A systematic review identifying seminal plasma biomarkers and their predictive ability on IVF and ICSI outcomes

van den Berg, Jonna S.; Molina, Nerea M.; Altmäe, Signe; Arends, Brigitte; Steba, Gaby Sarina

doi:10.1016/j.rbmo.2023.103622

Cited by 2 publications

(4 citation statements)

References 125 publications

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“…Research has focused on exploring the connection between IVF fertilization rates and SP cytokines. The group that achieved pregnancy showed a greater transforming growth factor beta 1 (TGF-β1) to interleukin 18 (IL-18) ratio (TGF-β1/IL-18), despite having much lower pro-inflammatory IL-18 levels compared to those who did not conceive [10] Αccording to research by Seshadri et al (2011), there were no significant differences in SP sHLΑ-G concentrations between men whose partners became pregnant and those whose partners did not. Nevertheless, men with a high fertilization rate (≥60%) appeared to have significantly higher levels of SP IL-11 compared to males with a low rate of fertilization (<35%) [11].…”

Section: Seminal Plasma's Immunological Apparatusmentioning

confidence: 99%

“…Five research studies have identified 25 putative biomarkers for ART outcomes. While two studies found no significant link between lead (Pb) and IVF fertilization rate, four studies found a negative correlation [ 10 ]. A thorough analysis of many metals and trace elements in SP was conducted by Rodríguez-Díaz et al in 2022.…”

Section: Metals Trace Elements and Nucleic Acidsmentioning

confidence: 99%

“…Seminal plasma biomarkers have the potential to enable long-term tracking of disease development or recurrence. They may also be more cost-effective than some current diagnostic techniques [ 10 ]. They are easily collected and transferred for processing, even in resource-constrained contexts, and can yield helpful diagnostic data.…”

Section: Male Infertility and Seminal Plasma Indicatorsmentioning

confidence: 99%

“…Soluble CD14 (sCD14-ST) levels increased during inflammation, but no correlation was found between them and the outcome of IVF or ICSI. Higher quantities of SP protein were found in men with high rates of fertilization and fertility [ 10 ].…”

Section: Transcriptomics Proteomics Metabolomicsmentioning

confidence: 99%

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Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice

Moustakli,

Zikopoulos,

Skentou

et al. 2024

JCM

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Infertility represents a significant global health challenge impacting millions of couples worldwide. Approximately half of all infertile couples exhibit compromised semen quality, indicative of diminished male fertility. While the diagnosis of male infertility traditionally relies on semen analysis, its limitations in providing a comprehensive assessment of male reproductive health have spurred efforts to identify novel biomarkers. Seminal plasma, a complex fluid containing proteins, lipids, and metabolites, has emerged as a rich source of such indicators. Reproduction depends heavily on seminal plasma, the primary transporter of chemicals from male reproductive glands. It provides a non-invasive sample for urogenital diagnostics and has demonstrated potential in the identification of biomarkers linked to illnesses of the male reproductive system. Τhe abundance of seminal proteins has enabled a deeper understanding of their biological functions, origins, and differential expression in various conditions associated with male infertility, including azoospermia, asthenozoospermia, oligozoospermia, teratozoospermia, among others. The true prevalence of male infertility is understated due to the limitations of the current diagnostic techniques. Τhis review critically evaluates the current landscape of seminal plasma biomarkers and their utility in assessing male infertility. Βy bridging the gap between research and clinical practice, the integrative assessment of seminal plasma biomarkers offers a multimodal approach to comprehensively evaluate male infertility.

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Section: Seminal Plasma's Immunological Apparatusmentioning

confidence: 99%

Section: Metals Trace Elements and Nucleic Acidsmentioning

confidence: 99%

Section: Male Infertility and Seminal Plasma Indicatorsmentioning

confidence: 99%

Section: Transcriptomics Proteomics Metabolomicsmentioning

confidence: 99%

See 2 more Smart Citations

Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice

Moustakli,

Zikopoulos,

Skentou

et al. 2024

JCM

View full text Add to dashboard Cite

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COVID‐19 and Oncofertility: No SARS‐CoV‐2 in Semen but Inflammation Seems to Affect Sperm Parameters

Chaput,

Pons‐Rejraji,

Chabrolles

et al. 2024

Journal of Medical Virology

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The COVID‐19 pandemic, driven by SARS‐CoV‐2, led authorities to recommend halting assisted reproductive technology programs, focusing instead on fertility preservation, for cancer patients. The presence of SARS‐CoV‐2 in semen remains controversial. This multicentric prospective cohort study, conducted across 12 university medical centers, aimed to determine if SARS‐CoV‐2 is present in spermatozoa/seminal plasma in cancer patients by RT‐PCR and to assess its impact on standard semen parameters. The levels of cytokines and TNF‐α were measured in seminal fluid by ELISA. We enrolled 129 men who underwent sperm cryopreservation between July 7, 2020, and June 30, 2021. The 63 were included and tested for COVID‐19 in nasal swab samples by RT‐PCR and/or by serology. All patients were asymptomatic on the day of semen collection: 50 were uninfected, 8 had a positive nasal swab (PCR+) and 5 were seropositive. SARS‐CoV‐2 RNA was not detected in the seminal fluid or spermatozoa. Ejaculate volume was significantly lower in the PCR+ group compared to the uninfected group (median [IQR]: 2.6 mL [1.6–3.4] vs. 4.6 mL [2.6–5.2] p < 0.05). Total and progressive motility were lower in the PCR+ group compared to the seropositive group (32.5% [25.0–45.0] vs. 50% [49.0–55.0] p < 0.05, and 22.5% [10.0; 32.5] vs. 44.5% [40–49] p < 0.05). Higher TNF‐α level was observed in the PCR+ group (1.9 pg/mL [0–3.9]) compared to the uninfected group (0 pg/mL [0–0.4]) p < 0.05. Although SARS‐CoV‐2 was not detected in the sperm samples of cancer patients who were PCR+, the infection appears to impact sperm parameters, likely due to inflammation.

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A systematic review identifying seminal plasma biomarkers and their predictive ability on IVF and ICSI outcomes

Cited by 2 publications

References 125 publications

Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice

Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice

COVID‐19 and Oncofertility: No SARS‐CoV‐2 in Semen but Inflammation Seems to Affect Sperm Parameters

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