A Systematic Review on Antimicrobial and Antiparasitic Activity of Eurycoma longifolia Jack (Tongkat Ali)

Latip, Mohd Qayyum Ab; Noor, Mohd Hezmee Mohd; Ahmad, Hafandi; Hassim, Hasliza Abu; Salleh, Annas; Bejo, Mohd Hair; Zakaria, Alif Aiman

doi:10.1155/2022/4999797

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Physiologically, it is a tall, slender, flowering shrub which grows up to 10 m in sandy soil 6 7. This herb is known for its antipyretic, antimalarial, antibacterial, antidiabetic properties since ancient times due to the presence of numerous bioactive compounds such as alkaloids, quassinoids, peptides, eurycolactone and eurycomalactone in the plant’s roots 8. Furthermore, regular intake of EL as dietary supplement has proven to alleviate stress, eases tension, enhances physical performances, restores energy and stamina which directly improve the overall quality of life 9.…”

Section: Introductionmentioning

confidence: 99%

“… 6 7 This herb is known for its antipyretic, antimalarial, antibacterial, antidiabetic properties since ancient times due to the presence of numerous bioactive compounds such as alkaloids, quassinoids, peptides, eurycolactone and eurycomalactone in the plant’s roots. 8 Furthermore, regular intake of EL as dietary supplement has proven to alleviate stress, eases tension, enhances physical performances, restores energy and stamina which directly improve the overall quality of life. 9 Locally recognised as ‘Tongkat Ali’ in Malaysia, its roots are boiled traditionally to prepare energy decoctions which predominantly used to treat impotency and decreased virility among men.…”

Section: Introductionmentioning

confidence: 99%

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Effects ofEurycoma longifolia Jackstandardised water extract (Physta) on well-being of perimenopausal and postmenopausal women: protocol for a randomised, double-blinded, placebo-controlled, parallel group study

Muniandy,

Yahya,

Shahar

et al. 2023

BMJ Open

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IntroductionEurycoma longifolia Jack(EL), profoundly recognised as ‘Tongkat Ali’, is a medicinal herb originating from Southeast Asia. It is commonly used in traditional ‘antiageing’ treatments to address decreased energy, mood, libido and hormonal imbalances. While the benefits of EL have been extensively studied among the male population, less attention has been given to its effects on women. Menopause can impact the overall well-being of middle-aged women and incorporation of herbal supplements can aid them in managing the menopausal symptoms.Methods and analysisThis 12-week randomised double-blind, placebo-controlled, parallel-group study aims to evaluate the efficacy of the standardised water extract of EL known as Physta in increasing the quality of life of perimenopausal and postmenopausal women. The study involves 150 women aged 40–55 years who score more than 61 on the Menopause-Specific Quality of Life (MENQOL) assessment. These participants will be randomised into three groups, receiving Physta at either 50 mg or 100 mg or a placebo. The outcomes measures include mood state, quality of life, fatigue, sleep quality, sexual function and pain score assessed using Profile of Mood State, MENQOL, Chalder Fatigue Scale, Pittsburgh Sleep Quality Index, Female Sexual Function Index and the Brief Pain Inventory questionnaires, respectively. The secondary outcome of the study includes full blood analysis, urine analysis, female reproductive hormone profiling, inflammatory and oxidative stress biomarkers analysis.Ethics and disseminationThe research protocol of the study was reviewed and approved by the Research Ethics Committee of Universiti Kebangsaan Malaysia (UKM/PPI/111/8/JEP-2021-898). The findings will be disseminated to participants, healthcare professionals and researchers via conference presentations and peer-reviewed publications.Trial registration numberACTRN12622001341718.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects ofEurycoma longifolia Jackstandardised water extract (Physta) on well-being of perimenopausal and postmenopausal women: protocol for a randomised, double-blinded, placebo-controlled, parallel group study

Muniandy,

Yahya,

Shahar

et al. 2023

BMJ Open

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Effects of incorporation of Eurycoma longifolia Jack root extract on properties of heat cured acrylic resin

Faisal,

Hummudi,

Yassen

et al. 2023

J Int Oral Health

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Aim: Herbal treatment has recently been validated as a safe and effective alternative to antimicrobial drugs due to its safety and efficiency. Eurycoma longifolia root jack root extract (E.L.) has been documented for its antibacterial and antifungal properties. Acrylic resin is used to produce dentures. However, due to its porous nature, it is a good site for Candida albicans to adhere and cause infection. The aim of the presented study was to evaluate the effects of adding E.L. root extract to acrylic resin on the properties of heat polymerized denture material. Materials and Methods: Sixty circular-shaped (30 mm × 2 mm) specimens were prepared from heat-polymerized acrylic resin in total. Then they were divided into one control group and two experimental groups, which were prepared by adding 0.5 gm of E.L. root extract to 10 mL monomer. Polymer powder was added to the monomer. The conventional water bath method was used for mixing, packing, and processing. Specimens were polished and finished after processing, and then maintained for 48 h in distilled water. Shore D, profilometer tester and color recognition sensor were employed to measure the surface hardness, roughness and color changes. Statistical analysis was conducted via independent sample t test. Results: The results indicated no significant change in roughness values concerning the study groups. Hardness results showed a higher mean value for the experimental group in compared to the control. However, the independent sample t test showed no significant change between the study groups. In color change test, no statistically significant change between experimental and control regarding red and green colors mean values whereas blue color mean values showed significant alteration and color change tests. Conclusion: The study concluded that E. longifolia root extract showed better surface hardness and no effect on color alteration and surface roughness after incorporation to heat cure acrylic resin, which means it can be used as a natural safe antimicrobial agent incorporated into the resin.

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A Systematic Review on Antimicrobial and Antiparasitic Activity of Eurycoma longifolia Jack (Tongkat Ali)

Cited by 2 publications

References 27 publications

Effects ofEurycoma longifolia Jackstandardised water extract (Physta) on well-being of perimenopausal and postmenopausal women: protocol for a randomised, double-blinded, placebo-controlled, parallel group study

Effects ofEurycoma longifolia Jackstandardised water extract (Physta) on well-being of perimenopausal and postmenopausal women: protocol for a randomised, double-blinded, placebo-controlled, parallel group study

Effects of incorporation of Eurycoma longifolia Jack root extract on properties of heat cured acrylic resin

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