A systematic review of the psychosocial impact of fibroids before and after treatment

Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

“…In contrast, CCH injection at low dose (0.05 mg/cm 3 ) increased stiffness by 22% ( p = 0.630) (b). Of note, stiffness of fibroid tissue was significantly reduced (46%) by CCH injection at the two highest doses (0.1–0.2 mg/cm 3 ) ( p = 0.031) (c). Data are presented as means ± SEM of CCH‐treated or control fibroids (these are considered as biological replicates).…”

“…Women with fibroids consider the impact of the disease on their life similar to a diagnosis of diabetes, heart disease, or breast cancer. 3 Many women with symptomatic uterine fibroids require medical or surgical interventions. Medical treatments for fibroids remain limited.…”

“…Surgical treatments are associated with risks and negatively impact on women's quality of life. 3 Furthermore, the annual cost associated with fibroid management is estimated to be between $5.9 and $34.4 billion (2010 USD) in the United States. 11 Therefore, there is a pressing need for nonsurgical treatment alternatives.…”

“…Clinical symptoms occur in 20%–50% of women with fibroids 1,2 making fibroid disease among the most frequently encountered health conditions of women. Women with fibroids consider the impact of the disease on their life similar to a diagnosis of diabetes, heart disease, or breast cancer 3 . Many women with symptomatic uterine fibroids require medical or surgical interventions.…”

“…The use of ulipristal acetate for uterine fibroid treatment in the United States remains uncertain. Surgical treatments are associated with risks and negatively impact on women's quality of life 3 . Furthermore, the annual cost associated with fibroid management is estimated to be between $5.9 and $34.4 billion (2010 USD) in the United States 11 .…”