A systematic review on black pepper <i>(Piper nigrum</i> L.): from folk uses to pharmacological applications

Takooree, Heerasing; Aumeeruddy, Muhammad Zakariyyah; Rengasamy, Kannan R.R.; Venugopala, Katharigatta N.; Jeewon, Rajesh; Zengin, Gökhan; Mahomoodally, Mohamad Fawzi

doi:10.1080/10408398.2019.1565489

Cited by 247 publications

(169 citation statements)

References 121 publications

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“…Its fruits are popularly used as a hot and pungent spice for flavoring food. Its fruits are usually dried and used as spices and seasonings [ 158 , 159 ]. Black pepper is also used to produce pepper oil and oleoresin, for the production of foods and also for perfumery [ 156 , 157 , 160 ].…”

Section: Bioactive Compounds From Eos Of Spice Plantsmentioning

confidence: 99%

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

et al. 2020

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Spice plants have a great influence on world history. For centuries, different civilizations have used them to condiment the foods of kings and nobles and applied them as embalming preservatives, perfumes, cosmetics, and medicines in different regions of the world. In general, these plants have formed the basis of traditional medicine and some of their derived substances have been utilized to treat different human diseases. Essential oils (EOs) obtained from these plants have been also used as therapeutic agents and have shown supportive uses in remedial practices. The discovery and development of bioactive compounds from these natural products, based on their traditional uses, play an important role in developing the scientific evidence of their potential pharmaceutical, cosmetic, and food applications. In the present review, using recent studies, we exhibit a general overview of the main aspects related to the importance of spice plants widely used in traditional medicine: Cinnamomum zeylanicum (true cinnamon), Mentha piperita (peppermint), Ocimum basilicum (basil), Origanum vulgare (oregano), Piper nigrum (black pepper), Rosmarinus officinalis (rosemary), and Thymus vulgaris (thyme); and we discuss new findings of the bioactive compounds obtained from their EOs, their potential applications, as well as their molecular mechanisms of action, focusing on their antioxidant activity. We also exhibit the main in vitro methods applied to determine the antioxidant activities of these natural products.

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Section: Bioactive Compounds From Eos Of Spice Plantsmentioning

confidence: 99%

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

et al. 2020

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“…Over the last twenty years, numerous studies have shown that many natural products display chemoprotective properties against different types of cancers [1,2]. In this context, piperine (a trans-trans isomer of 1-piperoyl piperidine) (Figure 1), the pungent amide present in Piper spices, such as the widely used black pepper (Piper nigrum L.,) is known to present a broad spectrum of biological activities, including its anti-cancer effect [3][4][5]. Regarding the multidrug resistance (MDR) phenotype, a serious obstacle for the treatment of cancer patients [6], previous studies have demonstrated that piperine inhibits the activity of the main ABC transporters related to MDR phenotype [7,8].…”

Section: Introductionmentioning

confidence: 99%

Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

et al. 2020

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Background: Piperine, an amide extracted from the Piper spices, exhibits strong anti-tumor properties. However, its effect on the epithelial–mesenchymal transition (EMT) process has never been investigated. Herein, we evaluate the toxic effect of piperine on lung adenocarcinoma (A549), breast adenocarcinoma (MDA-MB-231) and hepatocellular carcinoma (HepG2) cell lines, as well as its ability to inhibit EMT-related events induced by TGF-β1 treatment. Methods: The cell viability was investigated by MTT assay. Protein expression was evaluated by Western blot. Gene expression was monitored by real-time PCR. Zymography assay was employed to detect metalloproteinase (MMP) activity in conditioned media. Cell motility was assessed by the wound-healing and phagokinetic gold sol assays. Results: The results revealed that piperine was cytotoxic in concentrations over 100 µM, showing IC50 values for HepG2, MDA-MB-231 and A549 cell lines of 214, 238 and 198 µM, respectively. In order to investigate whether piperine would reverse the TGF-β1 induced-EMT, the A549 cell line was pretreated with sublethal concentrations of the natural amide followed by the addition of TGF-β1. Besides disrupting EMT-related events, piperine also inhibited both ERK 1/2 and SMAD 2 phosphorylation. Conclusions: These results suggest that piperine might be further used in therapeutic strategies for metastatic cancer and EMT-related disorders.

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“…Black pepper also has anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects. The major bioactive compound identified in black pepper is piperine although other compounds are also present including piperic acid, piperlonguminine, pellitorine, piperolein B, piperamide, piperettine, and (-)-kusunokinin, which also showed biological potency (Takooree et al 2019).…”

Section: Third International Symposium On Phytochemicals In Medicine mentioning

confidence: 99%

Third International Symposium on Phytochemicals in Medicine and Food

Bai

Xiao

2019

Critical Reviews in Food Science and Nutrition

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A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications

Cited by 247 publications

References 121 publications

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

Third International Symposium on Phytochemicals in Medicine and Food

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