A Systematic Review and Meta-Analysis on the Efficacy and Safety of Direct Oral Anticoagulants in Patients with Peripheral Artery Disease

Peppas, Spyros; Sagris, Μarios; Bikakis, Iosif; Giannopoulos, Stefanos; Tzoumas, Andreas; Kokkinidis, Damianos G.; Ahmed, Zain; Korosoglou, Grigorios; Malgor, Emily A.; Malgor, Rafael D.

doi:10.1016/j.avsg.2021.07.028

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…In this context, reports of cardiac arrhythmias have been made. As a result of myocardial inflammation and potential extensive necrosis, re-entry points in the electrical circuit may occur, leading to ventricular tachycardia and ventricular fibrillation [ 12 , 13 , 14 ]. Troponin levels have been associated with the worst outcomes, while other independent factors such as higher levels of leukocytes, D-dimer, CRP, ferritin, and IL-6 have been recognized in patients with severe COVID-19 disease.…”

Section: Inflammatory Mechanisms In Covid-19-related Cardiovascular D...mentioning

confidence: 99%

Genetic Predisposition and Inflammatory Inhibitors in COVID-19: Where Do We Stand?

et al. 2022

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Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and the resulting coronavirus disease-19 (COVID-19) have led to a global pandemic associated with high fatality rates. COVID-19 primarily manifests in the respiratory system as an acute respiratory distress syndrome following viral entry through the angiotensin-converting enzyme-2 (ACE2) that is present in pulmonary epithelial cells. Central in COVID-19 is the burst of cytokines, known as a “cytokine storm”, and the subsequent widespread endothelial activation, leading to cardiovascular complications such as myocarditis, arrhythmias, and adverse vascular events, among others. Genetic alterations may play an additive, detrimental role in the clinical course of patients with COVID-19, since gene alterations concerning ACE2, major histocompatibility complex class I, and toll-like receptors may predispose patients to a worse clinical outcome. Since the role of inflammation is quintessential in COVID-19, pharmacologic inhibition of various signaling pathways such as the interleukin-1 and -6, tumor necrosis factor-alpha, interferon gamma, Janus kinase-signal transducer and activator of transcription, and granulocyte–macrophage colony-stimulating factor may ameliorate the prognosis following timely administration. Finally, frequently used, non-specific anti-inflammatory agents such as corticosteroids, statins, colchicine, and macrolides represent additional therapeutic considerations.

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Section: Inflammatory Mechanisms In Covid-19-related Cardiovascular D...mentioning

confidence: 99%

Genetic Predisposition and Inflammatory Inhibitors in COVID-19: Where Do We Stand?

et al. 2022

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“…As a result, and according to the latest guidelines for the management of AF [7,13,14,16,50,51], dabigatran is not recommended in ESKD patients with AF. However, due to the lack of sufficient data, the clinician can tailor his decision, taking into consideration the existing data and the patient's profile [52].…”

Section: Dabigatranmentioning

confidence: 99%

Direct Oral Anticoagulants in Patients on Chronic Dialysis and Concomitant Atrial Fibrillation: A Common Clinical Impasse

Ktenopoulos¹,

Sagris²,

Theofilis³

et al. 2022

Front. Biosci. (Schol Ed)

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The most frequent arrhythmia treated is atrial fibrillation (AF), which necessitates the use of oral anticoagulants (OACs) to reduce the risk of thromboembolism and stroke. Patients with chronic kidney disease are more likely to develop AF, with a 10% frequency among those on chronic dialysis. Warfarin is the most widely prescribed OAC for individuals with end-stage kidney disease (ESKD). On the other hand, direct OACs (DOACs) are generally safer than warfarin, with fewer fatal bleeding events and a fixed dose that does not require close international normalized ratio (INR) monitoring. For those patients, warfarin and apixaban appear to be FDA-approved, whereas dabigatran, rivaroxaban, and edoxaban are not recommended yet. Due to a lack of large randomized studies, data from major trials cannot be extended to dialysis patients. In this review, we summarize the available data and literature referring to patients on chronic hemodialysis with concomitant AF. Due to the scarcity of data, we try to assist clinicians in selecting the appropriate therapy according to the specific characteristics of each patient. Finally, future directions are provided in two key areas of focus: left atrial appendage closure therapies and genetic research.

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“…It has been found that using Chinese herbal medicine to address intestinal microbiota abnormalities in the body is useful in the prevention and treatment of T2DM ( 8 ). Astragali Radix is a Chinese plant originated in Northern China that first appears in the Shennong Ben Cao Jing ( 9 ) and serves as one of the most commonly used single herbs in hypoglycemic herbal medicine. In traditional Chinese medicine (TCM), Astragali Radix can be paired with other herbs, such as ginseng and atractylodes, to participate in the composition of a variety of Chinese medicine compound.…”

Section: Introductionmentioning

confidence: 99%

Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review

Su,

Tang,

Tang

et al. 2023

Front. Immunol.

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Diabetes is a significant chronic endocrine/metabolism disorder that can result in a number of life-threatening consequences. According to research, the gut microbiota is strongly linked to the development of diabetes, making it a viable target for diabetes treatment. The intestinal microbiota affects intestinal barrier function, organism immunity, and thus glucose metabolism and lipid metabolism. According to research, a disruption in the intestinal microbiota causes a decrease in short-chain fatty acids (SCFAs), alters the metabolism of bile acids (BAs), branched-chain amino acids (BCAAs), lipopolysaccharide (LPS), and endotoxin secretion, resulting in insulin resistance, chronic inflammation, and the progression to type 2 diabetes mellitus (T2DM). Astragali Radix is a medicinal herb of the same genus as food that has been extensively researched for treating diabetes mellitus with promising results in recent years. Polysaccharides, saponins, flavonoids, and other components are important. Among them, Astragaloside has a role in protecting the cellular integrity of the pancreas and liver, can leading to alleviation of insulin resistance and reducing blood glucose and triglyceride (TC) levels; The primary impact of Astragalus polysaccharides (APS) on diabetes is a decrease in insulin resistance, encouragement of islet cell proliferation, and suppression of islet β cell death; Astragali Radix flavonoids are known to enhance immunity, anti-inflammatory, regulate glucose metabolism and control the progression of diabetes. This study summarizes recent studies on Astragali Radix and its group formulations in the treatment of type 2 diabetes mellitus by modulating the intestinal microbiota.

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A Systematic Review and Meta-Analysis on the Efficacy and Safety of Direct Oral Anticoagulants in Patients with Peripheral Artery Disease

Cited by 7 publications

References 31 publications

Genetic Predisposition and Inflammatory Inhibitors in COVID-19: Where Do We Stand?

Genetic Predisposition and Inflammatory Inhibitors in COVID-19: Where Do We Stand?

Direct Oral Anticoagulants in Patients on Chronic Dialysis and Concomitant Atrial Fibrillation: A Common Clinical Impasse

Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review

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