2022
DOI: 10.1101/cshperspect.a041304
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A Systematic Review of Optogenetic Vision Restoration: History, Challenges, and New Inventions from Bench to Bedside

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Cited by 5 publications
(5 citation statements)
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“…Amongst optical neuromodulation methods, optogenetics has received considerable attention recently ( Klapper et al, 2016 ; Bar-Noam and Shoham, 2020 ; Lindner et al, 2022 ; Sakai et al, 2022 ; Parnami and Bhattacharyya, 2023 ; Stefanov and Flannery, 2023 ). Apart from photoreceptors, most mammalian neurons are not inherently sensitive to light.…”
Section: Less Invasive Neuromodulation Strategiesmentioning
confidence: 99%
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“…Amongst optical neuromodulation methods, optogenetics has received considerable attention recently ( Klapper et al, 2016 ; Bar-Noam and Shoham, 2020 ; Lindner et al, 2022 ; Sakai et al, 2022 ; Parnami and Bhattacharyya, 2023 ; Stefanov and Flannery, 2023 ). Apart from photoreceptors, most mammalian neurons are not inherently sensitive to light.…”
Section: Less Invasive Neuromodulation Strategiesmentioning
confidence: 99%
“…Further progress is needed to restore vision to a level that offers the space and time resolution necessary for basic daily tasks. This requires optimization of optogenetic tools and protocols for their safe and reliable delivery at appropriate levels to the most appropriate cell types and cellular sites ( Simunovic et al, 2019 ; Lindner et al, 2022 ; Stefanov and Flannery, 2023 ). For example, it has been shown that antagonistic center-surround receptive field interactions can be mimicked by localizing a hyperpolarizing opsin to the dendritic tips and a depolarizing channel to the soma ( Greenberg et al, 2011 ; Wu et al, 2013 ).…”
Section: Less Invasive Neuromodulation Strategiesmentioning
confidence: 99%
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“…retinoschisis (Ku et al 2022), nAMD, and some approaches for optogenetic therapy (Roska 2022;Stefanov and Flannery 2022).…”
Section: Route Of Administrationmentioning
confidence: 99%
“…For diseases that have advanced so far that gene augmentation would not be effective (i.e., the primary cell type has degenerated and thus cannot be treated with gene therapy), it may be necessary to render other second-or thirdorder retinal neurons light-sensitive. These approaches are described by Roska (2022) and Stefanov Flannery (2022), respectively.…”
Section: Gene-agnostic Approachesmentioning
confidence: 99%